Cytogenetic perspective of ageing and longevity in men and women

Journal of Applied Genetics

Volumn 50, Issue 3, 2009, Pages 261-273

  Zietkiewicz E ^a   Wojda, A ^a   Witt, M ^a,b  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

Aneuploidy; Centenarians; Chromosomal aberrations; DNA damage; Gender; Genomic instability; Lymphocyte; Micronuclei; Nondisjunction

Indexed keywords

EID: 69549131398     PISSN: 12341983     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03195682     Document Type: Article

References (128)

1. Abruzzo MA, Mayer M, Jacobs PA, 1985. Aging and aneuploidy: evidence for the preferential involvement of the inactive X chromosome. Cytogenet Cell Genet 39: 275-278.
2. Adler CP, Friedburg H 1986. Myocardial DNA content, ploidy level and cell number in geriatric hearts: post-mortem examinations of human myocardium in old age. J Mol Cell Cardiol 18: 39-53.
3. Akbari M and Krokan HE, 2008. Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging. Mech Ageing Dev 129: 353-365.
4. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N, 2004. Clinical phenotype of families with longevity. J Am Geriatr Soc 52: 274-277.
5. Atzmon G, Rincon M, Rabizadeh P, Barzilai N, 2005. Biological evidence for inheritance of exceptional longevity. Mech Ageing Dev 126: 341-345.
6. Bakou K, Stephanou G, Andrianopoulos C, Demopoulos NA, 2002. Spontaneous and spindle poison-induced micronuclei and chromosome non-disjunction in cytokinesis-blocked lymphocytes from two age groups of women. Mutagenesis 17: 233-239.
7. Balcombe NR, Sinclair A, 2001. Ageing: definitions, mechanisms and the magnitude of the problem. Best Pract Res Clin Gastroenterol 15: 835-849.
8. Beausejour C, 2007. Bone marrow-derived cells: the influence of aging and cellular senescence. Handb Exp Pharmacol 180: 67-88.
9. Berardi P, Russell M, El-Osta A, Riabowo K, 2004. Functional links between transcription, DNA repair and apoptosis. CMLS 61: 2173-2180.
10. Bergman A, Atzmon G, Ye K, MacCarthy T, Barzilai N, 2007. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput Bio. 3:e170.
11. Bird J, Ostler EL, Faragher RGA, 2003. Can we say that senescent cells cause ageing? Exp Geront 38: 1319-1326.
12. Bolognesi C, Abbondandolo A, Barale R, 1997. Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and MN in human lymphocytes. Cancer Epidemiol Biomarkers Prev 6: 249-256.
13. Bolognesi C, Lando C, Forni A, Landini E, Scarpato R, Migliore L, Bonassi S, 1999. Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes. Age Ageing 28: 393-397.
14. Brooks A, Lithgow GJ, Johnson TE, 1994. Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans. Science 263: 668-671.
15. Brugmans L, Kanaar R, Essers J, 2007. Analysis of DNA double-strand break repair pathways in mice. Mutat Res 614: 95-108.
16. Bukvic N, Gentile M, Susca F, Fanelli M, Serio G, Buonadonna L, et al. 2001. Sex chromosome loss, micronuclei, sister chromatid exchange and aging: a study including 16 centenarians. Mutat Res 498: 159-167.
17. Carere A, Antoccia A, Cimini D, Crebelli R, Degrassi F, Leopardi P, et al. 1999. Analysis of chromosome loss and non-disjunction in cytokinesis-blocked lymphocytes of 24 male subjects. Mutagenesis 14: 491-496.
18. Carey JR, Liedo P, Orzoco D, Vaupel JW, 1992. Slowing of mortality rates at older ages in large medfly cohorts. Science 258: 457-461.
19. Catalan J, Autio K, Wessman M, Lindholm C, Knuutilla S, Sorsa M, Norppa H, 1995. Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women. Cytogenet Cell Genet 68: 11-16.
20. Catalan J, Surralles J, Falck GCM, Autio K, Norppa H, 2000. Segregation of sex chromosomes in human lymphocytes. Mutagenesis 15: 251-255.
21. Chen JH, Hales CN, Ozanne SE, 2007. DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res 35: 7417-7428.
22. Davidovic M, 1999. Genetic stability: the key to longevity? Med Hypotheses 53: 329-332.
23. Davidovic M, Milosevic DP, Despotovic N, Sekularac N, Herceg P, 2007. Is there such a thing as "vaccine against ageing?" Adv Gerontol 20: 56-59.
24. Decordier I, Dillen L, Cundari E, Kirsch-Volders M, 2002. Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules. Mutagenesis 17: 337-344.
25. De Magalhaes JP, 2004. From cells to ageing: a review of models and mechanism of cellular senescence and their impact on human ageing. Exp Cell Res 300: 1-10.
26. De Magalhaes JP, 2005. Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Res Rev 4: 1-22.
27. Dutkowski RT, Lesh R, Staiano-Coico L, Thaler H, Darlington GJ, Weksler ME, 1985. Increased chromosomal instability in lymphocytes from elderly humans. Mutat Res 149: 505-512.
28. Effros RB, Dagarag M, Spaulding C, Man, J, 2005. The role ofCD8+T-cell replicative senescence in human aging. Immunol Rev 205: 147-157.
29. Fenech M, Morley AA, 1985. The effect of donor age on spontaneous and induced micronuclei. Mutat Res 148: 99-105.
30. Fenech M, Morley AA, 1986. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat Res 161: 193-198.
31. Fenech M, Morley AA, 1987. Ageing in vivo does not influence micronucleus induction in human lymphocytes by X-irradiation. Mech Ageing Dev 39: 113-119.
32. Fenech M, 1998. Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes - a biomarker for DNA damage in human populations. Mitat Res. 404: 155-165.
33. Finkel T, Serrano M, Blasco MA, 2007. The common biology of cancer and ageing. Nature 448: 767-774.
34. Franceschi C, Motta L, Motta M, Malaguarnera M, Capri M, Vasto S, Candore G, Caruso C, 2008. The extreme longevity: the state of the art in Italy. Exp Gerontol 43: 45-52.
35. Gadhia PK, 1998. Possible age-dependent adaptive response to a low dose of X-rays in human lymphocytes. Mutagenesis 13: 151-152.
36. Galloway SM, Buckton KE, 1978. Aneuploidy and aging: chromosome studies on a random sample of the population using G-banding. Cytogenet Cell Genet 20: 78-95.
37. Ganguly BB, 1993. Cell division, chromosomal damage and micronucleus formation in peripheral lymphocytes of healthy donors: related to donor's age. Mutat Res 295: 135-148.
38. Geigl JB, Langer S, Barwisch S, Pfleghaar K, Lederer G, Speicher R, 2004. Analysis of gene expression patterns and chromosomal changes associated with aging. Cancer Res 64: 8550-8557.
39. Geigl JB, Obenauf, AC, Schwarzbraun, T, Speicher MR, 2008. Defining 'chromosomal instability'. Trends Genet 24: 64-69.
40. Gerdes LU, Jeune B, Ranberg KA, Nybo H, Vaupel JW, 2000. Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene", not a "longevity gene". Genet Epidemiol 19: 202-210.
41. Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V, 2004. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 23: 2554-2563.
42. Gorbunova V, Seluanov A, 2005. Making ends meet in old age: DSB repair and aging. Mech Ageing Develop 126: 621-628.
43. Gorbunova V, Seluanov A, Mao Z, Hine C., 2007. Changes in DNA repair during aging. Nucleic Acids Res 35: 7466-7474.
44. Gorla GR, Malhi H, Gupta S, 2001. Polyploidy associated with oxidative injury attenuates proliferative potential of cell. J Cell Sci 114: 2943-2951.
45. Gottifredi V, Prives C, 2005. The S phase checkpoint: when the crowd meets at the fork. Cell Develop Biol 16: 355-368.
46. Guarente L, 1996. Do changes in chromosomes cause ageing? Cell 86: 9-12.
47. Gudmundsson H, Gudbjartsson DF, Frigge M, Gulcher JR, Stefansson K, 2000. Inheritance of human longevity in Iceland. Eur J Hum Genet 8: 743-749.
48. Guttenbach M, Schakiwski R, Schmid M, 1994. Aneuploidy and ageing: sex chromosome exclusion into micronuclei. Hum Genet 94: 295-298.
49. Guttenbach M, Koschorz B, Bernthaler U, Grimm T, Schmid M, 1995. Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei. Am J Hum Genet 57: 1143-1150.
50. Hando J, Nath J, Tucker J, 1994. Sex chromosomes, micronuclei and aging in women. Chromosoma 103: 186-192.
51. Harrison JC, Haber JE, 2006. Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 40: 209-235
52. Hasty P, 2005. The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and ageing: observations in human and mice. Mech Ageing Devel 126: 71-77.
53. Hjelmborg J, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M et al. 2006. Genetic influence on human lifespan and longevity. Hum Genet 119: 312-321.
54. Houtgraaf JH, Versmissen J, van der Giessen W, 2006. A concise review of DNA damage checkpoints and repair in mammalian cells. J Cardiovasc Revasc Med 7: 165-172.
55. Joaquin AM, Gollapudi S, 2001. Functional decline in aging and disease: a role for apoptosis. J AmGeriatr Soc 49: 1234-1240.
56. Kaufmann WK and Paules RS, 1996. DNA damage and cell cycle checkpoints. FASEB J 10: 238-247.
57. Kirsch-Volders M, Fenech M, 2001. Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 16: 51-58.
58. Kregel KC, Zhang HJ, 2007. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 292: R18-36.
59. Leach NT, Jackson-Cook C, 2001. The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei. Mutat Res 495: 11-19.
60. Lengauer C, Kinzler KW, Vogelstein B, 1998. Genetic instabilities in human cancers. Nature. 396: 643-9.
61. Levine AJ, 1997. P53, the cellular gatekeeper for growth and division. Cell 88:323-331.
62. Li H, Mitchell JR, Hasty P, 2008. DNA double-strand breaks: a potential causative factor for mammalian aging? Mech Ageing 129: 416-424.
63. Marlhens F, Achkar WA, Aurias A, Couturier J, Dutrillaux AM, Gerbault-Sereau M, et al. 1986. The rate of chromosome breakage is age dependent in lymphocytes of adult controls. Hum Genet 73: 290-297.
64. Martin GM, Bergman A, Barzilai N, 2007.Geneticdeterminants of human health span and life span: progress and new opportunities. PLoS Genet 3: e125.
65. Martin JM, Kellett JM, Kahn J, 1980. Aneuploidy in cultured human lymphocytes: age and sex differences. Age Ageing 9: 147-153.
66. Mclean AR and Michie CA, 1995. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci USA, 92: 3707-3711.
67. Meckert PC, Rivello HG, Vigliano C, González P, Favaloro R, Laguens R, 2005. Endomitosis and polyploidization of myocardial cells in the periphery of human acute myocardial infarction. Cardiovasc Res 67: 116-123.
68. Monti D, Salvioli S, Capri M, Malorni W, Straface E, Cossarizza A, et al. 2000. Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech Ageing Dev 21: 239-250
69. Mukherjee AB, Alejandro J, Payne S, Thomas S, 1996. Age-related aneuploidy analysis of human blood cells in vivo by FISH. Mech Ageing Dev 90: 145-156.
70. Mukherjee AB, Thomas S, 1997. A longitudinal study of human age-related chromosomal analysis in skin fibroblasts. Exp Cell Res 235: 161-169.
71. Nath J, Tucker JD, Hando JC, 1995. Y chromosome aneuploidy, micronuclei, kinetochores and aging in men. Chromosoma 103: 725-731.
72. Niida H, Nakanishi M, 2006. DNA damage checkpoints in mammals. Mutagenesis 21: 3-9.
73. Norppa H, Falck GC, 2003. What do human micronuclei contain? Mutagenesis 18:221-233.
74. Nowinski GP, Van Dyke DL, Tilley BC, Jacobsen G, Babu VR, Worsham MJ et al. 1990. The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history. Am J Hum Genet 46: 1101-1111.
75. Ogawa T, Kitagawa M, Hirokawa K, 2000. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech Ageing Dev 117: 57-68.
76. Palitti F, 2004. Mechanisms of formation of chromosomal aberrations: insight from studies with DNA repair-deficient cells. Cytogenet Genome Res 104: 95-99.
77. Patil CK, Saira MI, Campisi J, 2005. The thorny path linking cellular senescence to organismal aging. Mech Age Devel 126: 1040-1045.
78. Peace BE and Succop P, 1999. Spontaneous micronucleus frequency and age: what are normal values. Mutat Res 425: 225-230.
79. Pelicci PG, 2004. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J Clin Invest 113: 4-7.
80. Perls, T., Kunkel, L., Puca, A., 2002a. The genetics of aging. Curr Opinion Genet Dev 12: 362-369.
81. Perls T, Levenson R, Regan M, Puca A, 2002b. What does it take to live to 100? Mech Ageing Dev 123: 231-242.
82. Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, Bogan H et al. 2002. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci U S A 99: 8442-8447.
83. Peterson CL, Cote J, 2004. Cellular machineries for chromosomal DNA repair. Genes Dev 18: 602-616.
84. Pfeiffer P, Goedecke W, Obe G, 2000. Mechanism of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 15: 289-302.
85. Pfeiffer P, Goedecke W, Kuhfittig-Kulle S, Obe G, 2004. Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations. Cytogenet Genome Res 104: 7-13.
86. Polish Yearbook of Statistics, Central Statistical Office, Warsaw, 2006.
87. Prieur M, AlAchkar W, Aurias A, Couturier J, Dutrillaux AM, Dutrillaux B, et al. 1988. Acquired chromosome rearrangements in human lymphocytes: effect of aging. Hum Genet 79: 147-50.
88. Rabizadeh P, Barzilai N, 2005. Biological evidence for inheritance of exceptional longevity Mech Ageing Dev 126: 341-345.
89. Ramsey MJ, Moore DH, Briner JF, Lee DA, Olsen L, Senft JR, Tucker JD, 1995. The effect of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat Res 238: 95-106.
90. Ravid K, Lu J, Zimmet JM, Jones MR, 2002. Roads to polyploidy: the megakaryocyte example. J Cell Physiol 190: 7-20.
91. Rehen SK, Yung YC, McCreight M., Kaushal D, Yang AH, Almeida BS et al 2005. Constitutional aneuploidy in the normal human brain. J Neurosci 25: 2176-2180.
92. Richard F, Aurias A, Couturier J, Dutrillaux B, Flury-Herard A, Gerbault-Seureau M, et al. 1993. Aneuploidy in human lymphocytes: an extensive study of eight individuals of various age. Mutat Res 295: 71-80.
93. Richard F, Muleris M, Dutrillaux B, 1994.The frequency of micronuclei with X chromosome increases with age in human females. Mutat Res 316: 1-7.
94. Rodier F, Campisi J, Bhaumik D, 2007. Two faces of p53:aging and tumor suppression.Nucleic Acids Res 35: 7475-7484.
95. Russell LM, Strike P, Browne CE, Jacobs PA, 2007. X chromosome loss and ageing. Cytogenet Genome Res 116: 181-185.
96. Sablina AA, Ilyinskaya GV, Rubstova SN, Agapova LS, Chumakov PM, Kopnin BP, 1998. Activation of p53-mediated cell cycle checkpoint in response to micronuclei formation. J Cell Sci 111: 977-984.
97. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC, 2004. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable doublestrand breaks. Nat Cell Biol 6: 168-170.
98. Seluanov A, Mittelman D, Pereira-Smith OM, Wilson JH, Gorbunova V, 2004. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci USA 101:7624-7629.
99. Sieber OM, Heinimann K, Tomlinson IP, 2003. Genomic instability-the engine of tumorigenesis? Nat Rev Cancer 3: 701-708.
100. Sigurdson AJ, Ha M, Hauptmann M, Bhatti P, Sram RJ, Beskid O, et al. 2008. International study of factors affecting human chromosome translocations. Mutat Res 652: 112-121.
101. Skythe A, Pederesen NL, Kaprio J, Stazi MA, Hjelmborg JB, Iachine I et al. 2003. Longevity studies in GenomEUtwin. Twin Res 6: 448-454.
102. Solomon E, Borrow J, Goddard AD, 1991. Chromosome aberrations and cancer. Science 254: 1153-1160.
103. Stankovic T, Stewart GS, Fegan C, Biggs P, Last J, Byrd PJ, et al. 2002. Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood 99: 300-309.
104. Storchova Z, Pellman D, 2004. From polyploidy to aneuploidy, genome instability and cancer. Mol Cell Biol 5: 45-54.
105. Suh Y, Lee KA, Kim WH, Han BG, Vijg J, Park SC, 2002. Aging alters the apoptotic response to genotoxic stress. Nat Med 2002: 8: 3-4
106. Suh Y, Vijg J, 2006 Maintaining genetic integrity in aging: a zero sum game. Antioxid Redox Signal 8: 559-571.
107. Surralles J, Falck G, Norppa H, 1996. In vivo cytogenetic damage revealed by FISH analysis of micronuclei in uncultured human T lymphocytes. Cytogenet Cell Genet 75: 151-154.
108. Sutherland GR, Bake E, Richards RI, 1998. Fragile sites still breaking. Trends Genet 14: 501-506.
109. Tawn EJ, Whitehouse C, 2001. Frequencies of chromosome aberrations in a control population determined by G banding. Mut Res 490: 171-177.
110. Terry DF, Wyszynski DF, Nolan VG, Atzmon G, Schoenhofen EA, Pennington JY et al. 2006. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev 127: 862-868.
111. Tough DF, Sprent J, 1994. Turnover of naive- and memory-phenotype T cells. 179: 1127-1135.
112. Toussaint O, Dumont J, Remacle J, Dierick JF, Pascal T, Fippiat C, et al. 2002. Stress-induced premature senescence or stress-induced senescence-like phenotype: one in vivo reality, two possible definitions? Scientific World Journal 2: 230-247.
113. Tucker JD, Nath J, Hando JC, 1996. Activation status of the X chromosome in human micronucleated lymphocytes. Hum Genet 97: 471-475.
114. Valerie K, Povirk LF, 2003. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792-5812.
115. Vaupel JW, 1995. Exceptional longevity: from prehistory to the present. In: Jeune B, Vaupel JW, eds. Exceptional longevity: from prehistory to the present. Berlin: Springer.
116. Vijg J, 2004. Impact of genome instability on transcription regulation of aging and senescence. Mech Ageing Dev 125: 747-453.
117. Vijg J, Dollé ME, 2002. Large genome rearrangements as a primary cause of aging. Mech Ageing Dev 123: 907-915.
118. Vijg J, 2007. Aging of the genome: the dual role of DNA in life and death. Oxford Univ Press.
119. Vilenchik MM, Knudson AG, 2003. Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci USA 100: 12871-12876.
120. Vorobtsova I, Semenov A, Timofeyeva N, Kanayeva A, Zvereva I, 2001a. An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionizing radiation. Mech Ageing Dev 122: 1373-1382.
121. Vorobtsova I, Darroudi F, Semyonov A, Kanayeva A, Timofeyeva N, Yakovleva T, et al 2001b. Analysis of chromosome aberrations by FISH and Giemsa assays in lymphocytes of cancer patients undergoing whole-body irradiation: comparison of in vivo and in vitro irradiation. Int J Radiat Biol 77: 1123-1131.
122. Wallace DL, Zhang Y, Ghattas H, Worth A, Irvine A, Bennett AR, et al. 2004. Direct measurement of T cell subset kinetics in vivo in elderly men and women. 173: 1787-1794.
123. Whitehouse CA, Edwards AA, Tawn EJ, Stephan G, Oestreicher U, Moquet JE, et al. 2005. Translocation yields in peripheral blood lymphocytes from control populations. Int J Radiat Biol 81: 139-145.
124. Wojda A, Zietkiewicz E, Mossakowska M, Pawlowski W, Skrzypczak K, Witt M, 2006. Correlation between the level of cytogenetic aberrations in cultured human lymphocytes and the age and gender of donors. J Gerontol A Biol Sci Med Sci 61: 763-772.
125. Wojda A, Zietkiewicz E, Witt M, 2007. Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects. Mutagenesis 22: 195-200.
126. Zijno A, Leopardi P, Marcon F, Crebelli R, 1996a. Analysis of chromosome segregation by means of fluorescence in situ hybridization: application to cytokinesis-blocked human lymphocytes. Mutat Res 372: 211-219.
127. Zijno A, Leopardi P, Marcon F, Crebelli R, 1996b. Sex chromosome loss and non-disjunction in women: analysis of chromosomal segregation in binucleated lymphocytes. Chromosoma 104: 461-467.
128. Zlotorynski E, Rahat A, Skaug J, Ben-Porat N, Ozeri E, Hershberg R et al. 2003. Molecular basis for expression of common and rare fragile sites. Mol Cell Biol 23: 7143-7151.