Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: A putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation

Nucleic Acids Research

Volumn 32, Issue 22, 2004, Pages 6660-6672

  Ting, Richard ^a   Thomas, Jason M ^a   Lermer, Leonard ^a   Perrin, David M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DEOXYRIBOZYME; DIVALENT CATION; DNA BASE; EDETIC ACID; ESTER DERIVATIVE; HYDROXIDE; IMIDAZOLE; METAL ION; NUCLEOSIDE TRIPHOSPHATE; NUCLEOTIDE; RIBONUCLEASE A; RIBOSE; RNA;

ANALYTICAL PARAMETERS; ARTICLE; BASE PAIRING; CHEMICAL MODIFICATION; COMBINATORIAL CHEMISTRY; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; DEGRADATION; DISSOCIATION; DNA FLANKING REGION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IONIC STRENGTH; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; MOLECULAR SIZE; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; STATISTICAL SIGNIFICANCE; STEADY STATE; STOP CODON; TEMPERATURE; TRANS ISOMER;

BASE SEQUENCE; CATIONS, DIVALENT; DNA, CATALYTIC; EDETIC ACID; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDORIBONUCLEASES; HYDROLYSIS; KINETICS; MAGNESIUM; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; RIBONUCLEASE, PANCREATIC; RNA; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 13544253729     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh1007     Document Type: Article

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