Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 292-303

  Avery, Mitchell A ^a,b   Alvim Gaston, Maria ^a,c   Rodrigues, Carlos R ^d   Barreiro, Eliezer J ^d   Cohen, Fred E ^e   Sabnis, Yogesh A ^a   Woolfrey, John R ^a,f  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISIN; ARTESUNATE; SESQUITERPENE;

ARTICLE; BRAIN MALARIA; DRUG CONFORMATION; NEUROTOXICITY; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTIMALARIALS; ARTEMISININS; DATABASES, FACTUAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REPRODUCIBILITY OF RESULTS; SESQUITERPENES; STEREOISOMERISM;

EID: 0037122747     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0100234     Document Type: Article

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