Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: Anti-amyloid-β antibody attenuates pathologies in an age-related macular degeneration mouse model

Vision Research

Volumn 48, Issue 3, 2008, Pages 339-345

  Ding, Jin Dong ^a   Lin, John ^b   Mace, Brian E ^c   Herrmann, Rolf ^a   Sullivan, Patrick ^c   Bowes Rickman, Catherine ^a,c  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b PFIZER INC   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age related macular degeneration (AMD); Alzheimer's disease; Amyloid; Choroidal neovascularization (CNV); Immunotherapy; Retinal pigment epithelium (RPE)

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN ANTIBODY; BRAIN PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRORETINOGRAM; HISTOLOGY; IMMUNOTHERAPY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; RETINA MACULA AGE RELATED DEGENERATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; IMMUNOTHERAPY; MACULAR DEGENERATION; MALE; MICE; MICE, INBRED C57BL; RETINA;

EID: 38749112528     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.visres.2007.07.025     Document Type: Article

References (39)

1. Anderson D.H., Talaga K.C., Rivest A.J., Barron E., Hageman G.S., and Johnson L.V. Characterization of beta amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration. Experimental Eye Research 78 2 (2004) 243-256
2. Arai T., Akiyama H., Ikeda K., Kondo H., and Mori H. Immunohistochemical localization of amyloid beta-protein with amino-terminal aspartate in the cerebral cortex of patients with Alzheimer's disease. Brain Research 823 1-2 (1999) 202-206
3. Baird P.N., Guida E., Chu D.T., Vu H.T., and Guymer R.H. The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Investigative Ophthalmology & Visual Science 45 5 (2004) 1311-1315
4. Blennow K., de Leon M.J., and Zetterberg H. Alzheimer's disease. Lancet 368 9533 (2006) 387-403
5. Canevari L., and Clark J.B. Alzheimer's disease and cholesterol: The fat connection. Neurochemical Research 32 4-5 (2007) 739-750
6. Carty N.C., Wilcock D.M., Rosenthal A., Grimm J., Pons J., Ronan V., Gottschall P.E., Gordon M.N., and Morgan D. Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. Journal of Neuroinflammation 3 (2006) 11
7. Dentchev T., Milam A.H., Lee V.M., Trojanowski J.Q., and Dunaief J.L. Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Molecular Vision 9 (2003) 184-190
8. Edwards A.O., Ritter III R., Abel K.J., Manning A., Panhuysen C., and Farrer L.A. Complement factor H polymorphism and age-related macular degeneration. Science 308 5720 (2005) 421-424
9. Evans K., and Bird A.C. The genetics of complex ophthalmic disorders. The British Journal of Ophthalmology 80 8 (1996) 763-768
10. Ferrer I., Boada Rovira M., Sanchez Guerra M.L., Rey M.J., and Costa-Jussa F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathology 14 1 (2004) 11-20
11. Hageman G.S., Anderson D.H., Johnson L.V., Hancox L.S., Taiber A.J., Hardisty L.I., Hageman J.L., Stockman H.A., Borchardt J.D., Gehrs K.M., Smith R.J., Silvestri G., Russell S.R., Klaver C.C., Barbazetto I., Chang S., Yannuzzi L.A., Barile G.R., Merriam J.C., Smith R.T., Olsh A.K., Bergeron J., Zernant J., Merriam J.E., Gold B., Dean M., and Allikmets R. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 102 20 (2005) 7227-7232
12. Haines J.L., Hauser M.A., Schmidt S., Scott W.K., Olson L.M., Gallins P., Spencer K.L., Kwan S.Y., Noureddine M., Gilbert J.R., Schnetz-Boutaud N., Agarwal A., Postel E.A., and Pericak-Vance M.A. Complement factor H variant increases the risk of age-related macular degeneration. Science 308 5720 (2005) 419-421
13. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297 5580 (2002) 353-356
14. Heiba I.M., Elston R.C., Klein B.E., and Klein R. Sibling correlations and segregation analysis of age-related maculopathy: The Beaver Dam Eye Study. Genetic Epidemiology 11 1 (1994) 51-67
15. Javitt J.C., Zhou Z., Maguire M.G., Fine S.L., and Willke R.J. Incidence of exudative age-related macular degeneration among elderly Americans. Ophthalmology 110 8 (2003) 1534-1539
16. Johnson L.V., Leitner W.P., Rivest A.J., Staples M.K., Radeke M.J., and Anderson D.H. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 99 18 (2002) 11830-11835
17. Klein M.L., Mauldin W.M., and Stoumbos V.D. Heredity and age-related macular degeneration. Observations in monozygotic twins. Archives of Ophthalmology 112 7 (1994) 932-937
18. Klein M.L., Schultz D.W., Edwards A., Matise T.C., Rust K., Berselli C.B., Trzupek K., Weleber R.G., Ott J., Wirtz M.K., and Acott T.S. Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Archives of Ophthalmology 116 8 (1998) 1082-1088
19. Klein R.J., Zeiss C., Chew E.Y., Tsai J.Y., Sackler R.S., Haynes C., Henning A.K., SanGiovanni J.P., Mane S.M., Mayne S.T., Bracken M.B., Ferris F.L., Ott J., Barnstable C., and Hoh J. Complement factor H polymorphism in age-related macular degeneration. Science 308 5720 (2005) 385-389
20. Krebs M.R., Bromley E.H., and Donald A.M. The binding of thioflavin-T to amyloid fibrils: Localisation and implications. Journal of Structural Biology 149 1 (2005) 30-37
21. LeVine III H. Quantification of beta-sheet amyloid fibril structures with thioflavin T. Methods in Enzymology 309 (1999) 274-284
22. Luibl V., Isas J.M., Kayed R., Glabe C.G., Langen R., and Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. Journal of Clinical Investigation 116 2 (2006) 378-385
23. Mahley R.W. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240 4852 (1988) 622-630
24. Malek, G., Jamison, J.A., Mace, B.E., Sullivan, P.M., & Bowes Rickman, C. (2007). Responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. Advances in Experimental Medicine and Biology, in press.
25. Malek G., Johnson L.V., Mace B.E., Saloupis P., Schmechel D.E., Rickman D.W., Toth C.A., Sullivan P.M., and Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America 102 33 (2005) 11900-11905
26. Masliah E., Hansen L., Adame A., Crews L., Bard F., Lee C., Seubert P., Games D., Kirby L., and Schenk D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 64 1 (2005) 129-131
27. Melnikova I. Therapies for Alzheimer's disease. Nature Reviews. Drug Discovery 6 5 (2007) 341-342
28. Mullins R.F., Russell S.R., Anderson D.H., and Hageman G.S. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB Journal 14 7 (2000) 835-846
29. Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., and Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report. Nature Medicine 9 4 (2003) 448-452
30. Orgogozo J.M., Gilman S., Dartigues J.F., Laurent B., Puel M., Kirby L.C., Jouanny P., Dubois B., Eisner L., Flitman S., Michel B.F., Boada M., Frank A., and Hock C. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61 1 (2003) 46-54
31. Piguet B., Wells J.A., Palmvang I.B., Wormald R., Chisholm I.H., and Bird A.C. Age-related Bruch's membrane change: A clinical study of the relative role of heredity and environment. The British Journal of Ophthalmology 77 7 (1993) 400-403
32. Puchtler H., and Sweat F. Congo red as a stain for fluorescence microscopy of amyloid. The Journal of Histochemistry and Cytochemistry 13 8 (1965) 693-694
33. Silvestri G., Johnston P.B., and Hughes A.E. Is genetic predisposition an important risk factor in age-related macular degeneration?. Eye 8 5 (1994) 564-568
34. Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nature Reviews. Neuroscience 4 1 (2003) 49-60
35. Sullivan P.M., Mezdour H., Aratani Y., Knouff C., Najib J., Reddick R.L., Quarfordt S.H., and Maeda N. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. Journal of Biological Chemistry 272 29 (1997) 17972-17980
36. van Leeuwen R., Klaver C.C., Vingerling J.R., Hofman A., and de Jong P.T. The risk and natural course of age-related maculopathy: Follow-up at 6 1/2 years in the Rotterdam study. Archives of Ophthalmology 121 4 (2003) 519-526
37. Wilcock D.M., Alamed J., Gottschall P.E., Grimm J., Rosenthal A., Pons J., Ronan V., Symmonds K., Gordon M.N., and Morgan D. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. Journal of Neuroscience 26 20 (2006) 5340-5346
38. Wilcock D.M., Rojiani A., Rosenthal A., Levkowitz G., Subbarao S., Alamed J., Wilson D., Wilson N., Freeman M.J., Gordon M.N., and Morgan D. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. Journal of Neuroscience 24 27 (2004) 6144-6151
39. Yoshida T., Ohno-Matsui K., Ichinose S., Sato T., Iwata N., Saido T.C., Hisatomi T., Mochizuki M., and Morita I. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. Journal of Clinical Investigation 115 10 (2005) 2793-2800