Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: Structure and antimalarial and antiproliferative activity

Journal of Medicinal Chemistry

Volumn 43, Issue 17, 2000, Pages 3274-3282

  Opsenica, D ^a   Pocsfalvi, G ^b   Juranic, Z ^c   Tinant, B ^d   Declercq, J P ^d   Kyle, D E ^e   Milhous, W K ^e   Solaja, B A ^f  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CNR   (Italy)

^c Department of Pathology   (Serbia)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^e WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^f UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; CHLOROQUINE; CHOLIC ACID DERIVATIVE; CYCLOHEXANE; ESTER;

ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHIRALITY; DIASTEREOISOMER; DRUG STRUCTURE; HUMAN; HUMAN CELL; MALARIA; MELANOMA CELL; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; UTERINE CERVIX CARCINOMA;

ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CHOLIC ACIDS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034710713     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000952f     Document Type: Article

References (53)

1. A blueprint of 'bad air'
2. Dispiro-1,2,4,5-tetraoxanes: A new class of antimalarial peroxides
3. Qinghaosu (Artemisinin): An antimalarial drug from China
4. The chemistry, pharmacology, and clinical applications of Qinghaosu (Artemisinin) and its derivatives
5. Artemisinin (Qinghaosu): A new type of antimalarial drug
6. Antimalarial activity of new water-soluble dihydroartemisinin derivatives
7. Design, synthesis, derivatization and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin
8. A carbonyl oxide route to antimalarial Yingzhaosu A analogues: Synthesis and antimalarial activity
9. Synthesis and antimalarial activities of fluoroalkyl derivatives of dihydroartemisinin
10. Orally active, hydrolitically stabile, semisynthetic, antimalarial trioxanes in the artemisinin family
11. Antimalarial, antiproliferative, and antitumor activities of Artemisinin-derived, chemically robust, trioxane dimers
12. Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether
13. Novel antimalarial guaiane-type sesquiterpenolds from Nardostachys chinensis roots
14. Antimalarial cyclic peroxy ketals
15. New types of potentially antimalarial agents: Epidoxy-substituted norditerpene and norsesterpenes from the marine sponge diacarnus levii
16. A new type of 1,2,4-trioxanes structurally related to antimalarial artemisinin
17. Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
18. Synthesis and antimalarial activity of 11 dispire-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-tetraoxadispiro-[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and Polar Functional Groups
19. Synthesis, crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes
20. Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7-pentoxocanes and 1,2,4,5-tetroxanes
21. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
22. Structure of peroxides derived from cyclohexanone and hydrogen peroxide
23. A simple laboratory method for the preparation of (Dimeric) ketone peroxides
24. Macrocycles. The synthesis and thermal decomposition of some disubstituted dicyclohexylidene diperoxides
25. An improved synthesis of dicyclohexylidene diperoxide
26. A simple synthesis of dicyclohexylidene diperoxide and tricyclohexylidene triperoxide
27. The preparation of dicyclohexylidene diperoxides by a two-step procedure
28. Ketone-derived peroxides. Part I. Synthetic methods
29. Efficient preparation of 1,2,4,5-tetroxanes from bis(trimethylsilyl) peroxide and carbonyl compounds
30. Dispiro-1,2,4,5-tetraoxanes via ozonolysis of cycloalkanone O-methyl oximes: A comparison with the peroxidation of cycloalkanones in acetonitrile-sulfuric acid media
31. Synthetic methods for unsymmetrically substituted 1,2,4,5-tetroxanes and of 1,2,4,5,7-pentoxocanes
32. Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity
33. New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite
34. Morphological and biochemical assays of apoptosis
35. Dunnschichtchromatographische identifizierung organischer peroxide
36. An extremely fast and efficient acylation reaction of alcohols with acid anhydrides in the presence of trimethylsilyl trifluoromethane-sulfonate as catalyst
37. Uber Beziehugen zwischen konstitution und optischer drehung in der Cholsaure-Reihe
38. Basic derivatives of steroids. 3-amino-7,12-dihydroxy- and 3-amino-12-hydroxy-cholanic acid
39. Phase annealing in SHELX-90: Direct methods for larger structures
40. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
41. In vitro activities of and mechanisms of resistance to antifol antimalarial drugs
42. Plasmodium falciparum: Induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro
43. The mechanism of 8-Cl-cAMP action