DNA damage and cell cycle checkpoints

FASEB Journal

Volumn 10, Issue 2, 1996, Pages 238-247

  Kaufmann, William K ^a   Paules, Richard S ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

carcinogenesis; cyclin dependent kinase; DNA repair; DNA replication; mitosis; mutation

Indexed keywords

CYCLINE; DNA POLYMERASE; PROTEIN P53;

CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL GROWTH; CELL TRANSFORMATION; CHROMOSOME ABERRATION; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; GENE MUTATION; GENOME; MITOSIS; PRIORITY JOURNAL; REPLICON; REVIEW;

EID: 0029875247     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.2.8641557     Document Type: Review

References (44)

1. Friedberg, E. C., Walker, G. C., and Siede, W. (1995) DNA Repair and Mutagenesis, ASM Press, Washington, D.C.
2. Grisham, J. W., Kaufmann, W. K., and Kaufman, D. G. (1983) The cell cycle and chemical careinogenesis. Surv. Synth. Pathol. Res. 9-66
3. Hanawalt, P. C. (1994) Transcription-coupled repair and human disease. Science 266, 1957-1958
4. Wang, J. C. (1985) DNA topoisomerases. Annu. Rev. Biochem. 54, 665-697
5. Modrich, P. (1994) Mismatch repair, genetic stability, and cancer. Science 266, 1959-1960
6. Harley, C. B., Kirn, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., Wright, W. L., and Shay, J. W. (1994) Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59, 307-315
7. Miller, E. C. (1978) Some current perspectives on chemical carcinogenesis in humans and experimental animals. Cancer Res. 38, 1479-1496
8. Sirover, M. A., and Loeh, L. A. (1976) Infidelity of DNA synthesis in vitro, screening for potental metal mutagens or carcinogens. Science 194, 1434-1436
9. Waga, S., and Stillman, B. (1994) Anatomy of a DNA replication fork revealed by constitution of SV40 DNA replication in vitro. Nature (London) 369, 207-212
10. Sancar, A. (1994) Mechanisms of DNA excision repair. Science 266, 1954-1956
11. Kaufmann, W. K., and Wilson, S. J. (1990) DNA repair endonuclease activity during synchronous proliferation of diploid human fibroblasts. Mutat, Res. 236, 107-117
12. Kaufmann, W. K. (1989) Pathways of human cell post-replication repair. Carcinogenesis 10, 1-11
13. Boyer, J. C., Kaufmann, W. K., and Cordeiro-Stone, M. (1991) Role of postreplication repair in transformation of human fibroblasts to anchorage independence. Cancer Res. 51, 2960-2964
14. Blunt, T., Finnie, N. J., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A., and Jackson, S. P. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823
15. Phillips, J. W., and Morgan, W. F. (1994) Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome. Mol. Cell. Biol. 14, 5794-5803
16. Hartwell, L. H., and Kastan, M.B. (1994) Cell cycle control and cancer. Science 266, 1821-1828
17. Nelson, W. G., and Kastan, M. B. (1994) DNA strand breaks, the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14, 1815-1823
18. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. (1991) Participation of p53 protein in the cellular responses to DNA damage. Cancer Res. 51, 6304-6311
19. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. (1994) Mutations in the p53 tumor suppressor gene, clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4862
20. 1 arrest. Cell 76, 1013-1023
21. 1 arrest and apoptosis. Cancer Res. 54, 1169-1174
22. Kaufmann, W. K. (1995) Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metastasis Rev. 14, 31-41
23. McKinnon, P. J. (1987) Ataxia-telangiectasia, an inherited disorder of ionizing-radiation sensitivity in man. Human Genet. 75, 197-208
24. 1 cell cycle checkpoint pathway and ataxiatelangiectasia. Cancer Res. 54, 5054-5058
25. Ejima, Y., and Sasaki, M. S. (1986) Enhanced expression of X-ray- and UV-induced chromosome aberrations by cytosine arabinoside in ataxia telangiectasia cells. Mutat. Res. 159, 117-123
26. Painter, R. B. (1985) Inhibition and recovery of DNA synthesis in human cells after exposure to ultraviolet light. Mutat. Res. 145, 63-69
27. Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. L., and Smith, J. R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression system. Exp. Cell Res. 211, 90-98
28. 1 cyclins in senescent human diploid fibroblasts. accumulation of inactive cyclin D1/Cdk2 and cyclin E/Cdk2 complexes. Proc. Natl. Acad. Sci. USA 90, 11034-11038
29. DiLeonardo, A., Linke, S. P., Clarkin, K., and Wahl, G. M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cipl in normal human fibroblasts. Genes & Deu. 8, 2540-2551
30. Li, R., Waga, S., Hannon, G. J., Beach, D., and Stillman, B. (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (London) 371, 534-537
31. Watanabe, M., Maher, V. M., and McCormick, J. J. (1985) Excision repair of UV- or benzo[a]pyrene diol epoxide-induced lesions in xeroderma pigmentosum is "error-free." Mutat. Res. 146, 285-294
32. Gautschi, J. R., Kern, R. M., and Painter, R. B. (1973) Modification of replicon operation in HeLa cells by 2,4-dinitrophenol. J. Mol Biol. 80, 393-403
33. Dasso, M., and Newport, J. W. (1990) Completion of DNA replication is monitored by a feedback system that contiols the initiation of mitosis in vitro, studies in Xenopus. Cell 61, 811-823
34. Navas, T. A., Zhou, Z., and Elledge, S. J. (1995) DNA polymerase links the DNA replication machinery to the S phase checkpoint. Cell 80, 29-39
35. Sasaki, M. S., and Taylor, A. M. R. (1994) Dissociation between radioresistant DNA replication and chromosomal radiosensitivity in ataxia telangiectasia cells. Mutat. Res. 307, 107-113
36. 2 checkpoint function in cells from individuals with familial cancer syndomes. Cancer Res. 55, 1763-1773
37. Scott, D., Spreadborough, A. R., and Roberts, S. A. (1994) Radiation-induced G(2) delay and spontaneous chromosome aberrations in ataxia-telangiectasia homozygotes and heterozygotes. Int. J. Radiat. Biol. 66 (Suppl. 6) 157-163.
38. Olivieri, G., and Micheli, A. (1983) Mitotic delay and repair in human lymphocytes. Mutat. Res. 122, 65-72
39. 2 arrest in Chinese hamster ovary cells. Cancer Res. 50, 3761-3766
40. cdc2, the S and M kinase? New Biologist 2, 389-401
41. Reed, S. I. (1992) Cyclin-dependent protein kinases. Annu. Rev. Cell Biol. 8, 529-561
42. 2 arrest induced by nitrogen mustard. Proc. Natl. Acad. Sci. USA 91, 9480-9484
43. Steinmann, K. E., Pei, X. F., Stopler, H., Schlegel, R., and Schlegel, R. (1994) Elevated expression and activity of mitolic regulatory proeins in human papillomavirus-immortalized keratinocytes. Oncogens 9, 387-394
44. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Taylor, A. M. R., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753