Genetic stability; The key to longevity?

Medical Hypotheses

Volumn 53, Issue 4, 1999, Pages 329-332

  Davidovic M ^a  

^a Center of Geriatric Medicine   (Yugoslavia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGING; CANCER; CHROMOSOME ABERRATION; DNA DAMAGE; DNA REPAIR; EVOLUTION; GENETIC STABILITY; GERONTOLOGY; HEART DISEASE; HUMAN; IMMUNE SYSTEM; LIFESPAN; LONGEVITY; METABOLIC RATE; PRIMATE; PRIORITY JOURNAL; SENESCENCE; SHORT SURVEY; THEORY;

PRIMATES;

EID: 0032737373     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1998.0767     Document Type: Article

References (40)

1. ZS-Nagy I., Cutler R., Semsei I. Dysdifferentiation hypothesis of aging and cancer: a comparison with the membrane hypothesis of aging. Ann NY Acad Sci. 521:1988;215-225.
2. Newton R., Ducore J. M., Sohal R. S. Relation between life expectancy and endogenous DNA single-strand breakage, strand break induction and DNA repair capacity in the adult house?y, musca domestica. Mech Ageing Dev. 49:1989;259-270.
3. Vijg J., Mullaart E., Lohman P. H. M. UV-induced unsheduled DNA synthesis in ?broblasts of aging inbred rats. Mut Res. 146:1985;197-204.
4. Dutkovski R. T., Lech R., Saiano-Coico L. Increased chromosomal instability in lymphocytes from elderly humans. Mut Res. 1985;149(3) 505-512.
5. Mukfeerjeea A. B., Weinstein M. E. Sequence of centromere separation of mitotic chromosome during human cellular aging. Mech Ageing Dev. 45:1988;56-64.
6. Esposito D. Chromosome of older humans are more prone to aminopterin-induced breakage. Proc Natl Acad Sci USA. 86:1989;1302-1306.
7. Wen W. N. The effect of age and cell proliferation on the frequency of sister chromatid exchange in human lymphocytes cultured in vitro. Mech Ageing Dev. 21:1983;377-384.
8. Gaubatz J. W. Postlabeling analysis of indigenous aromatic DNA adducts in mouse myocardium during aging. Arch Geront Geriatr. 8:1989;47-54.
9. Kishi K., Homma A., Kawa A. Age related changes in the frequency of ARA-C induced chromosome aberrations in human peripheral blood lymphocytes. Mech Ageing Dev. 37:1987;211-219.
10. Matsuyama S. C., Cohen D., Jarvik L. F. Hypodiploidy and serum immunoglobulin concentration in the elderly. Mech Ageing Dev. 8:1978;407-412.
11. Makinodan T., Lubinski J., Fong T. Cellular, biochemical and molecular basis of T-cell senescence. Arch Pathol Lab Med. 111:1987;910-914.
12. Sargens E. V., Burns F. J. Repair of radiation-induced DNA damage in rat epidermis as a function of age. Radiat Res. 102:1985;176-181.
13. Zahn R. K., Reinmuller J., Beyer R. Age correlated DNA damage in human muscle tissue. Mech Ageing Dev. 41:1987;73-117.
14. Honda S., Matsuo M. Lack of recovery from oxygen-induced damage to colony formation and DNA synthesis in senescent human diploid fibroblast. Mech Ageing Dev. 40:1987;81-87.
15. Davidović M. Chromosome changes in old age. Age Vault. 1995;Eds S. Formosa, Inia, Malta. p. 235-241.
16. Moorhead P. S., Nowell P. G., Mellman W. J., Battips D. M., Hungerford D. A. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 20:1960;613-616.
17. Perry P. E., Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature. 251:1974;156-158.
18. Savage J. R. K. Classification and relationship of induced chromosomal structural changes. J Med Genet. 12:1975;103-122.
19. Lighart G. J., Corberaud C., Founrier P. Admission criteria for immunogerontological studies in man: the senior protocol. Mech Ageing Dev. 28:1984;47-56.
20. Marthens F., AlAchkar W., Aurias A. The rate of chromosome breakage is age dependent in lymphocytes of adult controls. Hum Genet. 73:1986;290-297.
21. Ono T., Shinya K., Uehara Y. Endogenous virus genome become hypometilater tissue - specifically during aging process of C&B1 mice. Mech Ageing Dev. 50:1989;27-36.
22. Lipman J. M., Turturro A., Hart R. W. The influence of dietary restriction on DNA repair in rodents: a preliminary study. Mech Ageing Dev. 48:1989;135-143.
23. Mullart E., Roza L., Lohman P. H. M. The removal of UV-induced pyrimidine dimmers from DNA rat skin cells in vitro and in vivo in relation to aging. Mech Ageing Dev. 47:1989;253-264.
24. Ono T., Uehara T., Kurishita A. Biological significance of DNA in the ageing process. Age and Ageing. 22:1993;S34-43.
25. Vijg J. Studies on DNArepair defects in degenerative brain disease. Age Ageing. 22:1993;S44-52.
26. Melaragno M. I. Lymphocyte proliferation and sister chromatid exchange in Alzheimer's disease. Gerontology. 37:1991;293.
27. Hayflick L. Theories of biological aging. Exp Geront. 20:1985;145-159.
28. Hayflick L. Why do we live so long. Geriatrics. 10:1988;77-87.
29. Hollis W. S. The aged thyroid gland. Geriatrics. 23:1968;124-131.
30. Korolija, P. The secretion of gastric juice in the aged persons, 1979.
31. Hallgren H. M. Immune response alterations during human aging. J Med Techn. 2:1985;685-689.
32. Nagel J. A., Chrest F. J., Adeler W. H. Enumeration of T-lymphocytes induced by monoclonal antibodies in young and aged humans. J Immunol. 127:1981;2086.
33. Niwa Y., Kasama T., Miyachi Y. Neutrophil chemotaxis phagocytosis and parameters of reactive oxygen species in human aging: gross - sectional and longitudinal studies. Life Sci. 44:1989;1655-1664.
34. Crawford J., Cohen H. J. Aging and neoplasia. Eisdorfer C. Annual Review of Gerontology and Geriatrics. 1984;3-32 Springer, New York.
35. Piantanelli L. Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality. Ann NY Acad Sci. 521:1988;99-109.
36. Capurso, A. Resta, F. Colcacicco, A. M. High level of serum Lp and low level of LDL-cholesterol in centenarians.
37. Pula, B. Manaresi, M. L. Baldelli, M. V. Salvioli, G. I. Mortality rate decreases in the very old.
38. Bulpitt C. J., Fletcher A. E., Amery A. The hypertension in the very elderly trial (HYVET). J Hum Hyp. 8:1994;631-632.
39. Stevićc, R. Mitićc, S. Davidovićc, M. Milošsevićc, D. Mrdja, J. Perićc, G. Pancreatic glucoregulation hormone and age: importance of glucagon. Third Congress of the International Association of Gerontology, European Region, 1996, 33.
40. Agundez J. A., Rodriguez I., Olivera M. CYP2D6, NAT2 and CYP2E1 genetic polymorphism in nonagenarians. Ageing. 26:1997;147-151.