Functional decline in aging and disease: A role for apoptosis

Journal of the American Geriatrics Society

Volumn 49, Issue 9, 2001, Pages 1234-1240

  Joaquin, Arnel M ^a   Gollapudi, Sastry ^a,b  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Apoptosis; Functional decline

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTIDIABETIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIOVASCULAR AGENT; CASPASE; CASPASE 3; CASPASE 8; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLARITHROMYCIN; CYTOCHROME C; ENALAPRIL; ERYTHROMYCIN; GLUCOCORTICOID; HEAT SHOCK PROTEIN 72; MACROLIDE; NERVE GROWTH FACTOR RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; SULFONYLUREA DERIVATIVE; TELOMERASE; THEOPHYLLINE; THIAZIDE DIURETIC AGENT; TOLBUTAMIDE; TUMOR NECROSIS FACTOR RECEPTOR;

AGED; AGING; APOPTOSIS; ARTICLE; ASTHMA; AUTOIMMUNE DISEASE; CANCER; CANCER PREVENTION; CARDIOVASCULAR DISEASE; COLORECTAL CANCER; DEGENERATIVE DISEASE; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; MITOCHONDRIAL MEMBRANE; NEUROLOGIC DISEASE; RESPIRATORY TRACT INFECTION;

AGED; AGING; APOPTOSIS; CASPASES; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 0034802113     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2001.04990.x     Document Type: Article

References (90)

1. Apoptosis in human disease: A new skin for the old ceremony?
2. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
3. Apoptosis: Mechanisms and roles in pathology
4. Human ICE/CED-3 protease nomenclature
5. Caspases: The executioners of apoptosis
6. Biochemical pathways of caspase activation during apoptosis
7. Identification of caspases and apoptosis in the simple metazoan Hydra
8. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
9. Caspases: Enemies within
10. Two CD95 (APO-l/Fas) signaling pathways
11. Fas and Fas ligand: A death factor and its receptor
12. Death receptors: Signaling and modulation
13. A novel domain within the 55Kd TNF receptor signals cell death
14. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
15. An induced proximity model for caspase-8 activation
16. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
17. Mitochondria and apoptosis
18. The mitochondrion: Is it central to apoptosis?
19. The biochemistry of apoptosis
20. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
21. The Bcl-2 family of proteins: Regulators of cell death and survival
22. The Bcl-2 protein family: Arbiters of cell survival
23. Cell death inhibition: Keeping caspases in check
24. The IAP family: Endogenous caspase inhibitors with multiple biological activities
25. X-linked IAP is a direct inhibitor of cell-death proteases
26. Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway
27. Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging
28. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability
29. Telomere shortening in kidneys with age
30. Aging enhances the activation of the permeability transition pore in mitochondria
31. For debate: Defective mitochondria, free radicals, cell death, aging-reality or myth-ochondria?
32. Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: Age-associated differences
33. Age-related hippocampal changes in Bcl-2: Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: Increased susceptibility with aging
34. Expression of Fas and Bcl-2 in lymphocyte subsets of aging African American population
35. Aging as an intracellular process
36. Chondrocyte apoptosis in development, aging and disease
37. Biological aging and apoptosis - Mechanism in cardiovascular disease?
38. Lymphocytes as cell model to study apoptosis in Alzheimer's disease: Vulnerability to programmed cell death appears to be altered
39. Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls
40. Myocardial apoptosis in the overloaded and the aging heart: A critical role of mitochondria?
41. Evidence of apoptosis in human carotid atheroma
42. Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance
43. Life, death and kidneys: Regulation of renal programmed cell death
44. Recent advances on neuronal caspases in development and neurodegeneration
45. Apoptosis: A role in skin aging?
46. Apoptosis and the nervous system
47. Cardiomyopathy of the aging human heart: Myocyte loss and reactive cellular hypertrophy
48. Apoptosis in myocytes in end-stage heart failure
49. Apoptosis in failing human heart
50. Cellular apoptosis and proliferation in experimental renal fibrosis
51. Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes
52. Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation
53. Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic aging
54. Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: Changes in TNF-alpha receptor expression and activation of caspases
55. Cell proliferation and apoptosis in the immune system in the elderly
56. Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans
57. Apoptosis in the pathogenesis and treatment of disease
58. Prevention of apoptosis reperfusion renal injury by calcium channel blockers
59. Estrogen and NGF synergistically protect terminally differentiated, ERalpha-transfected PC12 cells from apoptosis
60. Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells
61. Biomolecular changes in the aging myocardium: The effect of enalapril
62. Aspirin induced apoptosis in gastric cancer cells
63. Induction of apoptosis by salicylates in B-cell chronic lymphocytic leukemia
64. Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells
65. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats
66. Apoptosis in vasculature of spontaneously hypertensive rats: Effect of an angiotensin converting enzyme inhibitor and a calcium channel antagonist
67. Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure
68. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis
69. Nifedipine induces apoptosis in cultured vascular smooth muscle cells from spontaneously hypertensive rats
70. Cardiovascular remodeling, apoptosis, and drugs
71. Nifedipine does not induce but rather prevents apoptosis in cardiomyocytes
72. Effects of calcium channel blockers on cellular apoptosis: Implications for carcinogenic potential
73. Prevention of apoptosis reperfusion renal injury by calcium channel blockers
74. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration
75. The cellular and physiologic effects of beta blockers in heart failure
76. Novel mechanisms in the treatment of heart failure: Inhibition of oxygen radicals and apoptosis by carvedilol
77. Mitochondrial activity after cold preservation of pancreatic islet cells treated with pefloxacin (PFX)
78. Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells
79. Thiazide treatment of rats provokes apoptosis in distal tubule cells
80. Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL-5
81. Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma
82. Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells
83. Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins
84. Neuroprotection by a caspase inhibitor in acute bacterial meningitis
85. Gene expression profile of aging and its retardation by caloric restriction
86. Influence of short-term repeated fasting on the longevity of female (NZB × NZW)F1 mice
87. Caloric restriction and immunosenescence: A current perspective
88. Short-term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: Role of cell replication, apoptosis, and gene expression
89. Modulation of antioxidant enzymes and apoptosis in mice by dietary lipids and treadmill exercise
90. Impact of treadmill exercise on early apoptotic cells in mouse thymus and spleen