Ageing: Definitions, mechanisms and the magnitude of the problem

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 15, Issue 6, 2001, Pages 835-849

  Balcombe, Nicholas R ^a   Sinclair, Alan ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Ageing; Definitions of ageing; Old age; Theories of ageing

Indexed keywords

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR; CALORIC RESTRICTION; CELL TRANSFORMATION; CHILD DEVELOPMENT; CHILD GROWTH; CONCEPTION; CROSS LINKING; DEATH; DEMOGRAPHY; GENETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; MEDICAL RESEARCH; MOLECULAR DYNAMICS; MORPHOLOGY; MOUSE; NEUROENDOCRINOLOGY; NONHUMAN; POPULATION RESEARCH; REPRODUCTION; SOCIAL ASPECT; THEORY; TIME;

EID: 0035700457     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2001.0244     Document Type: Article

References (76)

1. On the nature and function expressive of the law of human mortality and on a new mode of determining life contingencies
2. Motivation reconsidered: The concept of competence
3. Ageing, natural death and the compression of morbidity
4. Using Healthy Active Life Expectancy to measure population outcomes
5. Human ageing: Usual and successful
6. Heterochromic transplantation in the study of ageing
7. Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress
8. The serial cultivation of human diploid cell strains
9. Replicative lifespan of cultivated human cells: Effects of donor's age, tissue and genotype
10. Evidence for a relationship between longevity of mammalian species and lifespans of normal fibroblasts in vitro and erythrocytes in vivo
11. Genetic effects on the longevity of cultured human fibroblasts. I. Werner's syndrome
12. Lipofuscin
13. On the histochemistry and ultrastructure of age-pigment
14. Cellular ageing: Postreplicative cells. A review
15. Lipoprotein pigments; their relationship to ageing in the human nervous system. I. The lipofusicn content of nerve cells
16. The relationship between ageing and cancer: Somatic mutations or breakdown of host defence mechanisms
17. Macromolecular aspects of ageing
18. Lack of increase in DNA cross-linking in Drosophila melanogaster with age
19. Temporal changes in collagen-ageing or essential maturation
20. Ageing of the collagen fibre
21. Diffusion coefficient of various solutes for human aortic tissue with special reference to variation in tissue permeability with age
22. Pharmacolongevity; control of ageing by drugs
23. Long term lathyrogen administration to rats with special reference to ageing
24. Potassium changes with age
25. Aspects of senescent lens and retina
26. Ageing and the immune response
27. An immunological approach to ageing
28. Reactivation of immunocompetence in spleen cells of aged mice
29. The experimental manipulation of ageing by diet
30. Retarded growth, lifespan, ultimate body size and age changes in the albino rat after feeding diets restricted in calories
31. Food, reproduction and longevity: Is extended lifespan of calorie restricted animals an evolutionary adaption
32. Gorging and plasma HDL-cholesterol - The Ramadan model
33. Impact of Westernization on the nutrients of Japanese: Changes in physique, cancer, longevity and centenarians
34. The calorically restricted low-fat nutrient dense diet in Biosphere2 significantly lowers blood glucose, total leucocyte count, cholesterol and blood pressure in humans
35. Biological Mechanisms of Ageing
36. Endocrine mechanisms and ageing
37. Cellular pacemakers of ageing in mammals
38. Long-term longtitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
39. Cancer prevention with dehydroepiandrosterone and non-androgenic structural analogues
40. Adrenal androgens, insulin resistance and cardiovascular disease
41. Neuronal actions of dehydroepiandrosterone: Possible roles in brain development, ageing, memory and affect
42. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age
43. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men
44. A model for ageing
45. The biology of ageing
46. General biology of senescence
47. Individual differences in constitution and genetic background
48. Genetic control of programmed cell death in the nematode Coenorhabditis elegans
49. Positional cloning of the Werner's syndrome gene
50. Pleiotropy, natural selection and the evolution of senescence
51. Is ageing as complex as it would appear? New perspectives in ageing research
52. Repetition of molecular-genetic information as a possible factor in evolutionary changes of lifespan
53. Redundancy of information content in the genome of mammalian species as a protective mechanism determining ageing rate
54. On the nature of the ageing process
55. The modification by X-irradiation of the lifespan of haploids and diploids of the wasp Habrobracon sp
56. Predictions of the somatic mutation and mortilization theories of cellular ageing are contrary to experimental observations
57. The longevity of diploid and polyploid human fibroblasts: Evidence against the somatic mutation theory of cellular ageing
58. Genetic factors in ageing
59. Induction of ageing by radiation
60. The effects of radiation on the longevity of female Drosophilia subobscura
61. Correlation between deoxy-ribonucleic acid excision and repair and lifespan in a number of mammalian species
62. The maintenance of the accuracy of protein synthesis and its relevance to ageing
63. Ageing: A theory based on free radical and radiation chemistry
64. Superoxide dismutase: Correlation with lifespan and specific metabolic rate in primate species
65. Carotenoids and retinol: Their possible importance in determining longevity of primate species
66. Telomeres shorten during aging of human fibroblasts