Temporal gene expression analysis of monolayer cultured rat hepatocytes

Chemical Research in Toxicology

Volumn 14, Issue 9, 2001, Pages 1218-1231

  Baker, T K ^a   Carfagna, M A ^a   Gao, H ^a   Dow, E R ^a   Li, Q ^a   Searfoss, G H ^a   Ryan, T P ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GLUTATHIONE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CELL HYBRIDIZATION; CELL ISOLATION; CELL SHAPE; CLUSTER ANALYSIS; CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE INDUCTION; GLUCONEOGENESIS; GLUCURONIDATION; GLUTATHIONE METABOLISM; GLYCOLYSIS; LIVER CELL; LIVER TOXICITY; MALE; MONOLAYER CULTURE; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SULFATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL CULTURE TECHNIQUES; CELL CYCLE; GENE EXPRESSION REGULATION; HEPATOCYTES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED F344; TIME FACTORS; TOXICITY TESTS; UP-REGULATION;

EID: 0034813961     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx015518a     Document Type: Article

References (50)

1. Structural organization of the liver
2. The liver and gallbladder
3. Transcriptional control in the production of liver-specific mRNAs
4. High-yield preparation of isolated rat liver parenchymal cells
5. 2+ on enzymatic dispersion of isolated, perfused liver
6. Preparation of isolated rat liver cells
7. Covalent binding of trichloroethylene to proteins in human and rat hepatocytes
8. The metabolism of drugs in isolated rat hepatocytes: A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions
9. Application of isolated hepatocytes to studies of drug metabolism in large food animals
10. Use of human hepatocyte cultures for drug metabolism studies
11. Cultured hepatocytes for studies of peroxisome proliferation: Methods and applications
12. Immortalized hepatocytes as in vitro model systems for toxicity testing: The comparative toxicity of menadione in immortalized cells, primary cultures of hepatocytes find HTC hepatoma cells
13. Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: A preliminary structure-toxicity relationship study
14. Ethionine toxicity in vitro: The correlation of data from rat hepatocyte suspensions and monolayers with in vivo observations
15. Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes
16. The measurement of lipid peroxidation in isolated hepatocytes
17. Tumor necrosis factor α (TNFα) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: A mediator of the hepatocarcinogenicity of peroxisome proliferators
18. Fas-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model
19. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
20. Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes
21. Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures
22. Retention of xenobiotic-inducible cytochrome P450 gene expression in hepatocytes
23. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes
24. Exploring the new world of the genome with DNA microarrays
25. Experimental annotation of the human genome using microarray technology
26. High-density synthetic oligonucleotide arrays
27. Mouse liver cell culture I. Hepatocyte Isolation
28. Self-organized formation of topologically correct feature maps
29. The self-organizing map
30. Self-organizing feature maps: Kohonen maps
31. Exploration of very large databases by self-organizing maps
32. Analysis of neighborhood interaction in Kohonen neural networks
33. Analysis of the convergence properties of topology preserving neural networks
34. Monitoring cellular responses to Listeria monocytogenes with oligonucleotide arrays
35. Morphological and functional studies of mouse hepatocytes in primary culture
36. Modulation of functional activities in cultured hepatocytes
37. Fetal phenotypic expression by adult rat hepatocytes on collagen gel/nylon meshes
38. Comparative induction of cytochrome P4504A in rat hepatocyte culture by the peroxisome proliferators, bifonazole and clofibrate
39. Glucuronidation of thyroxine in primary monolayer cultures of rat hepatocytes: In vitro induction of UDP-glucuronosyltransferases by methylcholanthrene, clofibrate, and dexamethasone alone and in combination
40. Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice
41. The effects of hepatic regeneration on the expression of the glutathione S-transferases
42. Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes
43. Regulation of glutathione synthesis
44. The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology
45. Stretching is good for a cell
46. Control of cell behavior by signaling through Eph receptors and ephrins
47. 1 switch gene 2 (GOS2) in cultured human blood mononuclear cells
48. Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development, and regeneration
49. WAF1/Cipl/Sdil gene expression in hepatic regeneration