A unified theory of enzyme kinetics based upon the systematic analysis of the variations of kcat, KM, and kcat/KM and the relevant ΔG0≠ values - Possible implications in chemotherapy and biotechnology

Biochemical Pharmacology

Volumn 61, Issue 9, 2001, Pages 1049-1055

  Bauer, Carlo ^a   Osman, Ahmed M ^b   Cercignani, Giovanni ^a   Gialluca, Natalino ^a   Paolini, Moreno ^c  

^a UNIVERSITY OF PISA   (Italy)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Enzymatic engineering; Enzyme evolution; Enzyme specificity; Free energy; Inhibitors and activators; Kinetic properties

Indexed keywords

ISOENZYME;

BIOTECHNOLOGY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SPECIFICITY; MICHAELIS CONSTANT; PRIORITY JOURNAL; REVIEW;

EID: 0035342270     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00579-2     Document Type: Article

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