Ribonucleases and their antitumor activity

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 129, Issue 3, 2001, Pages 175-191

  Matoušek, Josef ^a  

^a INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

Author keywords

Angiogenin; Antitumor; Conjugation; Enzyme; Onconase; Polymer; Recombinant; Ribonuclease; Synthetic genes

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOGENIN; IMMUNOTOXIN; PANCREATIC RIBONUCLEASE; POLYMER; RANPIRNASE; RIBONUCLEASE; SYNTHETIC DNA; TUMOR ANTIGEN;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; BLOOD; CONJUGATION; ENZYME ACTIVITY; GENE SEQUENCE; HALF LIFE TIME; HUMAN; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR GROWTH; VASCULARIZATION;

ANIMALIA; BOVINAE;

EID: 0034918691     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1532-0456(01)90202-9     Document Type: Review

References (143)

1. Full antitumor action of recombinant seminal ribonuclease depends on the removal of its N-terminal methionine
2. Intracutaneous ribonuclease in chronic myelocytic leukaemia
3. Amino acid sequence of an anti-tumor protein from Rana pipiens oocytes and early embryos. Homology to pancreatic ribonucleases
4. Enzymatic characterization of onconase, a novel ribonuclease with antitumour activity
5. Angiogenin, a potent mediator of angiogenesis. Biological, biochemical and structural properties
6. Activity of recombinant mitogillin and mitogillin immunoconjugates
7. Pancreatic ribonucleases
8. Tumor interactions with the vasculature: Angiogenesis and tumor metastasis
9. Role of the N-terminus in RNase A homologues. Differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity
10. A ribonuclease A variant with low catalytic activity but high cytotoxicity
11. Circular dichroism study of ribonuclease A mutants containing the minimal structural requirements for dimerization and swapping
12. From ribonuclease A toward bovine seminal ribonuclease: A step by step thermodynamic analysis
13. Superadditive and subadditive effects of 'hat spot' mutation within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A
14. + hematopoietic progenitor cells
15. Bovine seminal ribonuclease selectively kills human multidrugresistant neuroblastoma cells via induction of apoptosis
16. Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs
17. Action of A RNase and AS RNase on growth of cells in vitro
18. The action of seminal enzymes on ribonucleic acid
19. Bull seminal ribonucleases. 1. Purification and physicochemical properties of the major component
20. Seminal RNase: A unique member of the ribonuclease superfamily
21. Cytostatic and cytotoxic effect of Pannon (P-30 Protein) a novel anticancer agent
22. Action of deoxyribonuclease and ribonuclease on the growth of Ehrlich ascites carcinoma in mice
23. Expression of bovine seminal ribonuclease in Escherichia coli
24. Engineering ribonuclease A: Production, purification, and characterization of wild-type enzyme and mutants at Gln 11
25. Design, characterization and anti-tumor cytotoxicity of a panel of recombinant, mammalian ribonuclease-based immunotoxins
26. Antiplacental alkaline phosphatase single-chain Fv: Redesigned solubility, characterization and in vivo tumor targeting
27. Potentiation of tumor necrosis factor induced apoptosis by onconase
28. Hints on the evolutionary design of dimeric RNase with special bioactions
29. Purification of aspermatogenic substance (AS) from the bull seminal vesicle fluid
30. An immunohistological study of testicular germ cell tumors using two different monoclonal antibodies against placental alkaline phosphatase
31. Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells
32. A new remote subsite in ribonuclease A
33. Tumor angiogenesis: Therapeutic implications
34. Tumor angiogenesis factor
35. Angiogenesis; initiation and control
36. Immunotoins in the therapy of cancer: From bench to clinic
37. Anti-angiogenin activity of the peptides complementary to the receptor-binding site of angiogenin
38. Development of antiangiogenin peptide using a phage-displayed peptide library
39. Structural versatility of bovine ribonuclease A: Distinct conformers of trimeric and tetrameric aggregates of the enzyme
40. + progenitor cells: Feasibility and purging efficacy in pediatric patients with neuroblastoma
41. Ribonuclease inhibitor
42. Purification and properties of seminal vesicle ribonucleases
43. Limited proteolysis of angiogenin by elastase is regulated by plasminogen
44. Structures and functions of ribonucleases
45. Biochemistry of frog ribonucleases
46. Bovine seminal ribonuclease produced from a synthetic gene
47. Variants of ribonuclease inhibitor that resist oxidation
48. Catalytic activity of bovine seminal ribonuclease is essential for its immunosuppressive and other biological activities
49. Structural basis for the biological activities of bovine seminal ribonuclease
50. Seminal-type ribonuclease genes in ruminants, sequence conservation without protein expression?
51. Conformational stability is a determinant of ribonuclease A cytotoxicity
52. Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A
53. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A
54. Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor
55. In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors
56. Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis Lung Carcinoma
57. Isolation and nucleotide sequence of the Aspergillus restrictus gene coding for the ribonucleotic toxin restrictocin and its expression in Aspergillus nidulans: The leader sequence protects producing strains from suicide
58. Action of ribonuclease on two solid tumors in vivo
59. Action of ribonuclease on neoplastic growth. I. Chemical aspects of normal tumor growth: The Landschütz ascites tumour
60. Structure and action of mammalion ribonuclease (angiogenin) inhibitor
61. Ribonuclease A variants with potent cytotoxic activity
62. Implications for the unique functional properties of an enzyme involved in neovascularisation during tumor growth
63. Revisiting the action of bovine ribonuclease A and pancreatic-type ribonucleases on double-stranded RNA
64. Characterization of the mechanism of cellular and cell free protein synthesis inhibited by an anti-tumor ribonuclease
65. Cytotoxic effects of eosinophil cationic protein on carcinoma cells
66. Bovine seminal ribonuclease induces in vitro concentration dependent apoptasis in stimulated human lymphocytes and cells from human tumor cell lines
67. Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease
68. Antigenicity of the seminal vesicle fluids in bulls
69. The effect of bovine seminal ribonuclease (AS RNase) on cells of Crocker tumor in mice
70. Embryotoxic effect of bull seminal ribonuclease and tissue absorption studies in rats
71. Action of bull seminal vesicle ribonuclease on mouse leukaemic cells BP8 and EL-4
72. Immunosuppressive activity of angiogenin in comparison with bovine seminal ribonuclease and pancreatic ribonuclease
73. Effect of bovine seminal ribonuclease (BS-RNase) on pig's bone marrow cells
74. Sulfur shuffle: Modulating enzymatic activity by thioldisulfide interchange
75. Bovine seminal ribonuclease attached to nanoparticles made of polylactic acid kills leukemia and lymphoma cell lines in vitro
76. Synergism between a novel amphibian oocyte ribonuclease and lovastin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines
77. Phase I human clinical trial of onconase (P-30 protein) administered intravenously on a weekly schedule in cancer patients with solid tumors
78. Onconase and doxorubicin synergy in prolonging survival of MDA-MR-231 human breast cancer bearing nude mice
79. Basic homopolyamino acids, histones and protamines are potent antagonists of angiogenin binding to ribonuclease inhibitor
80. Refined 1.7 A X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity
81. Sensitivity of monomeric and dimeric forms of bovine seminal ribonuclease to human placental ribonuclease inhibitor
82. Effects of protein RNase inhibitor and substrate on the quaternary structures of bovine seminal RNase
83. Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence
84. Unique recombinant human ribonuclease and inhibition of Kaposi's sarcoma cell growth
85. Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophilderived neurotoxin anti-transferring receptor sFv
86. Anti-tumor ribonuclease, combined with or conjugated to monoclonal antibody MRK 16, overcomes multidrug resistance to vincristine in vitro and in vivo
87. Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: Potential for the treatment of non-Hodkin lymphoma
88. Characterization of a Rana catesbeiana lectin-resistant mutant of leukaemia P388 cells
89. Alpha sarcin a new antitumor agent. II. Fermentation and antitumor spectrum
90. A monoclonal antibody to human angiogenin suppresses tumor growth in athymic mice
91. Angiogenin antagonists prevent tumor growth in vivo
92. Origin of the catalytic activity of bovine seminal ribonuclease against double-stranded RNA
93. Conjugates of semitelechelic poly [N-(2-hydroxypropyl) methacrylamide] with enzymes for protein delivery
94. Sequence analysis of a cloned cDNA coding for bovine seminal ribonuclease
95. Recombinant toxins as a novel therapeutic agent
96. Chimeric anti-angiogenin antibody cAb26-2F inhibits the formation of human breast cancer xenografts in athymic mice
97. A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells
98. A ribonuclease inhibitor expresses anti-angiogenic properties and leads to reduced tumor growth in mice
99. Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma
100. His-Asp catalytic dyad of ribonuclease A: Conformational stability of the wild-type, D121N, D121A and H 119A enzymes
101. Ribonuclease A
102. Structure and function of angiogenin
103. Eosinophil ribonucleases and host defense: Solving the puzzle
104. Ribonuclease activity and cancer: A review
105. Expression of native dimmers of bovine seminal ribonuclease in an eukaryotic cell system
106. In vitro evolution of a dimeric variant of human pancreatic ribonuclease
107. Base cleavage specificity of angiogenin with Saccharomyces cerevisiae and Escherichia coli 5S RNAs
108. Cytotoxic potential of RNase and RNase hybrid proteins
109. Humanization of immunotoxins
110. Enhancement of vincristine cytotoxicity in drug-resistant cell by simultaneous treatment with Onconase, an anti-tumor ribonuclease
111. Antibody target ribonucleases for cancer therapy
112. An anti-A-like lectin of Rana catesbeiana eggs showing unusual reactivity
113. Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily
114. Specific cleavage of ribosomal RNA caused by alpha sarcin
115. Isolation of angiogenin from normal human plasma
116. Serum level of angiogenin in breast cancer
117. Bovine seminal RNase induces apoptosis in normal proliferating lymphocytes
118. Effect of bovine seminal ribonuclease and bovine pancreatic ribonuclease A on bovine oocyte maturation
119. The binding of bull seminal ribonuclease and its carboxymethylated derivative to human leukaemic cells
120. Immunosuppressive effect of bovine seminal fluid fractions with ribonuclease activity
121. Effect of ribonucleases on cell mediated lympholysis reaction and on GM-CFC colonies in bone marrow culture
122. Anti-tumor action of bovine seminal ribonuclease
123. Structural changes to ribonuclease A and their effects on biological activity
124. + hematopoietic progenitor cells with recombinant immunotoxins
125. The effect of bull seminal vesicle ribonuclease on cells of Walker carcinosarcoma and Sajdel hepatoma of rats
126. The angiogenins
127. Engineering receptor-mediated cytotoxicity in human ribonucleases by steric blockade of inhibitor interaction
128. Immunosuppressive activity of bovine seminal RNase on T-cell proliferation
129. Three-dimensional structure of the complex of ribonuclease A with 2′, 5′ Cp A and 3′5′-d (CPA) in aqueous solution as obtained by NMR and restrained molecular dynamics
130. Pseudogenes in ribonuclease evolution: A source of new biomacromolecular function?
131. Poly [N-(2-hydroxypropyl) methacrylamide] conjugates of bovine seminal ribonuclease. Synthesis, physicochemical, and preliminary biological evaluation
132. Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily
133. Interferon enhances the activity of the anticancer ribonuclease, onconase
134. Crystal structure of a hybrid between, ribonuclease A and bovine seminal ribonuclease, the basic surface, at 2.0 angstrom resolution
135. In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease
136. Tissue distribution and developmental expression of messenger RNA encoding angiogenin
137. Structure and mechanism of action of the cytotoxic ribonuclease α-sarcin
138. A cytotoxic ribonuclease: Study of the mechanism of onconase cytotoxicity
139. A study of the intracellular routing of the cytotoxic ribonucleases
140. Antitumor RNases
141. Cytotoxic ribonucleases and chimeras in cancer therapy
142. Angiogenic growth factors in neural embryogenesis and neoplasia