Long-lasting benefits after treatment of traumatic brain injury (TBI) in rats with combination therapy of marrow stromal cells (MSCs) and simvastatin

Journal of Neurotrauma

Volumn 25, Issue 12, 2008, Pages 1441-1447

  Mahmood, Asim ^a   Goussev, Anton ^a   Lu, Dunyue ^b   Qu, Changsheng ^a   Xiong, Ye ^a   Kazmi, Humaira ^a   Chopp, Michael ^c,d  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c HENRY FORD HOSPITAL   (United States)

^d OAKLAND UNIVERSITY   (United States)

Author keywords

Combination therapy; Marrow stromal cells (MSCs); Simvastatin; Traumatic brain injury (TBI)

Indexed keywords

EOSIN; HEMATOXYLIN; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BONE MARROW CELL; BRAIN CORTEX; BRAIN DAMAGE; BRAIN FUNCTION; BRAIN SLICE; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OUTCOME ASSESSMENT; RAT; STROMA CELL; TISSUE SECTION; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; COMBINED MODALITY THERAPY; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SIMVASTATIN; STROMAL CELLS; TIME FACTORS; TREATMENT OUTCOME;

EID: 59649123631     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2007.0495     Document Type: Article

References (23)

1. Ballantyne, C.M., Blazing, M.A., King, T.R., Brady, W.E., and Palmisano, J. (2004). Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am. J. Cardiol. 93, 1487-1494.
2. Cameron, H.A., and McKay, R.D.G. (2001). Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435, 406-417.
3. Dixon, C.E., Clifton, G.L., Lighthall, J.W., Yaghmai, A.A., and Hayes, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
4. Leventhal, C., Rafii D, Shahar, A., and Goldman, S.A. (1999). Endothelial trophic support of neuronal production of recruitment from the adult mammalian subependyma. Mol. Cell Neurosci. 13, 450-464.
5. Li, Y., Chen, J., Chen, X.G., Wang, L., Gautam, S.C., Xu, X.Y., Katakowski, M., Zhang, L.J., Lu, M., Janakiraman, N., and Chopp, M. (2002). Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 59, 514-523.
6. Lu, D., Li, Y., Wang, L., Chen, J., Mahmood, A., and Chopp, M. (2001a). Intraarterial administration of marrow stromal cells in rat model of traumatic brain injury. J. Neurotrauma 18, 813-819.
7. Lu, D., Mahmood, A., Li, Y., and Chopp, M. (2001b). Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12, 559-563.
8. Lu, D., Mahmood, A., and Chopp, M. (2003). Biological transplantation and neurotrophic induced neuroplasticity after traumatic brain injury. J. Head Trauma Rehabil. 18, 357-376.
9. Lu, D., Goussev, A., Chen, J., Pannu, P., Li, Y., Mahmood, A., and Chopp, M. (2004a). Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis and neuronal survival in rats subjected to traumatic brain injury. J. Neurotrauma 21, 21-32.
10. Lu, D., Mahmood, A., Goussev, A., Qu, C., Zhang, Z.G., and Chopp, M. (2004b). Delayed thrombosis after traumatic brain injury in rats. J. Neurotrauma 21, 1756-1766.
11. Lu, D., Mahmood, A., Goussev, A., Schallert, T., Qu, C., Zang, Z.G., Li, Y., Lu, M., and Chopp, M. (2004c). Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury. J. Neurosurg. 101, 819-827.
12. Lu, D., Qu, C., Goussev, A., Jiang, H., Lu, C., Schallert, T., Mahmood, A., Chen, J., Li, Y., and Chopp, M. (2007). Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J. Neurotrauma 24, 1132-1146.
13. Mahmood, A., Lu, D., Wang, L., and Chopp, M. (2001). Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery 49, 1196-1204.
14. Mahmood, A., Lu, D., Li, Y., and Chopp, M. (2002). Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. J. Neurotrauma 19, 1609-1617.
15. Mahmood, A., Lu, D., and Chopp, M. (2003). Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 53, 697-703.
16. Mahmood, A., Lu, D., and Chopp, M. (2004). Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation with the brain. Neurosurgery 55, 1185-1193.
17. Mahmood, A., Lu, D., Qu, C., Goussev, A., and Chopp, M. (2005). Human marrow stromal cell treatment provides long lasting benefit after traumatic brain injury in rats. Neurosurgery 57, 1026-1031.
18. Mahmood, A., Lu, D., Qu, C., Goussev, A., and Chopp, M. (2006). Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats. J. Neurosurg. 104, 272-277.
19. Mahmood, A., Lu, D., Qu, C., Goussev, A., and Chopp, M. (2007). Treatment of traumatic brain injury in rats with a combination therapy of marrow stromal cells (MSCs) and atorvastatin. Neurosurgery 60, 546-553.
20. Postmantur, R., Kampfl, A., Simon, R., Liu, J., Zhao, X., Clifton, G.L., and Hayes, R.L. (1997). A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77, 875-888.
21. Shohami, E., Novikov, M., and Bass, R. (1995). Long term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. 674, 55-62.
22. Yurek, D.M., Lu, W., Hipkens, S., and Wiegand, S.J. (1996). BDNF enhances the functional reinervation of the striatum by grafted fetal dopamine neurons. Exp. Neurol. 137, 105-118.
23. Zacco, A., Togo, J., Spence, K., Ellis, A., Lloyd, P., Furlong, S., and Pisa, T. (2003). 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J. Neurosci. 23, 11104-11111.