Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes

Cancer Epidemiology Biomarkers and Prevention

Volumn 6, Issue 4, 1997, Pages 249-256

  Bolognesi, Claudia ^a   Abbondandolo, Angelo ^a   Barale, Roberta ^b   Casalone, Rosario ^c   Dalprà, Leda ^d   De Ferrari, Marcella ^a   Degrassi, Francesca ^e   Forni, Alessandra ^d   Lamberti, Laura ^f   Lando, Cecilia ^a   Migliore, Lucia ^b   Padovani, Paola ^a   Pasquini, Rossana ^a   Puntoni, Riccardo ^g   Sbrana, Isabella ^b   Stella, Mario ^h   Bonassi, Stefano ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c OSPEDALE DI CIRCOLO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF TURIN   (Italy)

^g UNIVERSITY OF PERUGIA   (Italy)

^h Servizio di Genetica Umana   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE; ARTICLE; BIOLOGICAL MONITORING; CHILD; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CYTOGENETICS; HUMAN; LYMPHOCYTE; MICRONUCLEUS; NORMAL HUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; DNA DAMAGE; ENVIRONMENTAL MONITORING; FEMALE; GENE FREQUENCY; HUMANS; INFANT; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED; SISTER CHROMATID EXCHANGE;

EID: 16944363732     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Bonassi, S., Bolognesi, C., Abbondandolo, A., Barale, R., Bigatti, P., Camurri, L., Dalpra', L., De Ferrari, M., Fomi, A., Lando, C., Padovani, P., Pasquini, R., Stella, M., and Puntoni, R. Influence of sex on cytogenetic end points: evidence from a large human sample and review of the literature. Cancer Epidemiol., Biomarkers & Prev., 4: 671-679, 1995.
2. Kutlaca, R., Seshadri, R., and Morley, A. A. Effect of age on sensitivity of human lymphocytes to radiation: a brief note. Mech. Ageing Dev., 19: 97-101, 1982.
3. Martin, G. M. Genetic and environmental modulations of chromosomal stability: their roles in aging and oncogenesis. Ann. NY Acad. Sci., 621: 401-417, 1991.
4. Simic, M. G. The rate of DNA damage and aging. In: I. Emerit and B. Chance (eds.), Free Radicals and Aging, pp 20-30. Basel: Birkhauser Verlag, 1992.
5. Bohr, V. DNA repair fine structure and its relations to genomic instability. Carcinogenesis (Lond.), 16: 2885-2892, 1995.
6. Hanawalt, P. C., Gee, P., Ho, L., Hsu, R. K., and Kane, C. J. M. Genomic heterogeneity of DNA repair: role in aging? Ann. NY Acad. Sci., 663: 17-25, 1992.
7. 32P-postlabeling: relationships to cancer and aging. Exp. Gerontol., 27: 533-549, 1992.
8. Pacifici, R. E., and Davies, K. J. A. Protein, lipid and DNA repair systems in oxidative stress: the free radical theory of aging revisited. Gerontology, 37: 166-180, 1991.
9. Ames, B. N., and Shigenaga, M. K. Oxidants are a major contributor to aging. Ann. NY Acad. Sci., 663: 85-96, 1992.
10. Crawford, J., and Cohen, H. J. Relationship of cancer and aging. Clin. Geriatr. Med., 3: 419-432, 1987.
11. Ames, B. N., and Gold, L. S. Endogenous mutagens and the causes of aging and cancer. Mutat. Res., 250: 3-16, 1991.
12. Bill, C. A., Grochan, B. M., Meyn, R. E., Bohr, V. A., and Tofilon, P. J. Loss of intragenomic DNA repair heterogeneity with cellular differentiation. J. Biol. Chem., 266: 21821-21826, 1991.
13. Wei, Q., Matanoski, G. M., Farmer, E. R., Hedayat, M. A., and Grossman, L. DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc. Natl. Acad. Sci. USA, 90: 1614-1618, 1993.
14. Kruk, P. A., Rampino, N., and Bohr, V. A. DNA damage and repair in telomeres: relation to aging. Proc. Natl. Acad. Sci. USA, 92: 258-262, 1995.
15. Jacobs, P. A., Court-Brown, W. M., and Doll, R. Distribution of human chromosome counts in relation to age. Nature (Lond.), 191: 1178-1180, 1961.
16. Fitzgerald, P. H., Pickering, A. F., Mercer, J. M., and Miethke, P. M. Premature centromere division: a mechanism of non-disjunction causing X chromosome aneuploidy in somatic cells of man. Ann. Hum. Genet., 38: 417-428, 1975.
17. Fitzgerald, P. H., and McEwan, M. Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women. Hum. Genet., 39: 329-337, 1977.