Investigation of the catalytic mechanism of a synthetic DNAzyme with protein-like functionality: An RNaseA mimic?

Journal of the American Chemical Society

Volumn 131, Issue 15, 2009, Pages 5648-5658

  Thomas, Jason M ^a   Yoon, Jung Ki ^a   Perrin, David M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BASE CATALYSIS; BIOMIMETIC CHEMISTRY; CATALYTIC MECHANISMS; CATALYTIC ROLE; DIASTEREOSELECTIVE; DIVALENT METAL ION; DNAZYME; ELECTROSTATIC STABILIZATION; MODIFIED NUCLEOTIDES; PHOSPHOROTHIOATE; RIBONUCLEASE A; RNA CLEAVAGE; SEQUENCE SPECIFICITY; SIDE CHAINS; SYNTHETIC DNA; TRANSITION STATE;

ACIDS; AMINES; BIOMIMETICS; CATALYSTS; ENZYMES; FUNCTIONAL GROUPS; LABELS; METAL IONS; NUCLEIC ACIDS; PLANTS (BOTANY); QUANTUM CHEMISTRY; RNA;

CATALYSIS;

CATION; DEOXYRIBONUCLEASE; IMIDAZOLE DERIVATIVE; METAL ION; RIBONUCLEASE A; AMINE; DEOXYRIBOZYME; DNAZYME, 9(25) 11T; DNAZYME, 9(25)-11T; PANCREATIC RIBONUCLEASE; PHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; BIOMIMETICS; CATALYSIS; ELECTRICITY; IONIC STRENGTH; PROTEIN FUNCTION; RNA CLEAVAGE; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; CHEMISTRY; METABOLISM; MOLECULAR MIMICRY; SYNTHESIS;

AMINES; CATALYSIS; DNA, CATALYTIC; IMIDAZOLES; MOLECULAR MIMICRY; PHOSPHATES; RIBONUCLEASE, PANCREATIC;

EID: 67849104696     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900125n     Document Type: Article

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