An in vitro study on 5-HT6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics

Toxicology in Vitro

Volumn 21, Issue 7, 2007, Pages 1276-1286

  Boess, F ^a   Durr, E ^a   Schaub, N ^a   Haiker, M ^a   Albertini, S ^a   Suter, L ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Hepatotoxicity in vitro; Toxicogenomics

Indexed keywords

CYTOCHROME P450; R 0074; R 7199; SEROTONIN 6 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; FATTY ACID OXIDATION; GENE EXPRESSION; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHOLESTEROL; CYTOCHROME P-450 CYP2B1; ENZYME INDUCTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; HOMEOSTASIS; LIPID METABOLISM; LIVER; MALE; OXIDATION-REDUCTION; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; TOXICOGENETICS;

ANIMALIA; RATTUS;

EID: 35648942198     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.03.014     Document Type: Article

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