Presenilin redistribution associated with aberrant cholesterol transport enhances β-amyloid production in vivo

Journal of Neuroscience

Volumn 23, Issue 13, 2003, Pages 5645-5649

  Burns, Mark ^a,b   Gaynor, Kate ^a   Olm, Vicki ^a   Mercken, Marc ^c   LaFrancois, John ^a   Wang, Lili ^a   Mathews, Paul M ^a,b   Noble, Wendy ^a   Matsuoka, Yasuji ^a,b   Duff, Karen ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Amyloid; Cholesterol; Endosome; Niemann Pick; NPC; Presenilin; Rab 5; CTF; secretase

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; BETA SECRETASE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOSOME; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; LYSOSOME; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING;

EID: 0038045571     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-13-05645.2003     Document Type: Article

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