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Volumn 4, Issue 3, 2009, Pages 298-308

Immune-directed gene therapeutic development for alzheimer's, prion, and parkinson's diseases

Author keywords

Active vaccination; Alzheimer's disease; Parkinson's disease; Passive vaccination; Prion disease; Single chain antibody

Indexed keywords

ALPHA SYNUCLEIN; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-42]; CHEMOKINE; CHOLINESTERASE INHIBITOR; CYTOKINE; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOLOGICAL ADJUVANT; PARVOVIRUS VECTOR; PRION PROTEIN ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TETANUS TOXIN; TETANUS TOXIN FRAGMENT C; UNCLASSIFIED DRUG;

EID: 68749100991     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-008-9133-3     Document Type: Review
Times cited : (7)

References (110)
  • 1
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • BJ Bacskai ST Kajdasz ME McLellan D Games P Seubert D Schenk BT Hyman 2002 Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy J Neurosci 22 7873 7878
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    Games, D.3    Seubert, P.4    Schenk, D.5    Hyman, B.T.6
  • 3
    • 53749102630 scopus 로고    scopus 로고
    • Therapeutic strategies for Alzheimer's disease
    • DM Barten CF Albright 2008 Therapeutic strategies for Alzheimer's disease Mol Neurobiol 37 2-3 171 186
    • (2008) Mol Neurobiol , vol.37 , Issue.23 , pp. 171-186
    • Barten, D.M.1    Albright, C.F.2
  • 4
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • RT Bartus RLd Dean B Beer AS Lippa 1982 The cholinergic hypothesis of geriatric memory dysfunction Science 217 408 414
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Rld, D.2    Beer, B.3    Lippa, A.S.4
  • 6
    • 43849103202 scopus 로고    scopus 로고
    • Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons
    • KM Bishop EK Hofer A Mehta A Ramirez L Sun M Tuszynski RT Bartus 2008 Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons Exp Neurol 211 574 584
    • (2008) Exp Neurol , vol.211 , pp. 574-584
    • Bishop, K.M.1    Hofer, E.K.2    Mehta, A.3    Ramirez, A.4    Sun, L.5    Tuszynski, M.6    Bartus, R.T.7
  • 8
    • 27544470486 scopus 로고    scopus 로고
    • Snaring the function of alpha-synuclein
    • NM Bonini BI Giasson 2005 Snaring the function of alpha-synuclein Cell 123 359 361
    • (2005) Cell , vol.123 , pp. 359-361
    • Bonini, N.M.1    Giasson, B.I.2
  • 10
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • DL Brody DM Holtzman 2008 Active and passive immunotherapy for neurodegenerative disorders Annu Rev Neurosci 31 175 193
    • (2008) Annu Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 11
    • 4344566457 scopus 로고    scopus 로고
    • Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
    • C Burger OS Gorbatyuk MJ Velardo CS Peden P Williams S Zolotukhin PJ Reier RJ Mandel N Muzyczka 2004 Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system Mol Ther 10 302 317
    • (2004) Mol Ther , vol.10 , pp. 302-317
    • Burger, C.1    Gorbatyuk, O.S.2    Velardo, M.J.3    Peden, C.S.4    Williams, P.5    Zolotukhin, S.6    Reier, P.J.7    Mandel, R.J.8    Muzyczka, N.9
  • 14
    • 54749126318 scopus 로고    scopus 로고
    • Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain
    • CN Cearley LH Vandenberghe MK Parente ER Carnish JM Wilson JH Wolfe 2008 Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain Mol Ther 16 10 1710 1718
    • (2008) Mol Ther , vol.16 , Issue.10 , pp. 1710-1718
    • Cearley, C.N.1    Vandenberghe, L.H.2    Parente, M.K.3    Carnish, E.R.4    Wilson, J.M.5    Wolfe, J.H.6
  • 16
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
    • KA Conway SJ Lee JC Rochet TT Ding RE Williamson PT Lansbury Jr 2000 Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy Proc Natl Acad Sci U S A 97 571 576
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury Jr, P.T.6
  • 17
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein Adduct
    • KA Conway JC Rochet RM Bieganski PT Lansbury Jr 2001 Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein Adduct Science 294 1346 1349
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury Jr, P.T.4
  • 18
    • 34547670597 scopus 로고    scopus 로고
    • HSV-1 amplicon vectors: A promising and versatile tool for gene delivery
    • D Cuchet C Potel J Thomas AL Epstein 2007 HSV-1 amplicon vectors: a promising and versatile tool for gene delivery Expert Opin Biol Ther 7 975 995
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 975-995
    • Cuchet, D.1    Potel, C.2    Thomas, J.3    Epstein, A.L.4
  • 19
    • 34548664313 scopus 로고    scopus 로고
    • Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease
    • RB DeMattos KR Bales DJ Cummins JC Dodart SM Paul DM Holtzman 2001 Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease Proc Natl Acad Sci U S A 3 3
    • (2001) Proc Natl Acad Sci U S A , vol.3 , pp. 3
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 20
    • 38749112528 scopus 로고    scopus 로고
    • Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: Anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    • JD Ding J Lin BE Mace R Herrmann P Sullivan C Bowes Rickman 2008 Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model Vision Res 48 339 345
    • (2008) Vision Res , vol.48 , pp. 339-345
    • Ding, J.D.1    Lin, J.2    MacE, B.E.3    Herrmann, R.4    Sullivan, P.5    Bowes Rickman, C.6
  • 22
    • 20744448499 scopus 로고    scopus 로고
    • Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies
    • G Donofrio FL Heppner M Polymenidou C Musahl A Aguzzi 2005 Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies J Virol 79 8330 8338
    • (2005) J Virol , vol.79 , pp. 8330-8338
    • Donofrio, G.1    Heppner, F.L.2    Polymenidou, M.3    Musahl, C.4    Aguzzi, A.5
  • 24
    • 43449092187 scopus 로고    scopus 로고
    • Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease
    • SS El-Amouri H Zhu J Yu R Marr IM Verma MS Kindy 2008 Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease Am J Pathol 172 1342 1354
    • (2008) Am J Pathol , vol.172 , pp. 1342-1354
    • El-Amouri, S.S.1    Zhu, H.2    Yu, J.3    Marr, R.4    Verma, I.M.5    Kindy, M.S.6
  • 25
  • 26
    • 34147130637 scopus 로고    scopus 로고
    • Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity
    • S Emadi H Barkhordarian MS Wang P Schulz MR Sierks 2007 Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity J Mol Biol 368 1132 1144
    • (2007) J Mol Biol , vol.368 , pp. 1132-1144
    • Emadi, S.1    Barkhordarian, H.2    Wang, M.S.3    Schulz, P.4    Sierks, M.R.5
  • 27
    • 0035979274 scopus 로고    scopus 로고
    • Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody
    • M Enari E Flechsig C Weissmann 2001 Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody Proc Natl Acad Sci U S A 98 9295 9299
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9295-9299
    • Enari, M.1    Flechsig, E.2    Weissmann, C.3
  • 28
    • 33644917181 scopus 로고    scopus 로고
    • Immune shaping and the development of Alzheimer's disease vaccines
    • HJ Federoff WJ Bowers 2005 Immune shaping and the development of Alzheimer's disease vaccines Sci Aging Knowledge Environ 2005 46 pe35
    • (2005) Sci Aging Knowledge Environ , vol.2005 , Issue.46 , pp. 35
    • Federoff, H.J.1    Bowers, W.J.2
  • 29
    • 33749841522 scopus 로고    scopus 로고
    • The aggregation and fibrillation of alpha-synuclein
    • AL Fink 2006 The aggregation and fibrillation of alpha-synuclein Acc Chem Res 39 628 634
    • (2006) Acc Chem Res , vol.39 , pp. 628-634
    • Fink, A.L.1
  • 30
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • W Fischer K Wictorin A Bjorklund LR Williams S Varon FH Gage 1987 Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor Nature 329 65 68
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Bjorklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 31
    • 42549089024 scopus 로고    scopus 로고
    • Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4
    • ME Frazer JE Hughes MA Mastrangelo JL Tibbens HJ Federoff WJ Bowers 2008 Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4 Mol Ther 16 845 853
    • (2008) Mol Ther , vol.16 , pp. 845-853
    • Frazer, M.E.1    Hughes, J.E.2    Mastrangelo, M.A.3    Tibbens, J.L.4    Federoff, H.J.5    Bowers, W.J.6
  • 32
    • 54349127591 scopus 로고    scopus 로고
    • A DNA vaccine for multiple sclerosis
    • H Garren 2008 A DNA vaccine for multiple sclerosis Expert Opin Biol Ther 8 1539 1550
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 1539-1550
    • Garren, H.1
  • 34
    • 0029127954 scopus 로고
    • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
    • JM George H Jin WS Woods DF Clayton 1995 Characterization of a novel protein regulated during the critical period for song learning in the zebra finch Neuron 15 361 372
    • (1995) Neuron , vol.15 , pp. 361-372
    • George, J.M.1    Jin, H.2    Woods, W.S.3    Clayton, D.F.4
  • 36
    • 0035142278 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • J Grutzendler JC Morris 2001 Cholinesterase inhibitors for Alzheimer's disease Drugs 61 41 52
    • (2001) Drugs , vol.61 , pp. 41-52
    • Grutzendler, J.1    Morris, J.C.2
  • 39
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • J Hardy 1997 Amyloid, the presenilins and Alzheimer's disease Trends Neurosci 20 154 159
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 40
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • J Hardy D Allsop 1991 Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends Pharmacol Sci 12 383 388
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 41
    • 0032150877 scopus 로고    scopus 로고
    • Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau
    • J Hardy K Duff KG Hardy J Perez-Tur M Hutton 1998 Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau Nat Neurosci 1 355 358
    • (1998) Nat Neurosci , vol.1 , pp. 355-358
    • Hardy, J.1    Duff, K.2    Hardy, K.G.3    Perez-Tur, J.4    Hutton, M.5
  • 42
    • 0022486717 scopus 로고
    • Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection
    • F Hefti 1986 Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transection J Neurosci 6 2155 2162
    • (1986) J Neurosci , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 43
    • 0021359024 scopus 로고
    • Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions
    • F Hefti A Dravid J Hartikka 1984 Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions Brain Res 293 305 311
    • (1984) Brain Res , vol.293 , pp. 305-311
    • Hefti, F.1    Dravid, A.2    Hartikka, J.3
  • 47
    • 4143121134 scopus 로고    scopus 로고
    • Intrabodies as therapeutic agents
    • RE Kontermann 2004 Intrabodies as therapeutic agents Methods 34 163 170
    • (2004) Methods , vol.34 , pp. 163-170
    • Kontermann, R.E.1
  • 49
    • 0023067115 scopus 로고
    • Nerve growth factor treatment after brain injury prevents neuronal death
    • LF Kromer 1987 Nerve growth factor treatment after brain injury prevents neuronal death Science 235 214 216
    • (1987) Science , vol.235 , pp. 214-216
    • Kromer, L.F.1
  • 51
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • HJ Lee S Patel SJ Lee 2005 Intravesicular localization and exocytosis of alpha-synuclein and its aggregates J Neurosci 25 6016 6024
    • (2005) J Neurosci , vol.25 , pp. 6016-6024
    • Lee, H.J.1    Patel, S.2    Lee, S.J.3
  • 52
    • 76549235314 scopus 로고
    • Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
    • R Levi-Montalcini V Hamburger 1951 Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo J Exp Zool 116 321 362
    • (1951) J Exp Zool , vol.116 , pp. 321-362
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 53
    • 4344650564 scopus 로고    scopus 로고
    • Dopamine and L-dopa disaggregate amyloid fibrils: Implications for Parkinson's and Alzheimer's disease
    • J Li M Zhu AB Manning-Bog DA Di Monte AL Fink 2004 Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease FASEB J 18 962 964
    • (2004) FASEB J , vol.18 , pp. 962-964
    • Li, J.1    Zhu, M.2    Manning-Bog, A.B.3    Di Monte, D.A.4    Fink, A.L.5
  • 54
    • 0028360088 scopus 로고
    • Immune responses of young mice to pneumococcal type 9V polysaccharide-tetanus toxoid conjugate
    • CH Lu CJ Lee P Kind 1994 Immune responses of young mice to pneumococcal type 9V polysaccharide-tetanus toxoid conjugate Infect Immun 62 2754 2760
    • (1994) Infect Immun , vol.62 , pp. 2754-2760
    • Lu, C.H.1    Lee, C.J.2    Kind, P.3
  • 55
    • 39649109675 scopus 로고    scopus 로고
    • An scFv intrabody against the nonamyloid component of alpha-synuclein reduces intracellular aggregation and toxicity
    • SM Lynch C Zhou A Messer 2008 An scFv intrabody against the nonamyloid component of alpha-synuclein reduces intracellular aggregation and toxicity J Mol Biol 377 136 147
    • (2008) J Mol Biol , vol.377 , pp. 136-147
    • Lynch, S.M.1    Zhou, C.2    Messer, A.3
  • 56
    • 0037713491 scopus 로고    scopus 로고
    • Convergent pathobiologic model of Parkinson's disease
    • KA Maguire-Zeiss HJ Federoff 2003 Convergent pathobiologic model of Parkinson's disease Ann N Y Acad Sci 991 152 166
    • (2003) Ann N y Acad Sci , vol.991 , pp. 152-166
    • Maguire-Zeiss, K.A.1    Federoff, H.J.2
  • 57
    • 6344244642 scopus 로고    scopus 로고
    • Safety of viral vectors for neurological gene therapies
    • KA Maguire-Zeiss HJ Federoff 2004 Safety of viral vectors for neurological gene therapies Curr Opin Mol Ther 6 473 481
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 473-481
    • Maguire-Zeiss, K.A.1    Federoff, H.J.2
  • 59
    • 15744405993 scopus 로고    scopus 로고
    • Synuclein, dopamine and oxidative stress: Co-conspirators in Parkinson's disease?
    • KA Maguire-Zeiss DW Short HJ Federoff 2005 Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res 134 18 23
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 18-23
    • Maguire-Zeiss, K.A.1    Short, D.W.2    Federoff, H.J.3
  • 61
    • 37549052950 scopus 로고    scopus 로고
    • Gazing into the future: Parkinson's disease gene therapeutics to modify natural history
    • KA Maguire-Zeiss TR Mhyre HJ Federoff 2007 Gazing into the future: Parkinson's disease gene therapeutics to modify natural history Exp Neurol 209 1 101 113
    • (2007) Exp Neurol , vol.209 , Issue.1 , pp. 101-113
    • Maguire-Zeiss, K.A.1    Mhyre, T.R.2    Federoff, H.J.3
  • 62
    • 0030225293 scopus 로고    scopus 로고
    • Analysis of antibody selection by phage display utilizing anti-phenobarbital antibodies
    • J Malone MA Sullivan 1996 Analysis of antibody selection by phage display utilizing anti-phenobarbital antibodies J Mol Recognit 9 738 745
    • (1996) J Mol Recognit , vol.9 , pp. 738-745
    • Malone, J.1    Sullivan, M.A.2
  • 63
    • 47349104402 scopus 로고    scopus 로고
    • Glial reactions in Parkinson's disease
    • PL McGeer EG McGeer 2008 Glial reactions in Parkinson's disease Mov Disord 23 474 483
    • (2008) Mov Disord , vol.23 , pp. 474-483
    • McGeer, P.L.1    McGeer, E.G.2
  • 64
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • PL McGeer S Itagaki BE Boyes EG McGeer 1988 Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Neurology 38 1285 1291
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • Itagaki, S.1    Boyes, B.E.2
  • 67
    • 36849059324 scopus 로고    scopus 로고
    • Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: Insights into the protein chemistry of Parkinson's disease
    • CE Moussa F Mahmoodian Y Tomita A Sidhu 2008 Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease Biochem Biophys Res Commun 365 833 839
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 833-839
    • Moussa, C.E.1    Mahmoodian, F.2    Tomita, Y.3    Sidhu, A.4
  • 69
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • JA Nicoll D Wilkinson C Holmes P Steart H Markham RO Weller 2003 Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report Nat Med 9 448 452
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 70
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • S Oddo A Caccamo M Kitazawa BP Tseng FM LaFerla 2003 Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease Neurobiol Aging 24 1063 1070
    • (2003) Neurobiol Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    Laferla, F.M.5
  • 71
  • 75
    • 3042655068 scopus 로고    scopus 로고
    • Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
    • RG Perez TG Hastings 2004 Could a loss of alpha-synuclein function put dopaminergic neurons at risk? J Neurochem 89 1318 1324
    • (2004) J Neurochem , vol.89 , pp. 1318-1324
    • Perez, R.G.1    Hastings, T.G.2
  • 78
    • 0035902194 scopus 로고    scopus 로고
    • Shattuck lecture-neurodegenerative diseases and prions
    • SB Prusiner 2001 Shattuck lecture-neurodegenerative diseases and prions N Engl J Med 344 1516 1526
    • (2001) N Engl J Med , vol.344 , pp. 1516-1526
    • Prusiner, S.B.1
  • 79
    • 0033118161 scopus 로고    scopus 로고
    • The effect of chromosomal translocations in acute leukemias: The LMO2 paradigm in transcription and development
    • TH Rabbitts K Bucher G Chung G Grutz A Warren Y Yamada 1999 The effect of chromosomal translocations in acute leukemias: the LMO2 paradigm in transcription and development Cancer Res 59 1794s 1798s
    • (1999) Cancer Res , vol.59
    • Rabbitts, T.H.1    Bucher, K.2    Chung, G.3    Grutz, G.4    Warren, A.5    Yamada, Y.6
  • 80
    • 0034531297 scopus 로고    scopus 로고
    • Building a better vector: The manipulation of AAV virions
    • JE Rabinowitz RJ Samulski 2000 Building a better vector: the manipulation of AAV virions Virology 278 301 308
    • (2000) Virology , vol.278 , pp. 301-308
    • Rabinowitz, J.E.1    Samulski, R.J.2
  • 85
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid beta-protein and the genetics of Alzheimer's disease
    • DJ Selkoe 1996 Amyloid beta-protein and the genetics of Alzheimer's disease J Biol Chem 271 18295 18298
    • (1996) J Biol Chem , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 86
    • 12744255421 scopus 로고    scopus 로고
    • Promoters and serotypes: Targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo
    • Z Shevtsova JM Malik U Michel M Bahr S Kugler 2005 Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo Exp Physiol 90 53 59
    • (2005) Exp Physiol , vol.90 , pp. 53-59
    • Shevtsova, Z.1    Malik, J.M.2    Michel, U.3    Bahr, M.4    Kugler, S.5
  • 87
    • 1842454976 scopus 로고    scopus 로고
    • Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    • A Sidhu C Wersinger P Vernier 2004 Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J 18 637 647
    • (2004) FASEB J , vol.18 , pp. 637-647
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 88
    • 2342496196 scopus 로고    scopus 로고
    • Alpha-Synuclein regulation of the dopaminergic transporter: A possible role in the pathogenesis of Parkinson's disease
    • A Sidhu C Wersinger P Vernier 2004 alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease FEBS Lett 565 1 5
    • (2004) FEBS Lett , vol.565 , pp. 1-5
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 89
    • 0025136826 scopus 로고
    • Survival of adult basal forebrain cholinergic neurons after loss of target neurons
    • MV Sofroniew NP Galletly O Isacson CN Svendsen 1990 Survival of adult basal forebrain cholinergic neurons after loss of target neurons Science 247 338 342
    • (1990) Science , vol.247 , pp. 338-342
    • Sofroniew, M.V.1    Galletly, N.P.2    Isacson, O.3    Svendsen, C.N.4
  • 90
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • JM Souza BI Giasson Q Chen VM Lee H Ischiropoulos 2000 Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies J Biol Chem 275 18344 18349
    • (2000) J Biol Chem , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 97
    • 34249941829 scopus 로고    scopus 로고
    • Nerve growth factor gene therapy in Alzheimer disease
    • MH Tuszynski 2007 Nerve growth factor gene therapy in Alzheimer disease Alzheimer Dis Assoc Disord 21 179 189
    • (2007) Alzheimer Dis Assoc Disord , vol.21 , pp. 179-189
    • Tuszynski, M.H.1
  • 98
    • 0025535753 scopus 로고
    • Potential use of neurotrophic agents in the treatment of neurodegenerative disorders
    • MH Tuszynski FH Gage 1990 Potential use of neurotrophic agents in the treatment of neurodegenerative disorders Acta Neurobiol Exp (Wars) 50 311 322
    • (1990) Acta Neurobiol Exp (Wars) , vol.50 , pp. 311-322
    • Tuszynski, M.H.1    Gage, F.H.2
  • 99
    • 37549032800 scopus 로고    scopus 로고
    • In vivo gene delivery for development of mammalian models for Parkinson's disease
    • A Ulusoy T Bjorklund S Hermening D Kirik 2008 In vivo gene delivery for development of mammalian models for Parkinson's disease Exp Neurol 209 89 100
    • (2008) Exp Neurol , vol.209 , pp. 89-100
    • Ulusoy, A.1    Bjorklund, T.2    Hermening, S.3    Kirik, D.4
  • 100
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure
    • VN Uversky J Li AL Fink 2001 Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure J Biol Chem 276 44284 44296
    • (2001) J Biol Chem , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 101
    • 0035815664 scopus 로고    scopus 로고
    • Evidence for a partially folded intermediate in alpha-synuclein fibril formation
    • VN Uversky J Li AL Fink 2001 Evidence for a partially folded intermediate in alpha-synuclein fibril formation J Biol Chem 276 10737 10744
    • (2001) J Biol Chem , vol.276 , pp. 10737-10744
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 102
    • 0035941305 scopus 로고    scopus 로고
    • Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations
    • VN Uversky HJ Lee J Li AL Fink SJ Lee 2001 Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations J Biol Chem 276 43495 43498
    • (2001) J Biol Chem , vol.276 , pp. 43495-43498
    • Uversky, V.N.1    Lee, H.J.2    Li, J.3    Fink, A.L.4    Lee, S.J.5
  • 103
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar alpha-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease
    • MJ Volles SJ Lee JC Rochet MD Shtilerman TT Ding JC Kessler PT Lansbury Jr 2001 Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease Biochemistry 40 7812 7819
    • (2001) Biochemistry , vol.40 , pp. 7812-7819
    • Volles, M.J.1    Lee, S.J.2    Rochet, J.C.3    Shtilerman, M.D.4    Ding, T.T.5    Kessler, J.C.6    Lansbury Jr, P.T.7
  • 104
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    • DM Wilcock SK Munireddy A Rosenthal KE Ugen MN Gordon D Morgan 2004 Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration Neurobiol Dis 15 11 20
    • (2004) Neurobiol Dis , vol.15 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3    Ugen, K.E.4    Gordon, M.N.5    Morgan, D.6
  • 105
    • 14244255355 scopus 로고    scopus 로고
    • Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    • DM Wilcock A Rojiani A Rosenthal S Subbarao MJ Freeman MN Gordon D Morgan 2004 Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage J Neuroinflammation 1 24
    • (2004) J Neuroinflammation , vol.1 , pp. 24
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3    Subbarao, S.4    Freeman, M.J.5    Gordon, M.N.6    Morgan, D.7
  • 107
    • 42149188850 scopus 로고    scopus 로고
    • Gamma-secretase inhibition and modulation for Alzheimer's disease
    • MS Wolfe 2008 Gamma-secretase inhibition and modulation for Alzheimer's disease Curr Alzheimer Res 5 158 164
    • (2008) Curr Alzheimer Res , vol.5 , pp. 158-164
    • Wolfe, M.S.1
  • 108
    • 39849085645 scopus 로고    scopus 로고
    • CNS delivery of vectored prion-specific single-chain antibodies delays disease onset
    • CA Wuertzer MA Sullivan X Qiu HJ Federoff 2008 CNS delivery of vectored prion-specific single-chain antibodies delays disease onset Mol Ther 16 481 486
    • (2008) Mol Ther , vol.16 , pp. 481-486
    • Wuertzer, C.A.1    Sullivan, M.A.2    Qiu, X.3    Federoff, H.J.4
  • 110
    • 10344257196 scopus 로고    scopus 로고
    • A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein
    • C Zhou S Emadi MR Sierks A Messer 2004 A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein Mol Ther 10 1023 1031
    • (2004) Mol Ther , vol.10 , pp. 1023-1031
    • Zhou, C.1    Emadi, S.2    Sierks, M.R.3    Messer, A.4


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