Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity

Xenobiotica

Volumn 39, Issue 8, 2009, Pages 625-635

  Lewis, D F V ^a   Ito, Y ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Binding affinity; Human cytochrome P450s; Substrate selectivity

Indexed keywords

2 AMINO 3,4 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; 3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; 4 NITROPHENOL; AMFEBUTAMONE; AMODIAQUINE; ARACHIDONIC ACID; CAFFEINE; CYTOCHROME P450; DICLOFENAC; ETHOXYRESORUFIN; FLUINDOSTATIN; FLURBIPROFEN; INDOLE; LOSIGAMONE; MEFENAMIC ACID; NAPROXEN; NICOTINE; NIFEDIPINE; OMEPRAZOLE; PHENYTOIN; PROGUANIL; PROPRANOLOL; QUINOLINE; ROSIGLITAZONE; SELEGILINE; TIENILIC ACID; TOLBUTAMIDE; TORASEMIDE; UNINDEXED DRUG; WARFARIN; DRUG;

BINDING AFFINITY; CRYSTAL STRUCTURE; DEMETHYLATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HYDROXYLATION; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR MODEL; OXIDATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

MAMMALIA;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 70349576221     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250903000255     Document Type: Review

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