Toward rational design of ribonuclease inhibitors: High-resolution crystal structure of a ribonuclease a complex with a potent 3',5'- pyrophosphate-linked dinucleotide inhibitor

Biochemistry

Volumn 38, Issue 32, 1999, Pages 10287-10297

  Leonidas, Demetres D ^a   Shapiro, Robert ^b   Irons, Laurence I ^a   Russo, Nello ^b,c   Acharya, K Ravi ^a  

^a University of Bath   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; DINUCLEOTIDE; NEUROTOXIN; PYROPHOSPHORIC ACID DERIVATIVE; RIBONUCLEASE A; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HYPEREOSINOPHILIA; NEOVASCULARIZATION (PATHOLOGY); NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ADENOSINE DIPHOSPHATE; ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; ENZYME INHIBITORS; EOSINOPHIL-DERIVED NEUROTOXIN; EOSINOPHILS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; NEUROTOXINS; NUCLEIC ACID CONFORMATION; PROTEINS; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES;

EID: 0033543235     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990900w     Document Type: Article

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