Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking

Biochemistry

Volumn 42, Issue 22, 2003, Pages 6674-6687

  Jenkins, Jeremy L ^a,b   Shapiro, Robert ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Center for Biochemical and Biophysical Sciences and Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; MOLECULAR DYNAMICS; TUMORS;

SMALL-MOLECULE INHIBITORS;

BIOCHEMISTRY;

4,4' DICARBOXY 3,3' BIS(NAPHTHYLAMIDO)DIPHENYLMETHANONE; 8 AMINO 5 (4' HYDROXYBIPHENYL 4 YLAZO)NAPHTHALENE 2 SULFONATE; ANGIOGENIN; ANGIOGENIN ANTAGONIST; C 181431; METHANOL DERIVATIVE; NSC 65828; RIBONUCLEASE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; BINDING SITES; BINDING, COMPETITIVE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0038661289     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034164e     Document Type: Article

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