Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots

Tetrahedron Letters

Volumn 39, Issue 11, 1998, Pages 1361-1364

  Takaya, Yoshiaki ^a   Kurumada, Ken Ichi ^a   Takeuji, Yoshie ^a   Kim, Hye Sook ^b   Shibata, Yasuharu ^b   Ikemoto, Naomi ^b   Wataya, Yusuke ^b   Oshima, Yoshiteru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ENDOPEROXIDE; SESQUITERPENOID;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; MALARIA; NONHUMAN; PLANT ROOT; PLASMODIUM FALCIPARUM;

EID: 0032510297     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10844-9     Document Type: Article

References (5)

1. 1. Bagchi, A.; Oshima, Y.; Hikino, H. Phytochemistry 1988, 27, 3667-3669.
2. 2. Schulte, K. E.; Rücker, G.; Glauch, G. Planta Med. 1967, 15, 274-281.
3. 3. Bagchi, A.; Oshima, Y.; Hikino, H. Tetrahedron 1990, 46, 1523-1530.
4. 4. Breitmaier, E.; Voelter, W. Carbon-13 NMR Spectroscopy, VCH: New York, 1987; p. 218.
5. 3) δ 8.15 (2H, br. d,J=7.5, OBz), 7.58 (1H, tt,J=1.5, 7.5, OBz), 7.45 (2H, br. t,J=7.5, OBz), 6.13 (1H, s, H-6), 2.84 (1H, dq,J=1.0, 6.9, H-4), 2.73 (1H, dd,J=6.6, 18.5, H-3), 2.08 (1H, dd,J=1.2, 18.5, H-3), 1.99 (1H, ddd,J=6.5, 13.7, 17.7, H-9), 1.85 (1H, dd,J=8.4, 13.7, H-8), 1.66 (3H, s, H-15), 1.33 (3H, d,J=6.9, H-14), 1.18 (1H, ddd,J=8.7, 10.0, 13.8, H-8), 0.92 (3H, d,J=6.9, H-13), 0.90 (3H, d,J=6.9, H-12).