Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant

Protein Science

Volumn 18, Issue 1, 2009, Pages 50-57

  Merlino, Antonello ^a   Avella, Giovanna ^a   Di Gaetano, Sonia ^b   Arciello, Angela ^a   Piccoli, Renata ^a,c   Mazzarella, Lelio ^a,b   Sica, Filomena ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

3D domain swapping; Antitumor agents; Crystal structure; Dimers; Ribonuclease

Indexed keywords

CYSTEINE; DIMER; LEUCINE; PANCREATIC RIBONUCLEASE;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME ENGINEERING; ENZYME STABILITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN QUATERNARY STRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CRYSTALLOGRAPHY, X-RAY; ENDORIBONUCLEASES; HUMANS; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RIBONUCLEASE, PANCREATIC;

BOVINAE;

EID: 58149471086     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.6     Document Type: Article

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