High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors

Protein Science

Volumn 12, Issue 11, 2003, Pages 2559-2574

  Leonidas, Demetres D ^a   Chavali, Gayatri B ^b,d   Oikonomakos, Nikos G ^a   Chrysina, Evangelia D ^a   Kosmopoulou, Magda N ^a   Vlassi, Metaxia ^c   Frankling, Claire ^b   Acahrya, K Ravi ^b  

^a INSTITUTE OF BIOLOGY   (Greece)

^b University of Bath   (United Kingdom)

^c INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Angiogenin; Eosinophil cationic protein; Eosinophil derived neurotoxin; Ribonuclease A inhibitors; Structure aided drug design

Indexed keywords

5' DIPHOSPHOADENOSINE 3' PHOSPHATE; 5' PHOSPHO 2' DEOXYURIDINE 3 PYROPHOSPHATE; ADENOSINE 2',5' DIPHOSPHATE; ADENOSINE 3' PHOSPHATE; ADENOSINE 3',5' DIPHOSPHATE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ANGIOGENIN; EOSINOPHIL CATIONIC PROTEIN; EOSINOPHIL PROTEIN X; RIBONUCLEASE A; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

ADENOSINE DIPHOSPHATE; ANIMALS; BINDING SITES; BLOOD PROTEINS; CATTLE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; EOSINOPHIL GRANULE PROTEINS; EOSINOPHIL-DERIVED NEUROTOXIN; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES; URACIL NUCLEOTIDES;

BOVINAE;

EID: 0142210123     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03196603     Document Type: Article

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