Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice

Anti-Cancer Drugs

Volumn 13, Issue 2, 2002, Pages 149-154

  Michaelis, Martin ^a   Cinatl, Jindrich ^a   Cinatl, Jaroslav ^a   Pouckova, Pavia ^a   Langer, Klaus ^a   Kreuter, Jörg ^a   Matousek, Josef ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Aspermatogenicity, BS RNase, neuroblasto ma; Polyethylene glycol

Indexed keywords

BOVINE SEMINAL RIBONUCLEASE; CONJUGATED BOVINE SEMINAL RIBONUCLEASE PLUS POLYETHYLENE GLYCOL; MACROGOL; RIBONUCLEASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG CONJUGATION; DRUG EFFICACY; HUMAN; HUMAN CELL; INTRASCROTAL DRUG ADMINISTRATION; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; SCROTUM; SEMINAL VESICLE; TUMOR GROWTH; XENOTRANSPLANTATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; ENDORIBONUCLEASES; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; INJECTIONS; MALE; MICE; MICE, INBRED STRAINS; NEUROBLASTOMA; POLYETHYLENE GLYCOLS; SEMINIFEROUS TUBULES; TUMOR CELLS, CULTURED;

EID: 0036188810     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200202000-00006     Document Type: Article

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