Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4496-4508

  Dossi, Kyriaki ^a   Tsirkone, Vicky G ^a   Hayes, Joseph M ^a   Matoušek, Josef ^b   Poučková, Pavla ^c   Souček, Josef ^d   Zadinova, Marie ^c   Zographos, Spyros E ^a   Leonidas, Demetres D ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

Author keywords

ADME properties; Bovine seminal ribonuclease; Drug design QikProp; Enzyme inhibition

Indexed keywords

3' CYTIDYLIC ACID; CYTIDINE 5 PHOSPHATE; RIBONUCLEASE A; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG; URIDINE 2' PHOSPHATE; URIDINE 3' PHOSPHATE; URIDINE DIPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; COW; CRYSTAL STRUCTURE; DRUG ADSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME BINDING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; X RAY CRYSTALLOGRAPHY;

EID: 70349780428     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.039     Document Type: Article

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