-
1
-
-
33751080094
-
Drug discovery and development for neglected parasitic diseases
-
Renslo A.R., and McKerrow J.H. Drug discovery and development for neglected parasitic diseases. Nat. Chem. Biol. 2 (2006) 701-710
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 701-710
-
-
Renslo, A.R.1
McKerrow, J.H.2
-
2
-
-
33845386531
-
Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
-
Abu-Raddad L.J., et al. Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science 314 (2006) 1603-1606
-
(2006)
Science
, vol.314
, pp. 1603-1606
-
-
Abu-Raddad, L.J.1
-
3
-
-
0033135736
-
Leishmania-HIV interaction: immunopathogenic mechanisms
-
Wolday D., et al. Leishmania-HIV interaction: immunopathogenic mechanisms. Parasitol. Today 15 (1999) 182-187
-
(1999)
Parasitol. Today
, vol.15
, pp. 182-187
-
-
Wolday, D.1
-
4
-
-
0032018033
-
Chagas' disease and HIV co-infection: genotypic characterization of the Trypanosoma cruzi strain
-
Pacheco R.S., et al. Chagas' disease and HIV co-infection: genotypic characterization of the Trypanosoma cruzi strain. Memórias do Instituto Oswaldo Cruz 93 (1998) 165-169
-
(1998)
Memórias do Instituto Oswaldo Cruz
, vol.93
, pp. 165-169
-
-
Pacheco, R.S.1
-
5
-
-
2542640961
-
A medicinal chemistry perspective on artemisinin and related endoperoxides
-
O'Neill P.M., and Posner G.H. A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 47 (2004) 2945-2964
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2945-2964
-
-
O'Neill, P.M.1
Posner, G.H.2
-
6
-
-
34249012765
-
New developments in synthetic peroxidic drugs as artemisinin mimics
-
Jefford C.W. New developments in synthetic peroxidic drugs as artemisinin mimics. Drug Discov. Today 12 (2007) 487-495
-
(2007)
Drug Discov. Today
, vol.12
, pp. 487-495
-
-
Jefford, C.W.1
-
7
-
-
0028068979
-
Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model
-
Janse C.J., et al. Comparison of in vivo and in vitro antimalarial activity of artemisinin, dihydroartemisinin and sodium artesunate in the Plasmodium berghei-rodent model. Int. J. Parasitol. 24 (1994) 589-594
-
(1994)
Int. J. Parasitol.
, vol.24
, pp. 589-594
-
-
Janse, C.J.1
-
8
-
-
0034813570
-
Artemisinin and its derivatives: an important new class of antimalarial agents
-
Balint G.A. Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol. Ther. 90 (2001) 261-265
-
(2001)
Pharmacol. Ther.
, vol.90
, pp. 261-265
-
-
Balint, G.A.1
-
10
-
-
33846864557
-
Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda
-
Bukirwa H., et al. Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin. Trials 1 (2006) e7
-
(2006)
PLoS Clin. Trials
, vol.1
-
-
Bukirwa, H.1
-
11
-
-
0037397498
-
The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria
-
Danis M., and Bricaire F. The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria. Fundam. Clin. Pharmacol. 17 (2003) 155-160
-
(2003)
Fundam. Clin. Pharmacol.
, vol.17
, pp. 155-160
-
-
Danis, M.1
Bricaire, F.2
-
12
-
-
67849107171
-
-
Poole S., (text editor) (2001) The use of anti-malarial drugs-a report by WHO (http://rbm.who.int/cmc_upload/0/000/014/923/use_of_antimalarials.pdf)
-
Poole S., (text editor) (2001) The use of anti-malarial drugs-a report by WHO (http://rbm.who.int/cmc_upload/0/000/014/923/use_of_antimalarials.pdf)
-
-
-
-
13
-
-
0027300830
-
Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity
-
Baker J.K., et al. Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity. Pharm. Res. 10 (1993) 662-666
-
(1993)
Pharm. Res.
, vol.10
, pp. 662-666
-
-
Baker, J.K.1
-
14
-
-
0027992488
-
Fatal neurotoxicity of arteether and artemether
-
Brewer T.G., et al. Fatal neurotoxicity of arteether and artemether. Am. J. Trop. Med. Hyg. 51 (1994) 251-259
-
(1994)
Am. J. Trop. Med. Hyg.
, vol.51
, pp. 251-259
-
-
Brewer, T.G.1
-
15
-
-
0028338629
-
Neurotoxicity in animals due to arteether and artemether
-
Brewer T.G., et al. Neurotoxicity in animals due to arteether and artemether. Trans. R. Soc. Trop. Med. Hyg. 88 Suppl. 1 (1994) 33-36
-
(1994)
Trans. R. Soc. Trop. Med. Hyg.
, vol.88
, Issue.SUPPL. 1
, pp. 33-36
-
-
Brewer, T.G.1
-
16
-
-
1642482269
-
Artemisinin derivatives: toxic for laboratory animals, safe for humans?
-
Gordi T., and Lepist E.-I. Artemisinin derivatives: toxic for laboratory animals, safe for humans?. Toxicol. Lett. 147 (2004) 99-107
-
(2004)
Toxicol. Lett.
, vol.147
, pp. 99-107
-
-
Gordi, T.1
Lepist, E.-I.2
-
17
-
-
0023555532
-
Antimalarial activity of new water-soluble dihydroartemisinin derivatives
-
Lin A.J., et al. Antimalarial activity of new water-soluble dihydroartemisinin derivatives. J. Med. Chem. 30 (1987) 2147-2150
-
(1987)
J. Med. Chem.
, vol.30
, pp. 2147-2150
-
-
Lin, A.J.1
-
18
-
-
67849094898
-
-
Hartell, M.G. et al. (2003) Artemisinins with improved stability and bioavailability for therapeutic drug development and application. US patent applications 7084132 B2 and 6951846 B2
-
Hartell, M.G. et al. (2003) Artemisinins with improved stability and bioavailability for therapeutic drug development and application. US patent applications 7084132 B2 and 6951846 B2
-
-
-
-
20
-
-
33745975677
-
Artemisone-a highly active antimalarial drug of the artemisinin class
-
Haynes R.K., et al. Artemisone-a highly active antimalarial drug of the artemisinin class. Angew. Chem. 45 (2006) 2082-2088
-
(2006)
Angew. Chem.
, vol.45
, pp. 2082-2088
-
-
Haynes, R.K.1
-
21
-
-
34249983249
-
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo
-
Vivas L., et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J. Antimicrob. Chemother. 59 (2007) 658-665
-
(2007)
J. Antimicrob. Chemother.
, vol.59
, pp. 658-665
-
-
Vivas, L.1
-
22
-
-
50949086688
-
First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone
-
Nagelschmitz J., et al. First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone. Antimicrob. Agents Chemother. 52 (2008) 3085-3091
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3085-3091
-
-
Nagelschmitz, J.1
-
23
-
-
0035804312
-
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin
-
O'Neill P.M., et al. Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin. J. Med. Chem. 44 (2001) 58-68
-
(2001)
J. Med. Chem.
, vol.44
, pp. 58-68
-
-
O'Neill, P.M.1
-
24
-
-
2342517468
-
Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate
-
Magueur G., et al. Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate. J. Med. Chem. 47 (2004) 2694-2699
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2694-2699
-
-
Magueur, G.1
-
25
-
-
0037122747
-
Structure-activity relationships of the antimalarial agent artemisinin, 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies
-
and references therein
-
Avery M.A., et al. Structure-activity relationships of the antimalarial agent artemisinin, 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies. J. Med. Chem. 45 (2002) 292-303 and references therein
-
(2002)
J. Med. Chem.
, vol.45
, pp. 292-303
-
-
Avery, M.A.1
-
26
-
-
0037068498
-
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates
-
Avery M.A., et al. Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. J. Med. Chem. 45 (2002) 4321-4335
-
(2002)
J. Med. Chem.
, vol.45
, pp. 4321-4335
-
-
Avery, M.A.1
-
27
-
-
12144291704
-
Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin
-
Grellepois F., et al. Orally active antimalarials: hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin. J. Med. Chem. 47 (2004) 1423-1433
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1423-1433
-
-
Grellepois, F.1
-
28
-
-
0037194666
-
Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents
-
Posner G.H., et al. Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. J. Med. Chem. 45 (2002) 3824-3828
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3824-3828
-
-
Posner, G.H.1
-
29
-
-
0029619657
-
Structure-activity relationships of the antimalarial agent artemisinin, 2. Effect of heteroatom substitution at O-11: synthesis and bioassay of N-alkyl-11-aza-9-desmethylartemisinins
-
Avery M.A., et al. Structure-activity relationships of the antimalarial agent artemisinin, 2. Effect of heteroatom substitution at O-11: synthesis and bioassay of N-alkyl-11-aza-9-desmethylartemisinins. J. Med. Chem. 38 (1995) 5038-5044
-
(1995)
J. Med. Chem.
, vol.38
, pp. 5038-5044
-
-
Avery, M.A.1
-
30
-
-
0032510451
-
Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation
-
Posner G.H., et al. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. J. Med. Chem. 41 (1998) 940-951
-
(1998)
J. Med. Chem.
, vol.41
, pp. 940-951
-
-
Posner, G.H.1
-
31
-
-
0032510380
-
Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogs of the antimalarial artemisinin
-
Cumming J.N., et al. Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogs of the antimalarial artemisinin. J. Med. Chem. 41 (1998) 952-964
-
(1998)
J. Med. Chem.
, vol.41
, pp. 952-964
-
-
Cumming, J.N.1
-
32
-
-
0028155988
-
Synthesis, conformational analysis, and antimalarial activity of tricyclic analogs of artemisinin
-
Avery M.A., et al. Synthesis, conformational analysis, and antimalarial activity of tricyclic analogs of artemisinin. Tetrahedron 50 (1994) 957-972
-
(1994)
Tetrahedron
, vol.50
, pp. 957-972
-
-
Avery, M.A.1
-
33
-
-
34249097684
-
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives
-
Posner G.H., et al. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. J. Med. Chem. 50 (2007) 2516-2519
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2516-2519
-
-
Posner, G.H.1
-
34
-
-
0141680852
-
Structure-activity relationships of the antimalarial agent artemisinin. 8. Design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria
-
Avery M.A., et al. Structure-activity relationships of the antimalarial agent artemisinin. 8. Design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. J. Med. Chem. 46 (2003) 4244-4258
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4244-4258
-
-
Avery, M.A.1
-
35
-
-
4644311700
-
Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegans
-
Parshikov I.A., et al. Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegans. J. Nat. Prod. 67 (2004) 1595-1597
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1595-1597
-
-
Parshikov, I.A.1
-
36
-
-
3142770578
-
Transformation of artemisinin by Cunninghamella elegans
-
Parshikov I.A., et al. Transformation of artemisinin by Cunninghamella elegans. Appl. Microbiol. Biotechnol. 64 (2004) 782-786
-
(2004)
Appl. Microbiol. Biotechnol.
, vol.64
, pp. 782-786
-
-
Parshikov, I.A.1
-
37
-
-
0036853803
-
Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger
-
Zhan J.-X., et al. Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger. J. Nat. Prod. 65 (2002) 1693-1695
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 1693-1695
-
-
Zhan, J.-X.1
-
38
-
-
0346725018
-
Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin
-
Selmeczi K., et al. Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin. FEBS Lett. 556 (2004) 245-248
-
(2004)
FEBS Lett.
, vol.556
, pp. 245-248
-
-
Selmeczi, K.1
-
39
-
-
0036009409
-
From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs
-
Robert A., et al. From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. Acc. Chem. Res. 35 (2002) 167-174
-
(2002)
Acc. Chem. Res.
, vol.35
, pp. 167-174
-
-
Robert, A.1
-
40
-
-
2942666622
-
Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity
-
Haynes R.K., et al. Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity. Angew. Chem. 43 (2004) 1381-1385
-
(2004)
Angew. Chem.
, vol.43
, pp. 1381-1385
-
-
Haynes, R.K.1
-
41
-
-
17044427198
-
Reply to comments on 'Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity'
-
Haynes R.K. Reply to comments on 'Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity'. Angew. Chem. 44 (2005) 2064-2065
-
(2005)
Angew. Chem.
, vol.44
, pp. 2064-2065
-
-
Haynes, R.K.1
-
42
-
-
34548293148
-
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
-
Stocks P.A., et al. Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angew. Chem. 46 (2007) 6278-6283
-
(2007)
Angew. Chem.
, vol.46
, pp. 6278-6283
-
-
Stocks, P.A.1
-
43
-
-
0032568952
-
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin
-
Bhisutthibhan J., et al. The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J. Biol. Chem. 273 (1998) 16192-16198
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16192-16198
-
-
Bhisutthibhan, J.1
-
44
-
-
0036009325
-
Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization
-
Kannan R., et al. Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization. Chem. Biol. 9 (2002) 321-332
-
(2002)
Chem. Biol.
, vol.9
, pp. 321-332
-
-
Kannan, R.1
-
45
-
-
0034700205
-
A possible antimalarial action mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centered primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoxyphenyl)-12-deoxoqinghaosu
-
Wang D.-Y., and Wu Y.-L. A possible antimalarial action mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centered primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoxyphenyl)-12-deoxoqinghaosu. Chem. Commun. 22 (2000) 2193-2194
-
(2000)
Chem. Commun.
, vol.22
, pp. 2193-2194
-
-
Wang, D.-Y.1
Wu, Y.-L.2
-
46
-
-
0042860063
-
Artemisinins target the SERCA of Plasmodium falciparum
-
Eckstein-Ludwig U., et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 (2003) 957-961
-
(2003)
Nature
, vol.424
, pp. 957-961
-
-
Eckstein-Ludwig, U.1
-
47
-
-
26444465676
-
The antimalarial drug artemisinin alkylates heme in infected mice
-
Robert A., et al. The antimalarial drug artemisinin alkylates heme in infected mice. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 13676-13680
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 13676-13680
-
-
Robert, A.1
-
48
-
-
28244477359
-
Resistance of Plasmodium falciparum field isolates to in vitro artemether and point mutations of the SERCA-type PfATPase6
-
Jambou R., et al. Resistance of Plasmodium falciparum field isolates to in vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366 (2005) 1960-1963
-
(2005)
Lancet
, vol.366
, pp. 1960-1963
-
-
Jambou, R.1
-
49
-
-
3042613588
-
Synthetic peroxides as antimalarials
-
Tang Y., et al. Synthetic peroxides as antimalarials. Med. Res. Rev. 24 (2004) 425-448
-
(2004)
Med. Res. Rev.
, vol.24
, pp. 425-448
-
-
Tang, Y.1
-
50
-
-
0035207181
-
Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action
-
Jefford C.W. Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action. Curr. Med. Chem. 8 (2001) 1803-1826
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1803-1826
-
-
Jefford, C.W.1
-
51
-
-
0027280239
-
The chemotherapy of rodent malaria. XLIX. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 2: structure-activity studies on cis-fused cyclopenteno-1,2,4-trioxanes (fenozans) against drug-sensitive and drug-resistant lines of Plasmodium berghei and P. yoelii ssp. NS in vivo
-
Peters W., et al. The chemotherapy of rodent malaria. XLIX. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 2: structure-activity studies on cis-fused cyclopenteno-1,2,4-trioxanes (fenozans) against drug-sensitive and drug-resistant lines of Plasmodium berghei and P. yoelii ssp. NS in vivo. Ann. Trop. Med. Parasitol. 87 (1993) 9-16
-
(1993)
Ann. Trop. Med. Parasitol.
, vol.87
, pp. 9-16
-
-
Peters, W.1
-
52
-
-
35848951630
-
Evaluation of some adamantane-based synthetic trioxanes against Plasmodium knowlesi in rhesus monkeys
-
Tripathi R., et al. Evaluation of some adamantane-based synthetic trioxanes against Plasmodium knowlesi in rhesus monkeys. Life Sci. 81 (2007) 1544-1548
-
(2007)
Life Sci.
, vol.81
, pp. 1544-1548
-
-
Tripathi, R.1
-
53
-
-
0028170770
-
Ro 42-1611 (arteflene), a new effective antimalarial: chemical structure and biological activity
-
Hofheinz W., et al. Ro 42-1611 (arteflene), a new effective antimalarial: chemical structure and biological activity. Trop. Med. Parasitol. 45 (1994) 261-265
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 261-265
-
-
Hofheinz, W.1
-
54
-
-
0038440391
-
A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides
-
Bachi M.D., et al. A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides. J. Med. Chem. 46 (2003) 2516-2533
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2516-2533
-
-
Bachi, M.D.1
-
55
-
-
4544263432
-
Design and synthesis of endoperoxide antimalarial prodrug models
-
O'Neill P.M., et al. Design and synthesis of endoperoxide antimalarial prodrug models. Angew. Chem. 43 (2004) 4193-4197
-
(2004)
Angew. Chem.
, vol.43
, pp. 4193-4197
-
-
O'Neill, P.M.1
-
56
-
-
4344630762
-
Identification of an antimalarial synthetic trioxolane drug development candidate
-
Vennerstrom J.L., et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430 (2004) 900-904
-
(2004)
Nature
, vol.430
, pp. 900-904
-
-
Vennerstrom, J.L.1
-
57
-
-
67849104407
-
Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis
-
US patent applications: 6825230B2 (2004, 6486199 B1 (2002) and 6906205 B2
-
Vennerstrom, J.L. et al. (2005) Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis. US patent applications: 6825230B2 (2004); 6486199 B1 (2002) and 6906205 B2
-
(2005)
-
-
Vennerstrom, J.L.1
-
58
-
-
37549066714
-
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models
-
Snyder C., et al. In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models. Exp. Parasitol. 115 (2007) 296-300
-
(2007)
Exp. Parasitol.
, vol.115
, pp. 296-300
-
-
Snyder, C.1
-
60
-
-
67849105299
-
-
Press release in the web (http://www.bseindia.com/xml-data/corpfiling/announcement/Ranbaxy_Labora tories_Ltd_160908.pdf)
-
Press release in the web
-
-
-
61
-
-
0036546934
-
Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes
-
Dong Y. Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes. Mini-Rev. Med. Chem. 2 (2002) 113-123
-
(2002)
Mini-Rev. Med. Chem.
, vol.2
, pp. 113-123
-
-
Dong, Y.1
-
62
-
-
0033566212
-
Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7-pentoxocanes and 1,2,4,5-tetroxanes
-
Kim H.-S., et al. Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7-pentoxocanes and 1,2,4,5-tetroxanes. J. Med. Chem. 42 (1999) 2604-2609
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2604-2609
-
-
Kim, H.-S.1
-
63
-
-
0035811454
-
Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
-
Kim H.-S., et al. Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes. J. Med. Chem. 44 (2001) 2357-2361
-
(2001)
J. Med. Chem.
, vol.44
, pp. 2357-2361
-
-
Kim, H.-S.1
-
64
-
-
34548458522
-
Exploitation of bile acid transport systems in prodrug design
-
Sievänen E. Exploitation of bile acid transport systems in prodrug design. Molecules 12 (2007) 1859-1889
-
(2007)
Molecules
, vol.12
, pp. 1859-1889
-
-
Sievänen, E.1
-
65
-
-
0034710713
-
Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity
-
Opsenica D., et al. Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity. J. Med. Chem. 43 (2000) 3274-3282
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3274-3282
-
-
Opsenica, D.1
-
66
-
-
0036682037
-
Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity
-
Šolaja B.A., et al. Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity. J. Med. Chem. 45 (2002) 3331-3336
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3331-3336
-
-
Šolaja, B.A.1
-
67
-
-
34250195398
-
A novel artemisinin-quinine hybrid with potent antimalarial activity
-
Walsh J.J., et al. A novel artemisinin-quinine hybrid with potent antimalarial activity. Bioorg. Med. Chem. Lett. 17 (2007) 3599-3602
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3599-3602
-
-
Walsh, J.J.1
-
68
-
-
34948841945
-
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine
-
Loup C., et al. Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine. Antimicrob. Agents Chemother. 51 (2007) 3768-3770
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3768-3770
-
-
Loup, C.1
-
69
-
-
11144357467
-
Synthesis and antimalarial activity of trioxaquine derivatives
-
Dechy-Cabaret O., et al. Synthesis and antimalarial activity of trioxaquine derivatives. Chem. Eur. J. 10 (2004) 1625-1636
-
(2004)
Chem. Eur. J.
, vol.10
, pp. 1625-1636
-
-
Dechy-Cabaret, O.1
-
70
-
-
0027523748
-
Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis
-
Yang D.M., and Liew F.Y. Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis. Parasitology 106 (1993) 7-11
-
(1993)
Parasitology
, vol.106
, pp. 7-11
-
-
Yang, D.M.1
Liew, F.Y.2
-
71
-
-
34248369669
-
Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth
-
Mishina Y.V., et al. Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob. Agents Chemother. 51 (2007) 1852-1854
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 1852-1854
-
-
Mishina, Y.V.1
-
72
-
-
33845276523
-
A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities
-
Menon R.B., et al. A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities. Comb. Chem. High Throughput Screen. 9 (2006) 729-741
-
(2006)
Comb. Chem. High Throughput Screen.
, vol.9
, pp. 729-741
-
-
Menon, R.B.1
-
73
-
-
34748914190
-
Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes
-
Sen R., et al. Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes. J. Med. Microbiol. 56 (2007) 1213-1218
-
(2007)
J. Med. Microbiol.
, vol.56
, pp. 1213-1218
-
-
Sen, R.1
-
74
-
-
33845268199
-
In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin
-
Jones-Brando L., et al. In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. Antimicrob. Agents Chemother. 50 (2006) 4206-4208
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 4206-4208
-
-
Jones-Brando, L.1
-
75
-
-
0025146047
-
Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives
-
Ke O.Y., et al. Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives. Antimicrob. Agents Chemother. 34 (1990) 1961-1965
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 1961-1965
-
-
Ke, O.Y.1
-
77
-
-
0035211343
-
Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites
-
Utzinger J., et al. Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites. Curr. Med. Chem. 8 (2001) 1841-1859
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 1841-1859
-
-
Utzinger, J.1
-
78
-
-
0035217959
-
The potential of artemether for the control of schistosomiasis
-
Utzinger J., et al. The potential of artemether for the control of schistosomiasis. Int. J. Parasitol. 31 (2001) 1549-1562
-
(2001)
Int. J. Parasitol.
, vol.31
, pp. 1549-1562
-
-
Utzinger, J.1
-
79
-
-
31044454267
-
Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
-
Lu S., et al. Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols. Parasitol. Int. 55 (2006) 63-68
-
(2006)
Parasitol. Int.
, vol.55
, pp. 63-68
-
-
Lu, S.1
-
80
-
-
26844463805
-
A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China
-
Li Y.-S., et al. A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China. Acta Tropica 96 (2005) 184-190
-
(2005)
Acta Tropica
, vol.96
, pp. 184-190
-
-
Li, Y.-S.1
-
81
-
-
40849097597
-
Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation
-
Ikuhiko N., et al. Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation. Int. J. Pharm. 354 (2008) 28-33
-
(2008)
Int. J. Pharm.
, vol.354
, pp. 28-33
-
-
Ikuhiko, N.1
-
82
-
-
33845879363
-
Anticancer activity of artemisinin-derived trioxanes
-
Posner G.H., et al. Anticancer activity of artemisinin-derived trioxanes. Expert Opin. Ther. Pat. 16 (2006) 1665-1672
-
(2006)
Expert Opin. Ther. Pat.
, vol.16
, pp. 1665-1672
-
-
Posner, G.H.1
-
83
-
-
67849123026
-
-
Posner, G.H. et al, 2007 Trioxane dimers (artemisinin derivatives) having anticancer and antimalarial activities, processes for preparing them, and pharmaceutical compositions containing them. US patent application 6586464 B2
-
Posner, G.H. et al. (2007) Trioxane dimers (artemisinin derivatives) having anticancer and antimalarial activities, processes for preparing them, and pharmaceutical compositions containing them. US patent application 6586464 B2
-
-
-
-
84
-
-
30344465331
-
Novel endoperoxides: synthesis and activity against Candida species
-
Macreadie P., et al. Novel endoperoxides: synthesis and activity against Candida species. Bioorg. Med. Chem. Lett. 16 (2006) 920-922
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 920-922
-
-
Macreadie, P.1
-
85
-
-
24744456684
-
Antifungal activity of artemisinin derivatives
-
Galal A.M., et al. Antifungal activity of artemisinin derivatives. J. Nat. Prod. 68 (2005) 1274-1276
-
(2005)
J. Nat. Prod.
, vol.68
, pp. 1274-1276
-
-
Galal, A.M.1
-
86
-
-
0033083665
-
Peroxy natural products
-
Casteel D.A. Peroxy natural products. Nat. Prod. Rep. 16 (1999) 55-73
-
(1999)
Nat. Prod. Rep.
, vol.16
, pp. 55-73
-
-
Casteel, D.A.1
-
87
-
-
17744377209
-
Total syntheses of Yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities
-
see Liang, X. T. et al. (1979) Acta Chim. Sin., 37, 215-230 for details on its isolation
-
Szpilman A.M., et al. Total syntheses of Yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities. J. Org. Chem. 70 9 (2005) 3618-3632 see Liang, X. T. et al. (1979) Acta Chim. Sin., 37, 215-230 for details on its isolation
-
(2005)
J. Org. Chem.
, vol.70
, Issue.9
, pp. 3618-3632
-
-
Szpilman, A.M.1
-
88
-
-
0032510297
-
Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots
-
Takaya Y., et al. Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots. Tetrahedron Lett. 39 (1998) 1361-1364
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 1361-1364
-
-
Takaya, Y.1
-
89
-
-
0034703382
-
Novel Guaiane endoperoxides, Nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities
-
Takaya Y., et al. Novel Guaiane endoperoxides, Nardoguaianone A-D, from Nardostachys chinensis roots and their antinociceptive and antimalarial activities. Tetrahedron 56 (2000) 7673-7678
-
(2000)
Tetrahedron
, vol.56
, pp. 7673-7678
-
-
Takaya, Y.1
-
90
-
-
0028925926
-
An antimalarial peroxide from Amomum krervanh Pierre
-
Kamchonwongpaisan S., et al. An antimalarial peroxide from Amomum krervanh Pierre. Tetrahedron Lett. 36 (1995) 1821-1824
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 1821-1824
-
-
Kamchonwongpaisan, S.1
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