Cytochrome P450 structures and their substrate interactions

Drug Development Research

Volumn 66, Issue 1, 2005, Pages 19-24

  Lewis, David F V ^a   Ito, Yuko ^b   Goldfarb, Peter S ^c  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^c NONE

Author keywords

Cytochromes P450 structures; New chemical entity; Substrate binding

Indexed keywords

4 PHENYLIMIDAZOLE; CAMPHOR; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 2C5; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2F1; CYTOCHROME P450 3A4; DICLOFENAC; FLURBIPROFEN; IBUPROFEN; MYRISTIC ACID; NITRIC OXIDE; OXYGEN; PHENYTOIN; TIENILIC ACID; TOLBUTAMIDE; TORASEMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

CRYSTAL STRUCTURE; DRUG METABOLISM; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; PROTEIN DOMAIN; PROTEIN FAMILY; REVIEW; X RAY CRYSTALLOGRAPHY; XENOBIOTIC METABOLISM;

EID: 32544442508     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.20040     Document Type: Review

References (30)

1. Anzenbacher P, Anzenbacherova E. 2001. Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 58:737-747.
2. Archakov AI, Bachmanova GI. 1990. Cytochrome P450 and active oxygen. London: Taylor & Francis.
3. Bernhardt R. 1995. Cytochrome P450: structure, function and generation of reactive oxygen species. Rev Physiol Biochem Pharmacol 127:137-221.
4. Domanski TL, Halpert JR. 2001. Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis. Curr Drug Metab 2:117-137.
5. Gibson GG, Skett P. 2001. Introduction to drug metabolism, 2nd ed. London: Nelson Thomas.
6. Guengerich FP. 2002. Cytochrome P450. In: Ioannides C, editor. Enzyme systems that metabolize drugs and other xenobiotics. New York Wiley. p 33-65.
7. Ioannides C. editor. 1996. Cytochromes P450: metabolic and toxicological aspects. Boca Raton: CRC Press.
8. Lewis DFV 1996. Cytochromes P450: structure, function and mechanism. London: Taylor & Francis.
9. Lewis DFV. 2001. Guide to Cytochromes P450 structure and function. London; Taylor & Francis.
10. Lewis DFV. 2002. Modelling human cytochromes P450 involved in drug metabolism from the CYP2C5 crystallographic template. J Inorg Biochem 91:502-514.
11. Lewis DFV. 2003. P450 structures and oxidative metabolism of xenobiotics. Pharmacogenomics 4:387-395.
12. Lewis DFV. 2004, 57 varieties: the human cytochromes P450. Pharmacogenomics 5:307-318.
13. Lewis DFV. Dickins M. 2003. Baseline lipophilicity relationshops in human cytochromes P450. Drug Metab Rev 35:1-18.
14. Lewis DFV, Hlavica P. 2000. Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects. Biochim Biophys Acta 1460:353-374.
15. Lewis DFV, Pratt JM. 1998. The P450 catalytic cycle and oxygenation mechanism. Drug Metab Rev 30:739-786.
16. Lewis DFV, Jacobs MN, Dickins M. 2004. Compound lipophilicity for substrate binding to human P450s in drug metabolism. Drug Discov Today 9:530-537.
17. Mancy A, Broto P, Dijols S, Dansette PM, Mansuy D. 1995. The substrate binding site of human liver cytochrome P450209: an approach using designed tienilic acid derivatives and molecular modeling. Biochemistry 34:10365-10375.
18. BM3 involves a 6 movement of the bound substrate on reduction. Nature Struct Biol 3:414-417.
19. Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ. 1998. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19:1639-1662.
20. Omura T, Ishimura Y, Fujii-Kuriyama Y, editors. 1993. Cytochrome P450. Tokyo: Kodansha.
21. Ortiz de Montellano PR, editor. 1986. Cytochrome P450. New York: Plenum Press.
22. Ortiz de Montellano PR, editor. 1995. Cytochrome P450, 2nd ed. New York: Plenum Press.
23. Ortiz de Montellano PR, editor. 2005. Cytochrome P450, 3rd ed, New York: Plenum Press.
24. Rendic S. 2002. Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabol Rev 34:83-448.
25. Rendic S, DiCarlo FJ. 1997. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers and inhibitors. Drug Metab Rev 29:413-580.
26. Ruckpaul K, Rein H, editors. 1984. Cytochrome P450. Berlin: Akademie-Verlag.
27. Schenkman JB, Griem H, editors. 1993. Cytochrome P450. Berlin: Springer-Verlag.
28. 359 variants: enzyme kinetic study with seven substrates. Pharmacogenetics 10:95-104.
29. Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H. 2004. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science 305:683-686.
30. Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF 2004. The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 resolution. J Biol Chem 279:38091-38094.