메뉴 건너뛰기




Volumn 66, Issue 3, 2009, Pages 407-414

Simvastatin therapy prevents brain trauma-induced increases in β-amyloid peptide levels

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; SIMVASTATIN;

EID: 70350061584     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21731     Document Type: Article
Times cited : (78)

References (63)
  • 1
    • 0142040778 scopus 로고    scopus 로고
    • The Epidemiology of Traumatic Brain Injury: A Review
    • Bruns J, Hauser WA. The epidemiology of traumatic brain injury: a review. Epilepsia 2003;44(suppl 10):2-10. (Pubitemid 37280386)
    • (2003) Epilepsia , vol.44 , Issue.SUPPL. 10 , pp. 2-10
    • Bruns Jr., J.1    Hauser, W.A.2
  • 3
    • 1542616510 scopus 로고    scopus 로고
    • Traumatic brain injury as a risk factor for Alzheimer's disease [9]
    • Jellinger KA. Traumatic brain injury as a risk factor for Alzheimer's disease. J Neurol Neurosurg Psychiatr 2004;75: 511-512. (Pubitemid 38338800)
    • (2004) Journal of Neurology, Neurosurgery and Psychiatry , vol.75 , Issue.3 , pp. 511-512
    • Jellinger, K.A.1
  • 4
    • 0023905906 scopus 로고
    • Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
    • Katzman R, Terry R, DeTeresa R, et al. Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988;23:138-144. (Pubitemid 18081451)
    • (1988) Annals of Neurology , vol.23 , Issue.2 , pp. 138-144
    • Katzman, R.1    Terry, R.2    Deteresa, R.3    Brown, T.4    Davies, P.5    Fuld, P.6    Renbing, X.7    Peck, A.8
  • 5
    • 0027278450 scopus 로고
    • Molecular pathology of head trauma: Altered β APP metabolism and the aetiology of Alzheimer's disease
    • Kogure K, Hossmann K-A, Siesjo BK, eds. New York: Elsevier Science Publishers BV
    • Gentleman SM, Graham DI, Roberts GW. Molecular pathology of head trauma: altered β APP metabolism and the aetiology of Alzheimer's disease. In: Kogure K, Hossmann K-A, Siesjo BK, eds. Progress in brain research. Vol 96. New York: Elsevier Science Publishers BV, 1993:237-246.
    • (1993) Progress in Brain Research , vol.96 , pp. 237-246
    • Gentleman, S.M.1    Graham, D.I.2    Roberts, G.W.3
  • 7
    • 34247137869 scopus 로고    scopus 로고
    • Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
    • DeKosky ST, Abrahamson EE, Ciallella JR, et al. Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans. Arch Neurol 2007;64: 541-544.
    • (2007) Arch Neurol , vol.64 , pp. 541-544
    • Dekosky, S.T.1    Abrahamson, E.E.2    Ciallella, J.R.3
  • 8
    • 0025840201 scopus 로고
    • βA4 amyloid protein deposition in brain after head trauma
    • Roberts GW, Gentleman SM, Lynch A, Graham DI. βA4 amyloid protein deposition in brain after head trauma. Lancet 1991;338:1422-1423.
    • (1991) Lancet , vol.338 , pp. 1422-1423
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3    Graham, D.I.4
  • 10
    • 0030612292 scopus 로고    scopus 로고
    • A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury
    • Gentleman SM, Greenberg BD, Savage MJ, et al. A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury. NeuroReport 1997;8: 1519-1522.
    • (1997) NeuroReport , vol.8 , pp. 1519-1522
    • Gentleman, S.M.1    Greenberg, B.D.2    Savage, M.J.3
  • 13
    • 0030250615 scopus 로고    scopus 로고
    • Beta-Amyloid converts an acute phase injury response to chronic injury responses
    • Cotman CW, Tenner AJ, Cummings BJ. beta-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol Aging 1996;17:723-731.
    • (1996) Neurobiol Aging , vol.17 , pp. 723-731
    • Cotman, C.W.1    Tenner, A.J.2    Cummings, B.J.3
  • 14
    • 0023521261 scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors in the treatment of hypercholesterolemia
    • DOI 10.1001/jama.258.24.3532
    • Hoeg JM, Brewer HBJ. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of hypercholesterolemia. JAMA 1987;258:3532-3536. (Pubitemid 18007514)
    • (1987) Journal of the American Medical Association , vol.258 , Issue.24 , pp. 3532-3536
    • Hoeg, J.M.1    Brewer Jr., H.B.2
  • 15
    • 28844474981 scopus 로고    scopus 로고
    • Statin therapy in the treatment of Alzheimer's disease: What is the rationale?
    • DeKosky ST. Statin therapy in the treatment of Alzheimer's disease: what is the rationale? Am J Med 2005;118:48-53.
    • (2005) Am J Med , vol.118 , pp. 48-53
    • Dekosky, S.T.1
  • 20
    • 0942290538 scopus 로고    scopus 로고
    • Atorvastatin Reduces Neurological Deficit and Increases Synaptogenesis, Angiogenesis, and Neuronal Survival in Rats Subjected to Traumatic Brain Injury
    • Lu D, Goussev A, Chen J, et al. Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma 2004;21:21-32. (Pubitemid 38141799)
    • (2004) Journal of Neurotrauma , vol.21 , Issue.1 , pp. 21-32
    • Lu, D.1    Goussev, A.2    Chen, J.3    Pannu, P.4    Li, Y.5    Mahmood, A.6    Chopp, M.7
  • 21
    • 0026062640 scopus 로고
    • A controlled cortical impact model of traumatic brain injury in the rat
    • Dixon CE, Clifton GL, Lighthall LW, et al. A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Meth 1991;39:253-262.
    • (1991) J Neurosci Meth , vol.39 , pp. 253-262
    • Dixon, C.E.1    Clifton, G.L.2    Lighthall, L.W.3
  • 22
    • 0029788661 scopus 로고    scopus 로고
    • Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence
    • Reaume AG, Howland DS, Trusko SP, et al. Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence. J Biol Chem 1996;271:23380-23388.
    • (1996) J Biol Chem , vol.271 , pp. 23380-23388
    • Reaume, A.G.1    Howland, D.S.2    Trusko, S.P.3
  • 23
    • 0036228106 scopus 로고    scopus 로고
    • FAD mutant PS-1 gene-targeted mice: Increased a beta 42 and a beta deposition without APP overproduction
    • Flood DG, Reaume AG, Dorfman KS, et al. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiol Aging 2002;23: 335-348.
    • (2002) Neurobiol Aging , vol.23 , pp. 335-348
    • Flood, D.G.1    Reaume, A.G.2    Dorfman, K.S.3
  • 24
    • 30444437033 scopus 로고    scopus 로고
    • Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: Implications for clinical outcome
    • Abrahamson EE, Ikonomovic MD, Ciallella JR, et al. Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome. Exp Neurol 2006;197:437-450.
    • (2006) Exp Neurol , vol.197 , pp. 437-450
    • Abrahamson, E.E.1    Ikonomovic, M.D.2    Ciallella, J.R.3
  • 25
    • 48249111737 scopus 로고    scopus 로고
    • Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury
    • Tehranian R, Rose M, Vagni V, et al. Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury. J Neurotrauma 2008;25:755-767.
    • (2008) J Neurotrauma , vol.25 , pp. 755-767
    • Tehranian, R.1    Rose, M.2    Vagni, V.3
  • 26
    • 58149269462 scopus 로고    scopus 로고
    • The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo
    • Xie Z, Culley D, Dong Y, et al. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol 2008;64:618-627.
    • (2008) Ann Neurol , vol.64 , pp. 618-627
    • Xie, Z.1    Culley, D.2    Dong, Y.3
  • 27
    • 0032926263 scopus 로고    scopus 로고
    • Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: Assessment of histopathologic and functional outcome
    • Whalen MJ, Carlos TM, Dixon CE, et al. Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome. J Neurotrauma 1999;16:299-309.
    • (1999) J Neurotrauma , vol.16 , pp. 299-309
    • Whalen, M.J.1    Carlos, T.M.2    Dixon, C.E.3
  • 28
    • 34248190279 scopus 로고    scopus 로고
    • A beta oligomers - A decade of discovery
    • Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. J Neurochem 2007;101:1172-1184.
    • (2007) J Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 30
    • 33846048569 scopus 로고    scopus 로고
    • Simvastatin enhances learning and memory independent of amyloid load in mice
    • DOI 10.1002/ana.21053
    • Li L, Cao D, Kim H, et al. Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 2006;60:729-739. (Pubitemid 46061359)
    • (2006) Annals of Neurology , vol.60 , Issue.6 , pp. 729-739
    • Li, L.1    Cao, D.2    Kim, H.3    Lester, R.4    Fukuchi, K.-I.5
  • 31
    • 0033519601 scopus 로고    scopus 로고
    • The role of cholesterol in the biosynthesis of beta-amyloid
    • Frears ER, Stephens DJ, Walters CE, et al. The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 1999;10: 1699-1705.
    • (1999) Neuroreport , vol.10 , pp. 1699-1705
    • Frears, E.R.1    Stephens, D.J.2    Walters, C.E.3
  • 35
    • 0031278270 scopus 로고    scopus 로고
    • Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
    • Bales K, Verina T, Dodel R, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet 1997;17:263-264.
    • (1997) Nat Genet , vol.17 , pp. 263-264
    • Bales, K.1    Verina, T.2    Dodel, R.3
  • 36
    • 0026452028 scopus 로고
    • Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: Modulation by interleukin-1
    • Forloni G, Demicheli F, Giorgi S, et al. Expression of amyloid precursor protein mRNAs in endothelial, neuronal, and glial cells: modulation by interleukin-1. Brain Res Mol Brain Res 1992;16:128-134.
    • (1992) Brain Res Mol Brain Res , vol.16 , pp. 128-134
    • Forloni, G.1    Demicheli, F.2    Giorgi, S.3
  • 37
    • 0026448114 scopus 로고
    • Cholinergic agonists and interleukin-1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor
    • Buxbaum JD, Oishi M, Chen HI, et al. Cholinergic agonists and interleukin-1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc Natl Acad Sci U S A 1992;89:10075-10078.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10075-10078
    • Buxbaum, J.D.1    Oishi, M.2    Chen, H.I.3
  • 38
    • 0028167986 scopus 로고
    • Microglial interleukin-1alpha expression in human head injury: Correlations with neuronal and neuritic beta-amyloid precursor protein expression
    • DOI 10.1016/0304-3940(94)90066-3
    • Griffin WS, Sheng JG, Gentleman SM, et al. Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression. Neurosci Lett 1994;176:133-136. (Pubitemid 2119762)
    • (1994) Neuroscience Letters , vol.176 , Issue.2 , pp. 133-136
    • Griffin, W.S.T.1    Sheng Jin, G.2    Gentleman, S.M.3    Graham, D.I.4    Mrak, R.E.5    Roberts, G.W.6
  • 39
    • 70049102020 scopus 로고    scopus 로고
    • Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells
    • Epub ahead of print. PMID:18339452, doi:10.1016/j.neurobiolaging. 2008.01.011
    • Parvathy S, Rajadas J, Ryan H, et al. Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells. Neurobiol Aging. Epub ahead of print. PMID:18339452, doi:10.1016/j. neurobiolaging. 2008.01.011).
    • Neurobiol Aging
    • Parvathy, S.1    Rajadas, J.2    Ryan, H.3
  • 40
    • 33845903037 scopus 로고    scopus 로고
    • 1-42 in the rat hippocampus in vivo
    • DOI 10.1016/j.neuropharm.2006.07.031, PII S0028390806002516
    • Clarke RM, O'Connell F, Lyons A, Lynch MA. The HMGCoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1 - 42 in the rat hippocampus in vivo. Neuropharmacology 2007;52:136-145. (Pubitemid 46026837)
    • (2007) Neuropharmacology , vol.52 , Issue.1 , pp. 136-145
    • Clarke, R.M.1    O'Connell, F.2    Lyons, A.3    Lynch, M.A.4
  • 41
    • 1842610852 scopus 로고    scopus 로고
    • Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5
    • DOI 10.1523/JNEUROSCI.1633-03.2004
    • Wang Q, Walsh DM, Rowan MJ, et al. Block of long-term potentiation by naturally secreted and synthetic amyloid betapeptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci 2004;24:3370-3378. (Pubitemid 38451902)
    • (2004) Journal of Neuroscience , vol.24 , Issue.13 , pp. 3370-3378
    • Wang, Q.1    Walsh, D.M.2    Rowan, M.J.3    Selkoe, D.J.4    Anwyl, R.5
  • 42
    • 44949138575 scopus 로고    scopus 로고
    • Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury
    • Nadler Y, Alexandrovich A, Grigoriadis N, et al. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury. Glia 2008;56:552-567.
    • (2008) Glia , vol.56 , pp. 552-567
    • Nadler, Y.1    Alexandrovich, A.2    Grigoriadis, N.3
  • 44
    • 21444445440 scopus 로고    scopus 로고
    • Statins cause intracellular accumulation of amyloid precursor protein, β-secretase-cleaved fragments, and amyloid β-peptide via an isoprenoid-dependent mechanism
    • DOI 10.1074/jbc.M413895200
    • Cole SL, Grudzien A, Manhart IO, et al. Statins cause intracellular accumulation of amyloid precursor protein, betasecretase- cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism. J Biol Chem 2005;280: 18755-18770. (Pubitemid 41379577)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 18755-18770
    • Cole, S.L.1    Grudzien, A.2    Manhart, I.O.3    Kelly, B.L.4    Oakley, H.5    Vassar, R.6
  • 45
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesne S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440:352-357.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3
  • 46
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson MP. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 1997; 77:1081-1132.
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 47
    • 32044440770 scopus 로고    scopus 로고
    • Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury
    • Qu C, Lu D, Goussev A, et al. Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury. J Neurosurg 2005;103:695-701. (Pubitemid 43193877)
    • (2005) Journal of Neurosurgery , vol.103 , Issue.4 , pp. 695-701
    • Qu, C.1    Lu, D.2    Goussev, A.3    Schallert, T.4    Mahmood, A.5    Chopp, M.6
  • 48
    • 59649123631 scopus 로고    scopus 로고
    • Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin
    • Mahmood A, Goussev A, Lu D, et al. Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin. J Neurotrauma 2008;25:1441-1447.
    • (2008) J Neurotrauma , vol.25 , pp. 1441-1447
    • Mahmood, A.1    Goussev, A.2    Lu, D.3
  • 49
    • 0346749450 scopus 로고    scopus 로고
    • 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity
    • Zacco A, Togo J, Spence K, et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 2003;23:11104-11111. (Pubitemid 37548945)
    • (2003) Journal of Neuroscience , vol.23 , Issue.35 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3    Ellis, A.4    Lloyd, D.5    Furlong, S.6    Piser, T.7
  • 51
    • 33747821467 scopus 로고    scopus 로고
    • Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury
    • DOI 10.1097/01.jnen.0000225906.82428.69, PII 0000507220060700000003
    • He X, Jenner AM, Ong WY, et al. Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. J Neuropathol Exp Neurol 2006;65:652-663. (Pubitemid 44297256)
    • (2006) Journal of Neuropathology and Experimental Neurology , vol.65 , Issue.7 , pp. 652-663
    • He, X.1    Jenner, A.M.2    Ong, W.-Y.3    Farooqui, A.A.4    Patel, S.C.5
  • 52
    • 3042656548 scopus 로고    scopus 로고
    • Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats
    • Seyfried D, Han Y, Lu D, et al. Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats. J Neurosurg 2004;101: 104-107. (Pubitemid 38808468)
    • (2004) Journal of Neurosurgery , vol.101 , Issue.1 , pp. 104-107
    • Seyfried, D.1    Han, Y.2    Lu, D.3    Chen, J.4    Bydon, A.5    Chopp, M.6
  • 53
    • 7244250060 scopus 로고    scopus 로고
    • Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury
    • Lu D, Mahmood A, Goussev A, et al. Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury. J Neurosurg 2004;101: 813-821. (Pubitemid 39430975)
    • (2004) Journal of Neurosurgery , vol.101 , Issue.5 , pp. 813-821
    • Lu, D.1    Mahmood, A.2    Goussev, A.3    Schallert, T.4    Qu, C.5    Zheng, G.Z.6    Li, Y.7    Lu, M.8    Chopp, M.9
  • 54
    • 0031814850 scopus 로고    scopus 로고
    • The molecular and cellular sequelae of experimental traumatic brain injury: Pathogenetic mechanisms
    • The Dorothy Russell Memorial Lecture
    • McIntosh TK, Saatman KE, Raghupathi R, et al. The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathol Appl Neurobiol 1998;24:251-267.
    • (1998) Neuropathol Appl Neurobiol , vol.24 , pp. 251-267
    • McIntosh, T.K.1    Saatman, K.E.2    Raghupathi, R.3
  • 55
    • 33846450284 scopus 로고    scopus 로고
    • Prevention of stroke and dementia by statin therapy: Experimental and clinical evidence of their pleiotropic effects
    • DOI 10.1016/j.pharmthera.2006.09.003, PII S0163725806001719
    • Miida T, Takahashi A, Ikeuchi T. Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects. Pharmacol Ther 2007;113:378-393. (Pubitemid 46149052)
    • (2007) Pharmacology and Therapeutics , vol.113 , Issue.2 , pp. 378-393
    • Miida, T.1    Takahashi, A.2    Ikeuchi, T.3
  • 56
    • 12144261198 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses
    • DOI 10.1523/JNEUROSCI.2544-04.2005
    • Cordle A, Landreth G. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses. J Neurosci 2005;25:299-307. (Pubitemid 40105600)
    • (2005) Journal of Neuroscience , vol.25 , Issue.2 , pp. 299-307
    • Cordle, A.1    Landreth, G.2
  • 57
    • 55949135811 scopus 로고    scopus 로고
    • Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury
    • Wu H, Lu D, Jiang H, et al. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg 2008;109:691-698.
    • (2008) J Neurosurg , vol.109 , pp. 691-698
    • Wu, H.1    Lu, D.2    Jiang, H.3
  • 58
    • 17044380213 scopus 로고    scopus 로고
    • Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke
    • DOI 10.1016/j.brainres.2005.01.105
    • Shabanzadeh AP, Shuaib A, Wang CX. Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke. Brain Res 2005;1042:1-5. (Pubitemid 40501309)
    • (2005) Brain Research , vol.1042 , Issue.1 , pp. 1-5
    • Shabanzadeh, A.P.1    Shuaib, A.2    Wang, C.X.3
  • 59
    • 34250630954 scopus 로고    scopus 로고
    • Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    • DOI 10.1016/j.expneurol.2007.03.031, PII S0014488607001379
    • Wang H, Lynch JR, Song P, et al. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol 2007;206:59-69. (Pubitemid 46935123)
    • (2007) Experimental Neurology , vol.206 , Issue.1 , pp. 59-69
    • Wang, H.1    Lynch, J.R.2    Song, P.3    Yang, H.-J.4    Yates, R.B.5    Mace, B.6    Warner, D.S.7    Guyton, J.R.8    Laskowitz, D.T.9
  • 60
    • 0030926446 scopus 로고    scopus 로고
    • The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. a new principle in peptide function and the induction of neuropathology
    • Cotman CW. The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology. Ann NY Acad Sci 1997;814:1-16.
    • (1997) Ann NY Acad Sci , vol.814 , pp. 1-16
    • Cotman, C.W.1
  • 63
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar G, Li S, Mehta T, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008;14:837-842.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.1    Li, S.2    Mehta, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.