Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: Identification of a new high affinity substrate common to those enzymes

Biochemistry

Volumn 42, Issue 21, 2003, Pages 6363-6369

  Marques Soares, Cristina ^a   Dijols, Sylvie ^a   Macherey, Anne Christine ^a   Wester, Michael R ^b   Johnson, Eric F ^b   Dansette, Patrick M ^a   Mansuy, Daniel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; ENZYMES; HYDROXYLATION; OXIDATION; SUBSTRATES;

INHIBITORY EFFECTS;

PIGMENTS;

ALKYL GROUP; AMMONIA; BENZYL DERIVATIVE; CYTOCHROME P450 2C; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C5; CYTOCHROME P450 2C5DH; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3LVDH; ISOENZYME; LIVER ENZYME; METHYL GROUP; PHENYL GROUP; SULFAPHENAZOLE; SULFAPHENAZOLE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; CATALYST; CHEMICAL BINDING; CHEMICAL REACTION; COMPLEX FORMATION; ELECTRIC POTENTIAL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; IC 50; METHYLATION; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANTI-INFECTIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; BIOCHEMISTRY; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIVER; MICROSOMES; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; OXYGEN; PROGESTERONE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STEROID 21-HYDROXYLASE; SUBSTRATE SPECIFICITY; SULFAPHENAZOLE; SULFONAMIDES; ULTRAVIOLET RAYS;

ORYCTOLAGUS CUNICULUS;

EID: 0038687263     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027391+     Document Type: Article

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