Orally active, water-soluble antimalarial 3-aryltrioxanes: Short synthesis and preclinical efficacy testing in rodents

Journal of Medicinal Chemistry

Volumn 45, Issue 18, 2002, Pages 3824-3828

  Posner, Gary H ^a   Jeon, Heung Bae ^a   Ploypradith, Poonsakdi ^a,b   Paik, Ik Hyeon ^a   Borstnik, Kristina ^a   Xie, Suji ^c,d   Shapiro, Theresa A ^c,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Toxicology and Management of Chemicals   (Thailand)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CARBOXYPHENYLTRIOXANE DERIVATIVE; ANTIMALARIAL AGENT; ARTELINIC ACID; CYCLOHEXANONE; TRIOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; HERB; MALARIA; MOUSE; NONHUMAN; STEREOISOMERISM; THERMOSTABILITY;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; BENZOIC ACIDS; BENZOXEPINS; MALARIA; MICE; PLASMODIUM BERGHEI; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037194666     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020210h     Document Type: Article

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