A comparison of vanadate to a 2′-5′ linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilization

RNA

Volumn 13, Issue 7, 2007, Pages 1052-1070

  Torelli, Andrew T ^a   Krucinska, Jolanta ^a   Wedekind, Joseph E ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

2 ,5 phosphodiester; Active site waters; Hairpin ribozyme; Reaction intermediate; Transition state stabilization; Vanadate

Indexed keywords

HAIRPIN RIBOZYME; HAMMERHEAD RIBOZYME; NUCLEIC ACID BASE; PHOSPHODIESTERASE; RIBOZYME; UNCLASSIFIED DRUG; WATER;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ELECTROCHEMISTRY; ENZYME ACTIVE SITE; ENZYME STABILITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RNA CONFORMATION; RNA STABILITY; RNA STRUCTURE; STRUCTURE ANALYSIS;

BASE SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PHASE TRANSITION; RNA STABILITY; RNA, CATALYTIC; VANADATES; WATER;

EID: 34250888277     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.510807     Document Type: Article

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