Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: Synthesis, biochemical, and crystallographic evaluation

Journal of Medicinal Chemistry

Volumn 52, Issue 4, 2009, Pages 932-942

  Samanta, Anirban ^a   Leonidas, Demetres D ^b   Dasgupta, Swagata ^a   Pathak, Tanmaya ^a   Zographos, Spyros E ^b   Oikonomakos, Nikos G ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b INSTITUTE OF BIOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 5' DEOXY 5' N (ETHYL ISONIPECOTATYL)URIDINE; 5' DEOXY 5' N MORPHOLINOURIDINE; ANGIOGENIN; OXYGEN; PHOSPHORUS; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RIBONUCLEASE A; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL BOND; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; NEOVASCULARIZATION (PATHOLOGY); STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR VASCULARIZATION; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINE NUCLEOSIDES; PYRROLIDINES; RIBONUCLEASE, PANCREATIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64349092838     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800724t     Document Type: Article

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