β-Amyloid converts an acute phase injury response to chronic injury responses

Neurobiology of Aging

Volumn 17, Issue 5, 1996, Pages 723-731

  Cotman, Carl W ^a   Tenner, Andrea J ^b   Cummings, Brian J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Acute phase injury response; Chronic injury response; Inflammatory response; Plasticity; Senile plaques; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN;

ACUTE PHASE RESPONSE; ALZHEIMER DISEASE; COMPLEMENT SYSTEM; HUMAN; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

EID: 0030250615     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(96)00117-0     Document Type: Article

References (96)

1. 1. Afagh, A.; Cummings, B. J.; Cribbs, D. H.; Cotman, C. W.; Tenner, A. J. Localization and cell association of C1q in Alzheimer's disease brain. Exp. Neurol. 138:22-32; 1996.
2. 2. Andersen, K.; Launer, L. J.; Ott, A.; Hoes, A. W.; Breteler, M. M.; Hofman, A. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study, Neurology 45:1441-1445; 1995.
3. 3. Araujo, D. M.; Cotman, C. W. Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lymphokines and trophic factors. J. Neurosci. 12:1668-1678; 1992.
4. 4. Araujo, D. M.; Cotman, C. W. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 569:141-145; 1992.
5. 5. Araujo, D. M.; Cotman, C. W. Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: Potential involvement of glial-derived factors. Brain Res. 600:49-55; 1993.
6. 6. Barnum, S. R, Biosynthesis and regulation of complement by cells of the central nervous system. In: Cruse, J. M.; Lewis, R. E., Jr., eds. Complement today. New York: Karger; 1993:
7. 7. Behl, C.; Davis, J. B.; Lesley, R.; Schubert, D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827; 1994.
8. 8. Bobak, D. A.; Frank, M. M.; Tenner, A. J. C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. Eur. J. Immunol. 18:2001-2007; 1988.
9. 9. Bobak, D. A.; Gaither, T. A.; Frank, M. M.; Tenner, A. J. Modulation of FcR function by complement: Subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J. Immunol. 138:1150-1156; 1987.
10. 10. Braak, H.; Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 82:239-259; 1991.
11. 11. Breitner, J. C.; Gau, B. A.; Welsh, K. A.; Plassman, B. L.; McDonald, W. M.; Helms, M. J.; Anthony, J. C. Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study. Neurology 44:227-232; 1994.
12. 12. Breitner, J. C. S.; Welsh, K. A.; Helms, M. J.; Gaskell, P.C.; Gau, B. A.; Roses, A. D.; Pericak-Vance. M. A.; Saunders, A. M. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histmaine H2 blocking drugs. Neurobiol. Aging 4:523-530; 1995.
13. 13. Colton, C. A.; Gilbert, D. L. Microglia, an in vivo source of reactive oxygen species in the brain. Adv. Neurol. 59:321-326; 1993.
14. 14. Cotman, C. W.; Cummings, B. J.; Pike, C. J. Molecular cascades in adaptive vs. pathologic plasticity. In; Gorio. A., eds. Neuroregeneration. New York: Raven Press; 1993:
15. 15. Cotman, C. W.; Gómez-Pinilla, F. Basic fibroblast growth factor in the mature brain and its possible role in Alzheimer's disease. Ann. NY Acad. Sci. 638:221-231; 1991.
16. 16. Cotman, C. W.; Gómez-Pinilla, F.; Kahle, J. S. Neural plasticity and regeneration. In: Siegel, G. J.; Agranoff, B. W.; Albers, R. W.; Molinoff. P. B., eds. Basic neurochemistry: Molecular, cellular, and medical aspects, 5th ed. New York: Raven Press, Ltd.; 1994:608-628.
17. 17. Cotman, C. W.; Nieto-Sampedro, M. Cell biology of synaptic plasticity. Science 225:1287-1294; 1984.
18. 18. Cummings, B.; Pike, C.; Shankle, R.; Cotman, C. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol. Aging (in press).
19. 19. Cummings, B. J.; Su, J. H.; Cotman, C. W. Neuritic involvement within the bFGF immunopositive plaques of Alzheimer's disease. Exp. Neurol. 124:315-325; 1993.
20. 20. Cummings, B. J.; Afagh, A.; Weinstein, S. L.; Cotman, C. W. Semi-quantitative differential association of reactive microglia with plaque subtype, (submitted).
21. 21. Cummings, B. J.; Su, J. H.; Cotman, C. W.; White, R.; Russell, M. J. Beta-amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease. Neurobiol. Aging 14:547-560; 1993.
22. 22. Cummings, B. J.; Su, J. H.; Geddes, J. W.; Van Nostrand, W. E.; Wagner, S. L.; Cunningham, D. D.; Cotman, C. W. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neuntes in Alzheimer's disease. Neuroscience 48:763-777; 1992.
23. 23. Dickson, D. W.; Farlo, J.; Davies, P.; Crystal, H.; Fuld, P.; Yen, S. H. Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am. J. Pathol. 132:86-101; 1988.
24. 24. Dickson, D. W.; Lee, S. C.; Mattiace, L. A.; Yen, S. H.; Brosnan, C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75-83; 1993.
25. 25. Duffy, P. E.; Rapport, M.; Graf, L. Glial fibrillary acidic protein and Alzheimer-type senile dementia. Neurology 30:778-782; 1990.
26. 26. Eddleston, M.; Mucke, L. Molecular profile of reactive astrocytes -Implications for their role in neurologic disease. Neuroscience 54:15-36; 1993.
27. 27. Eikelenboom, P.; Hack, C. E.; Rozemuller, J. M.; Stam, F. C. Complement activation in amyloid plaques in Alzheimer s dementia. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 56:259-262; 1989.
28. 28. Eikelenboom, P.; Stam, F. C. Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study. Acta Neuropathol. (Berl.) 57:239-242; 1982.
29. 29. Frackowiak, J.; Wisniewski, H. M.; Wegiel, J.; Merz, G. S.; Iqbal, K.; Wang, K. C. Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol. (Berl.) 84:225-233; 1992.
30. 30. Frank, M. M.; Fries, L. F. The role of complement in inflammation and phagocytosis. Immunol. Today 12:322-326; 1991.
31. 31. Frautschy, S. A.; Cole, G. M.; Baird, A. Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. Am. J. Pathol. 140:1389-1399; 1992.
32. 32. Frölich, L.; Kornhuber, J.; Ihl, R.; Fritze, J.; Maurer, K.; Riederer, P. Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF/serum ratios of albumin and IgG. Eur. Arch. Psychiatr. Clin. Neurosci. 240:363-366; 1991.
33. 33. Casque, P.; Chan, P.; Fontaine, M.; Ischenko, A.; Lamacz, M.; Götze, O.; Morgan, B. P. Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. J. Immunol. 155:4882-4889; 1995.
34. 34. Gasque, P.; Fontaine, M.; Morgan, B. P. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J. Immunol. 154:4726-4733; 1995.
35. 35. Geddes, J. W.; Anderson, K. J.; Cotman, C. W. Senile plaques as aberrant sprout-stimulating structures. Exp. Neurol. 94:767-776; 1986.
36. 36. Giulian, D.; Baker, T. J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6:2163-2178; 1986.
37. 37. Gömez-Pinilla, F.; Cummings, B. J.; Cotman, C. W. Induction of basic fibroblast growth factor in Alzheimer's disease pathology. Neuroreport 1:211-214; 1990.
38. 38. Goodman, E. B.; Tenner. A. J. Signal transduction mechanisms of C1q-mediated Superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways. J. Immunol. 148:3920-3928; 1992.
39. 39. Guan, E.; Robinson, S. L.; Goodman, E. B.; Tenner, A. J. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J. Immunol. 152:4005-4016; 1994.
40. 40. Haga, S.; Akai, K.; Ishii, T. Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol. (Berl.) 77:569-575; 1989.
41. 41. Haga, S.; Ikeda, K.; Sato, M; Ishii, T. Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601:88-94; 1993.
42. 42. Hyman, B. T.; Van Hoesen, G. W.; Damasio, A. R.; Barnes, C. L. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation. Science 225:1168-1170; 1984.
43. 43. Ishii, T.; Haga, S. Immuno-electron-microscopic localization of complement in amyloid fibrils of senile plaques. Acta Neuropathol. (Berl.) 63:296-300; 1984.
44. 44. Itagaki, S.; McGeer, P. L.; Akiyama, H.; Zhu, S.; Selkoe, D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24:173-182; 1989.
45. 45. Jenkinson, M. L.; Bliss, M. R.; Brain, A. T.; Scott, D. L. Rheumatoid arthritis and senile dementia of the Alzheimer's type [letter]. Br. J. Rheumatol. 28:86-88; 1989.
46. 46. Jiang, H.; Burdick, D.; Glabe, C. G.; Cotman, C. W.; Tenner, A. J. β-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immunol. 152:5050-5059; 1994.
47. 47. Jiang, H.; Cooper, B.; Robey, F. A.; Gewurz, H. DNA binds and activates complement via residues 14-26 of the human C1q A chain. J. Biol. Chem. 267:25597-25601; 1992.
48. 48. Jiang, H.; Robey, F. A.; Gewurz, H. Localization of sites through which C-reactive protein binds and activates complement to residues 14-26 and 76-92 of the human C1q A chain. J. Exp. Med. 175:1373-1379; 1992.
49. 49. Johnson, S.A.; Lampert-Etchells, M.; Pasinetti, G. M.; Rozovsky, I.; Finch, C. E. Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning. Neurobiol. Aging 13:641-648; 1992.
50. 50. Knauer, M. F.; Soreghan, B.; Burdick, D.; Kosmoski, J.; Glabe, C. G. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein. Proc. Natl. Acad. Sci. USA 89:7437-7441; 1992.
51. 51. Korotzer, A. R.; Pike, C. J.; Cotman, C. W. beta-Amyloid peptides induce degeneration of cultured rat microglia. Brain Res. 624:121-125; 1993.
52. 52. Korotzer, A. R.; Watt, J.; Cribbs, D.; Tenner, A. J.; Burdick, D.; Glabe, C.; Cotman, C. W. Cultured rat microglia express C1q and receptor for C1q: Implications for amyloid effects on microglia. Exp. Neurol. 134:214-221; 1995.
53. 53. Lampert-Etchells, M.; Pasinetti, G. M.; Finch, C. E.; Johnson, S. A. Regional localization of cells containing complement C1q and C4 mRNAs in the frontal cortex during Alzheimers disease. Neurodegeneration 2:111-121; 1993.
54. 54. Lee, S. C.; Liu, W.; Dickson, D. W.; Brosnan, C. F.; Berman, J. W. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J. Immunol. 150: 2659-2667; 1993.
55. 55. Lévi-Strauss, M.; Mallat, M. Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation. J. Immunol. 139:2361-2366; 1987.
56. 56. Lynch, G.; Rose, G.; Gall, C.; Cotman, C. W. The response of the dentate gyrus to partial deafferentation. In: Santini, M., eds. Golgi centennial symposium proceedings. New York: Raven Press; 1975:305-317.
57. 57. Mandybur, T. I.; Chuirazzi, C. C. Astrocytes and the plaques of Azheimer's disease. Neurology 40:635-639; 1990.
58. 2+ homeostasis in Alzheimer's disease. Trends Neurosci. 16:409-414; 1993.
59. 59. Mattson, M. P.; Rydel, R. E. beta-Amyloid precursor protein and Alzheimer's disease: The peptide plot thickens. Neurobiol. Aging 13:617-621; 1992.
60. 60. May, P. C.; Boggs, L. N.; Fuson, K. S. Neurotoxicity of human amylin in rat primary hippocampal cultures: Similarity to Alzheimer's disease amyloid-beta neurotoxicity. J. Neurochem. 61:2330-2333; 1993.
61. 61. McGeer, P. L.; Akiyama, H.; Itagaki, S.; McGeer, E. G. Immune system response in Alzheimer's disease. Can. J. Neurol. Sci. 16:516-527; 1989.
62. 62. McGeer, P. L.; Kawamata, T.; Walker, D. G.; Akiyama, H.; Tooyama, I.; McGeer, E. G. Microglia in degenerative neurological disease. Glia 7:84-92; 1993.
63. 63. McGeer, P. L.; McGeer, E. G. Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol. 143:621-624; 1992.
64. 64. McGeer, P. L.; Rogers, J. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42:447-449; 1992.
65. 65. Meda, L.; Cassatella, M. A.; Szendrei, G.I.; Otvos, L., Jr.; Baron, P.; Villalba, M.; Ferrari, D.; Rossi, F. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374:647-650; 1995.
66. 66. Morgan, T. E.; Nichols, N. R.; Pasinetti, G. M.; Finch, C. E. TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration. Exp. Neurol. 120:291-301; 1993.
67. 67. Mrak, R. E.; Sheng, J. G.; Griffin, W. S. Glial cytokines in Alzheimer's disease: Review and pathogenic implications. Hum. Pathol. 26: 816-823; 1995.
68. 68. Nakajima, K.; Shimojo, M.; Hamanoue, M.; Ishiura, S.; Sugita, H.; Kohsaka, S. Identification of elastase as a secretory protease from cultured rat microglia. J. Neurochem. 58:1401-1408; 1992.
69. 69. Nieto-Sampedro, M.; Cotman, C. W. Growth factor induction and temporal order in CNS repair. In: Cotman, C. W., eds. Synaptic plasticity. New York: Guilford Press; 1985.
70. 70. Perry, V. H.; Andersson, P. B.; Gordon, S. Macrophages and inflammation in the central nervous system. Trends Neurosci. 16:268-273; 1993.
71. 71. Perry, V. H.; Gordon, S. Macrophages and the nervous system. Int. Rev. Cytol. 125:203-244; 1991.
72. 72. Pike, C. J.; Cummings, B. J.; Cotman, C. W. beta-Amyloid induces neuritic dystrophy in vitro: Similarities with Alzheimer pathology. Neuroreport 3:769-772; 1992.
73. 73. Pike, C. J.; Cummings, B. J.; Cotman, C. W. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Exp. Neurol. 132:172-179; 1995.
74. 74. Pike, C. J.; Cummings, B. J.; Monzavi, R.; Cotman, C. W. Beta-amyloid-induced changes in cultured astrocytes parallel reactive as-trocytosis associated with senile plaques in Alzheimer's disease. Neuroscience 63:517-531; 1994.
75. 75. Pike, C. J.; Walencewicz, A. J.; Glabe, C. G.; Cotman, C. W. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur. J. Pharmacol. 207:367-368; 1991.
76. 76. Pike, C. J.; Walencewicz, A. J.; Glabe, C. G.; Cotman, C. W. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563:311-314; 1991.
77. 77. Probst, A.; Brunnschweiler, H.; Lautenschlager, C.; Ulrich. J. A special type of senile plaque, possibly an initial stage. Acta Neuropathol. (Berl.) 74:133-141; 1987.
78. 78. Ramon y Cajal, S. Degeneration and regeneration of the nervous system. London: Oxford University Press, Humphrey Milford; 1928.
79. 79. Rich, J. B.; Rasmusson, D. X.; Folstein, M. F.; Carson, K. A.; Kawas, C.; Brandt, J. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neurology 45:51-55; 1995.
80. 80. Rio-Hortega, P. D. Microglia. In: Courville, C. B., eds. Cytology and cellular pathology of the nervous system. New York: Hocker; 1932: 481-584.
81. 81. Rivera, S.; Gold, S. J.; Gall, C. M. Interleukin-1 beta increases basic fibroblast growth factor mRNA expression in adult rat brain and organo-typic hippocampal cultures. Brain Res. Mol. Brain Res. 27:12-26; 1994.
82. 82. Rogers, J.; Cooper, N. R.; Webster, S.; Schultz, J.; McGeer, P. L.; Styren, S. D.; Civin, W. H.; Brachova, L.; Bradt, B.; Ward, P.; et al. Complement activation by beta-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 89:10016-10020; 1992.
83. 83. Shigematsu, K.; McGeer, P. L.; Walker, D. G.; Ishii, T.; McGeer, E. G. Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage. J. Neurosci. Res. 31:443-453; 1992.
84. 84. Smith, M. E. Phagocytosis of myelin by microglia in vitro. J. Neurosci. Res. 35:480-187; 1993.
85. 85. Smyth, M. D.; Cribbs, D. H.; Tenner, A. J.; Shankle, W. R.; Dick, M.; Kesslak, J. P.; Cotman, C. W. Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol. Aging 15:609-614; 1994.
86. 86. Tenner, A. J.; Cooper, N. R. Stimulation of a human polymorpho-nuclear leukocyte oxidative response by the C1q subunit of the first complement component. J. Immunol. 128:2547-2552; 1982.
87. 87. Veerhuis, R.; van der Valk, P.; Janssen, I.; Zhan, S, S.; Van Nostrand, W. E.; Eikelenboom, P. Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3. Virchows Arch. 426:603-610; 1995.
88. 88. Veerhuis, R.; Van Es, L. A.; Daha, M. R. Effects of soluble aggregates of IgG on the binding, uptake and degradation of the C1q subcomponent of complement by adherent guinea pig peritoneal macrophages. Eur. J. Immunol. 15:881-887; 1985.
89. 89. Whitson, J. S.; Glabe, C. G.; Shintani, E.; Abcar, A.; Cotman, C. W. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci. Lett. 110:319-324; 1990.
90. 90. Whitson, J. S.; Selkoe, D. J.; Cotman, C. W. Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science 243: 1488-1490; 1989.
91. 91. Wisniewski, H. M.; Terry, R. D. Reexamination of the pathogenesis of the senile plaque. In: Zimmerman, H. M., eds. Progress in neuropathology. New York: Grune & Stratton; 1973:1-26.
92. 92. Wisniewski, H. M.; Weigel, J. Migration of perivascular cells into the neuropil and their involvement in beta-amyloid plaque formation. Acta Neuropathol. (Berl.) 85:586-595; 1993.
93. 93. Yankner, B. A.; Duffy, L. K.; Kirschner, D. A. Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides. Science 250:279-282; 1990.
94. 94. Yao, J.; Harvath, L.; Gilbert, D. L.; Colton, C. A. Chemotaxis by a CNS macrophage, the microglia, J. Neurosci. Res. 27:36-42; 1990.
95. 95. Yao, J.; Keri, J. E.; Taffs, R. E.; Colton, C. A. Characterization of interleukin-1 production by microglia in culture. Brain Res. 591:88-93; 1992.
96. 96. Yoshida, K.; Gage, F. H. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res. 538: 118-126; 1991.