Mechanism of phosphatidylinositol-specific phospholipase C: Origin of unusually high nonbridging thio effects

Biochemistry

Volumn 40, Issue 18, 2001, Pages 5433-5439

  Kravchuk, Alexander V ^a,c   Zhao, Li ^a   Kubiak, Robert J ^b,d   Bruzik, Karol S ^b   Tsai, Ming Daw ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c STANFORD UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSTS; ENZYMES; OXYGEN; PHOSPHATES;

NONBRIDGING THIO EFFECTS;

BIOCHEMISTRY;

ARGININE; HISTIDINE; LYSINE; PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; RIBONUCLEASE A;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BACTERIAL PROTEINS; CYSTEINE; HUMANS; LIGANDS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDIC ACIDS; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; RATS; RIBONUCLEASE, PANCREATIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; THIONUCLEOTIDES;

EID: 0035826594     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi002372q     Document Type: Article

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