The genetics of aging

Current Opinion in Genetics and Development

Volumn 12, Issue 3, 2002, Pages 362-369

  Perls, Thomas ^a   Kunkel, Louis ^b   Puca, Annibale ^c  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CHROMOSOME 4; DISEASE ASSOCIATION; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LIFESPAN; LONGEVITY; MAMMAL; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; PEDIGREE;

MAMMALIA;

AGING; ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGEVITY; PEDIGREE; POLYMORPHISM, GENETIC;

EID: 0036591671     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00310-6     Document Type: Review

References (52)

1. The end of world population growth
2. Demography. Prospects for human longevity
3. Centenarians: The older you get, the healthier you've been
4. Cohen: Genetic associations with human longevity at the APOE and ACE loci
5. Identifying families with likely genetic protective factors against Alzheimer disease
6. Life-long sustained mortality advantage of siblings of centenarians
7. Linkage strategies for genetically complex traits. II. The power of affected relative pairs
8. Familial excess longevity in Utah genealogies
9. Inheritance of human longevity in Iceland
10. Exceptional familial clustering for extreme longevity in humans
11. Longevity is moderately heritable in a sample of Danish twins born 1870-1880
12. Genetics of aging
13. Heritability of life span in the Old Order Amish
14. Structure and function of telomeres
15. Potential misinterpretations using models of accelerated aging
16. P53 mutant mice that display early ageing-associated phenotypes
17. Negative control of p53 by Sir-2 alpha promotes cell survival under stress
18. Cancer-stalling system accelerates aging
19. Positional cloning of the Werner's syndrome gene
20. The Werner syndrome protein is a DNA helicase
21. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
22. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
23. Molecular mechanisms of yeast longevity
24. Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
25. Aging and resistance to oxidative damage in Caenorhabditis elegans
26. Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
27. Determination of life-span in Caenorhabditis elegans by four clock genes
28. Signals from the reproductive system regulate the lifespan of C. elegans
29. C. elegans mutant that lives twice as long as wild type
30. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
31. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
32. HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
33. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
34. Requirement of NAD and sir2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
35. Extended life-span and stress resistance in the Drosophila mutant methuselah
36. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
37. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice
38. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
39. A cytosolic catalase is needed to extend adult lifespan in C. elegans
40. The p66shc adaptor protein controls oxidative stress response and life span in mammals
41. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila
42. A putative gene causes variability in lifespan among genotypically identical mice
43. Genetic epidemiologic studies on age-specified traits
44. Causes, effects, and constraints in the genetics of human longevity
45. Rapid accumulation of genome rearrangements in liver but not in brain of old mice
46. Gene expression profile of aging and its retardation by caloric restriction
47. What does cell death have to do with aging?
48. Genetic analysis of ageing: Role of oxidative damage and environmental stresses
49. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
50. Gene expression profile of aging and its retardation by caloric restriction