Age-related changes of human bone marrow: A histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages

Mechanisms of Ageing and Development

Volumn 117, Issue 1-3, 2000, Pages 57-68

  Ogawa, Takafumi ^a   Kitagawa, Masanobu ^a   Hirokawa, Katsuiku ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Aging; Apoptosis; Bone marrow; Immunohistology; Microenvironment

Indexed keywords

KI 67 ANTIGEN;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGING; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL ACTIVITY; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; HEMATOLOGIC DISEASE; HISTOMETRY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOLOGY; INFANT; MACROPHAGE; NEWBORN; NICK END LABELING; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE;

EID: 0034663420     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00137-8     Document Type: Article

References (26)

1. S. Arkins N. Rebeiz A. Biragyn D.L. Reese K.W. Kelley Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts Endocrinology 133 1993 2334 2343
2. F.J. Bot P. Shipper L. Broeders R. Delwel K. Kaushansky B. Loewenberg Interleukin-1a also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells Blood 76 1990 307 311
3. G.S. Chatta R.G. Andrews E. Rodger M. Schrag W.P. Hammond D.C. Dale Hematopoietic progenitors and aging: alterations in granulocytic precursors and responsiveness to recombinant human G-CSF, GM-CSF, and IL3 J. Gerontol. 48 1993 207 212
4. R.P. Custer F.E. Ahlfeldt Studies on structure and function of bone marrow. II. Variations in cellularity in various bones with advancing years of life and their relative response to stimuli J. Lab. Clin. Med. 17 1932 960 962
5. G. de Haan W. Nijhof G. Van Zant Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity Blood 89 1997 1543 1550
6. R.J. Hartsock E.B. Smith C.S. Patty Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the anterior iliac crest Am. J. Clin. Pathol. 43 1965 326 331
7. K. Hirokawa S. Kubo M. Utsuyama C. Kurashima T. Sado Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic cells in mice Cell. Immunol. 100 1986 443 451
8. + B cell precursors from bone marrow decreases in aging mice Cell. Immunol. 147 1993 267 278
9. K.W. Kelley S. Arkins C. Minshall Q. Liu R. Dantzer Growth hormone, growth factors and hematopoiesis Horm. Res. 45 1996 38 45
10. M. Kitagawa R. Kamiyama T. Kasuga Increase in number of bone marrow macrophages in patients with myelodysplastic syndromes Eur. J. Haematol. 51 1993 56 58
11. M. Kitagawa I. Saito T. Kuwata S. Yoshida S. Yamaguchi M. Takahashi T. Tanizawa R. Kamiyama K. Hirokawa Overexpression of tumor necrosis factor (TNF)-α and interferon (IFN)-γ by bone marrow cells from patients with myelodysplastic syndromes Leukemia 11 1997 2049 2054
12. M. Kitagawa S. Yamaguchi M. Takahashi T. Tanizawa K. Hirokawa R. Kamiyama Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia Leukemia 12 1998 486 492
13. M. Kitagawa M. Takahashi S. Yamaguchi M. Inoue S. Ogawa K. Hirokawa R. Kamiyama Expression of inducible nitric oxide synthase (NOS) in bone marrow cells of myelodysplastic syndromes Leukemia 13 1999 699 703
14. Y.-Y. Kong U. Feige I. Sarosi B. Balon A. Tafuri S. Morony C. Capparelli J. Li R. Elliott S. McCabe T. Wong G. Campagnulo E. Moran E.R. Bogoch G. Van L.T. Nguyen P.S. Ohashi D.L. Lacey E. Fish W.J. Boyle J.M. Penninger Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand Nature 402 1999 304 309
15. D.A. Lipschitz K.B. Udupa K.Y. Milton C.O. Thompson Effect of age on hematopoiesis in man Blood 63 1984 502 509
16. D. Metcalf The molecular biology and functions of the granulocyte-macrophage colony-stimulating factor Blood 67 1986 257 267
17. C. Minshall S. Arkins J. Straza J. Conners R. Dantzer G.G. Freund K.W. Kelley IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors J. Immunol. 159 1997 1225 1232
18. F. Offner T. Kerre M. De Smedt J. Plum Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy Br. J. Haematol. 104 1999 801 808
19. M. Ogawa S. Nishikawa K. Ikuta F. Yamamura M. Naito K. Takahashi S. Nishikawa B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac EMBO J. 7 1988 1337 1343
20. E.M. Rego A.B. Garcia S.R. Viana R.P. Falcao Age-related changes of lymphocytes subsets in normal bone marrow biopsies Cytometry 15 1998 22 29
21. Y. Sadahira H. Wada T. Manabe Y. Yawata Immunohistological assessment of human bone marrow macrophages in hematologic disorders Pathol. Int. 49 1999 626 632
22. J.L. Slack J. Nemunaitis D.F. Andrews J.W. Singer Regulation of cytokine and growth factor gene expression in human bone marrow stromal cells transformed with simian virus 40 Blood 75 1990 2319 2327
23. K. Suzuki K. Hirokawa S. Hatakeyama Age-related change of distribution of immunoglobulin containing cells in human bone marrow and its deviation in patients with benign gammopathy and multiple myeloma Virchows Arch. A. 404 1984 243 251
24. M.L. Tyan Age-related decrease in mouse T cell progenitors J. Immunol. 118 1977 846 851
25. + T cell subsets in the human peripheral blood Mech. Age. Dev. 63 1991 57 68
26. L.H. Williams K.B. Udupa D.A. Lipschitz Evaluation of the effect of age on hematopoiesis in the C57BL/6 mouse Exp. Hematol. 14 1986 827 832