Activation of p53-mediated cell cycle checkpoint in response to micronuclei formation

Journal of Cell Science

Volumn 111, Issue 7, 1998, Pages 977-984

  Sablina, Anna A ^a   Ilyinskaya, Galina V ^a   Rubtsova, Svetlana N ^a   Agapova, Larissa S ^a   Chumakov, Peter M ^b   Kopnin, Boris P ^a  

^a Cancer Research Center   (Russian Federation)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Cell cycle checkpoint; Micronucleus; p53

Indexed keywords

BROXURIDINE; DEMECOLCINE; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CHROMOSOME SEGREGATION; EMBRYO; GENE EXPRESSION; IMMUNOFLUORESCENCE; MICRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE;

ANIMALS; CELL CYCLE; CELL LINE; CHROMOSOME BREAKAGE; DEMECOLCINE; HUMANS; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; RATS; S PHASE; TETRACYCLINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031979686     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Agapova, L. S., Ilyinskaya, G. V., Turovets, N. A., Ivanov A., Chumakov, P. M. and Kopnin, B. P. (1996). Chromosome changes caused by alterations of p53 expression. Mutat Res. 354, 129-138.
2. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Nat. Acad. Sci. USA 92, 8493-8497.
3. Brown, J. K. and Bick, Y. A. (1986). Comparison of cellular effects of phomopsin and colcemid in Chinese hamster cells in vitro. Cytobios. 46, 78-91.
4. Carder, P., Wyllie, A. H., Purdie, C. A., Morris, R. G., White S., Piris, J. and Bird, C. C. (1993). Stabilized p53 facilitates aneuploid clonal divergence in colorectal cancer. Oncogene 8, 1397-1401.
5. Chernova, O. B., Chernov, M. V., Agarwal, M. L., Taylor, W. R. and Stark, G. R. (1995). The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited. Trends Biochem. Sci. 20, 431-434.
6. Chernov, M. V. and Stark, G. R. (1997). The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate. Oncogene 14, 2503-2510
7. Cox, L. S. and Lane, D. P. (1995). Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 17, 507-508.
8. 1 arrest. Cell 76, 1013-1023.
9. El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. and Vogelstein, B. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
10. 1 arrest and apoptosis. Cancer Res. 54, 1169-1174.
11. Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S. and Vande Woude, G. F. (1996). Abnormal centrosome amplification in the absence of p53. Science 211, 1744-1747.
12. Harper, J. W., Elledge, S. J., Keyomarsi, K., Dynlacht, B., Tsai, L. H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L. and Swindell, E. (1995). Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6, 387-400.
13. Harvey, D. M. and Levine, A. J. (1991). p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasis. Genes Dev. 5, 2375-2385.
14. Hartwell, L. H. and Kastan, M. B. (1994). Cell cycle control and cancer. Science 266, 1821-1828.
15. Hennig, U. G., Rudd, N. L. and Hoar, D. I. (1988). Kinetochore immunofluorescence in micronuclei: a rapid method for the in situ detection of aneuploidy and chromosome breakage in human fibroblasts. Mutant. Res. 203, 405-414.
16. Horikoshi, N., Usheva, A., Chen, J., Levine, A. J., Weinmann, R. and Shenk, T. (1995). Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol. Cell Biol. 15, 227-234.
17. Ishizaka, Y., Chernov, M. V., Burns C. M. and Stark, G. R. (1995). p53-dependent growth arrest of REF52 cells containing newly amplified DNA. Proc. Nat. Acad. Sci. USA 92, 3224-3228.
18. Jacks, T. and Weinberg, R. A. (1996). Cell-cycle control and its watchman. Nature 381, 643-644.
19. Kelman, Z. (1997). PCNA: structure, functions and interactions. Oncogene 14, 629-640.
20. Ko, L. J. and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
21. Komarova, E. A., Chernov, M. V., Franks, R., Wang K., Armin, G., Zelnick, C. R., Chin, D. M., Bacus, S. S., Stark, G. R. and Gudkov, A. V. (1997). Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J. 6, 1391-1400.
22. Kopnin, B. P., Stromskaya, T. P., Kondratov, R. V., Ossovskaya, V. S., Pugacheva, E. N., Rybalkina, E. Y., Knochlova, O. A. and Chumakov, P. M. (1995). Influence of exogenous RAS and P53 on P-glycoprotein function in immortalized rodent fibroblasts, Oncol. Res. 7, 299-306.
23. Levine, A. J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
24. 1 restriction point fails to halt cell cycle progression. Oncogene 15, 337-345.
25. Lowe, S. W. and Ruley, H. E. (1993). Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7, 535-545.
26. Lutziker, S. G. and Levine, A. J. (1996). A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Nature Med. 2, 804-810.
27. Martinez, J., Georgoff, I. and Levine, A. J. (1991). Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev. 5, 151-159.
28. Mikhalovitz, D., Halevy, O. and Oren M. (1990). Conditional inhibition of transformation and of cell proliferation by temperature-sensitive mutant of p53. Cell 62, 671-677.
29. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D., Hoffman, A. B. and Reed, J. C. (1994a). Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9, 1799-1805.
30. Miyashita, T., Harigai, M., Hanada, M. and Reed, J. C. (1994b). Identification of a p53-dependent negative response clement in the bcl-2 gene. Cancer Res. 54, 3131-3135.
31. Miyashita, T. and Reed, J. C. (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299.
32. Nusse, M., Kramer, M., Viaggi, S., Bartsch, A. and Bonatti, S. (1987). Antikinetochore antibodies and flow karyotyping: new techniques to detect aneuploidy in mammalian cells induced by ionizing radiation and chemicals. Mol., Toxicol. 1, 393-405.
33. Onishchenko, G. E. (1978). Correlation between the number of centrioles and ploidy of mouse liver hepatocytes. Tsitologiia 20, 395-399.
34. Oren, M. and Prives, C. (1996). p53: upstream, downstream and off stream. Biochim. Biophys. Acta 1288, R13-R19.
35. Ossovskaya, V. S., Mazo, I. A., Chernov, M. V., Chernova, O. B., Strezoska, Z., Kondratov, R., Stark, G. R., Chumakov, P. M. and Gudkov, A. V. (1996). Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc. Nat. Acacl. Sci. USA 93, 10309-10314.
36. Owen-Schaub, L. B., Zhang, W., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A. B., Zhang, W. W. and Kruzel, E. (1995). Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell Biol. 1555, 3032-3040.
37. Polyak, K., Waldman, T., He T. C., Kinzler, K. W. and Vogelstein, B. (1996). Genetic determinants of p53-induccd apoptosis and growth arrest. Genes Dev. 10, 1945-1952.
38. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W. and Vogelstein, B. (1997). A model for p53-induced apoptosis. Nature 389, 300-305.
39. Radley, J. M. and Scurfield, G. (1980). The mechanism of platelet release. Blood. 56, 996-949.
40. Ragimov, N., Krauskopf, A., Navot, N., Roller, V., Oren, M. and Aloni, Y. (1993). Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif. Oncogene 8, 1183-1193.
41. Seto, E., Usheva, A., Zambetti, G. P., Mumand, J., Hurikoshi, N., Weinmann, R., Levine, A. J. and Shenk, T. (1992). Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc. Nat., Acad. Sci. USA 89, 12028-12032.
42. 2/M by p53. Oncogene 10, 109-115.
43. Stopper, H., Eckert, I., Schiffmann, D., Spencer, D. L. and Caspary, W. J. (1994). Is micronucleus induction by aneugens an early event leading to mutagenesis? Mutagensis 9, 411-416.
44. Tiemann, F., Zerrahn, J. and Deppert, W. (1995). Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation. J. Virol. 69. 6115-6121.
45. Tishler, R. B., Lamppu, D. M., Park, S. and Price, B. D. (1995). Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53. Cancer Res. 55, 6021-6025.
46. Tsukada, T., Tomooka, V., Takai, S., Ueda, Y., Nishikawa, S., Yagi, T., Tokunaga, T., Takeda, N., Suda, Y., Abe, S., et al. (1993). Enhanced proliterative potential in culture of cells from p53-deficient mice. Oncogene 8, 3313-3322.
47. Zhan, Q., Lord, K. A., Alamo, J. J., Hollander, M. C., Carrier, F., Ron, D., Kohn, W. W., Huffman, B., Lieberman, D. A. and Furnace, A. J. J. (1994). The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell. Biol. 14, 2361-2371.