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Volumn 2, Issue 12, 2006, Pages 701-710

Drug discovery and development for neglected parasitic diseases

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINE DERIVATIVE; AMPHOTERICIN B; ANTIPARASITIC AGENT; ARTEMISININ DERIVATIVE; ASPARTIC PROTEINASE; CYSTEINE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; CYTIDINE TRIPHOSPHATE SYNTHASE; DB 289; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DIAMIDINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; EFLORNITHINE; HYDRAZIDE; MELARSOPROL; METHOTREXATE; PENTAMIDINE DERIVATIVE; PENTAMIDINE ISETHIONATE; PLASMEPSIN I; PLASMEPSIN II; PRAZIQUANTEL; PROTEINASE INHIBITOR; PYRIMETHAMINE; PYRIMIDINE; SERINE PROTEINASE; SULFONE DERIVATIVE; THIOSEMICARBAZONE; TREXALL; TRIMETHOPRIM; TRIMETHOPRIM DERIVATIVE; UNINDEXED DRUG; VINYL DERIVATIVE;

EID: 33751080094     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio837     Document Type: Review
Times cited : (300)

References (132)
  • 1
    • 33750518467 scopus 로고    scopus 로고
    • Designing drugs for parasitic diseases of the developing world
    • McKerrow, J.H. Designing drugs for parasitic diseases of the developing world. PLoS Med. 2, e210 (2005).
    • (2005) PLoS Med. , vol.2
    • McKerrow, J.H.1
  • 2
    • 0031024171 scopus 로고    scopus 로고
    • Experimenal and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A., Lombardo, F., Dominy, B.W. & Feeney, P.J. Experimenal and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3-25 (1997).
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 3
    • 0030883947 scopus 로고    scopus 로고
    • Validating targets for antiparasite chemotherapy
    • Wang, C.C. Validating targets for antiparasite chemotherapy. Parasitology 114 (suppl.), S31-S44 (1997).
    • (1997) Parasitology , vol.114 , Issue.SUPPL.
    • Wang, C.C.1
  • 4
    • 9144235678 scopus 로고    scopus 로고
    • A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei
    • Mackey, Z.B., O'Brien, T.C., Greenbaum, D.C., Blank, R.B. & McKerrow, J.H. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J. Biol. Chem. 279, 48426-48433 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 48426-48433
    • Mackey, Z.B.1    O'Brien, T.C.2    Greenbaum, D.C.3    Blank, R.B.4    McKerrow, J.H.5
  • 5
    • 0034054576 scopus 로고    scopus 로고
    • Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
    • Bogyo, M., Verhelst, S., Bellingard-Dubouchaud, V., Toba, S. & Greenbaum, D. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem. Biol. 7, 27-38 (2000).
    • (2000) Chem. Biol. , vol.7 , pp. 27-38
    • Bogyo, M.1    Verhelst, S.2    Bellingard-Dubouchaud, V.3    Toba, S.4    Greenbaum, D.5
  • 6
    • 24944497371 scopus 로고    scopus 로고
    • Features of selective kinase inhibitors
    • Knight, Z.A. & Shokat, K.M. Features of selective kinase inhibitors. Chem. Biol. 12, 621-637 (2005).
    • (2005) Chem. Biol. , vol.12 , pp. 621-637
    • Knight, Z.A.1    Shokat, K.M.2
  • 7
    • 0031937742 scopus 로고    scopus 로고
    • Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi
    • Engel, J.C. et al. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J. Cell Sci. 111, 597-606 (1998).
    • (1998) J. Cell Sci. , vol.111 , pp. 597-606
    • Engel, J.C.1
  • 8
    • 0026671825 scopus 로고
    • Ornithine decarboxylase as an enzyme target for therapy
    • McCann, P.P. & Pegg, A.E. Ornithine decarboxylase as an enzyme target for therapy. Pharmacol. Ther. 54, 195-215 (1992).
    • (1992) Pharmacol. Ther. , vol.54 , pp. 195-215
    • McCann, P.P.1    Pegg, A.E.2
  • 9
    • 85029183455 scopus 로고    scopus 로고
    • Reversed amidines and methods of using them for treating, preventing, or inhibiting leishmaniasis
    • WO patent application 2002/036588
    • Werbovetz, K.A., Brendle, J.J., Boykin, D.W. & Stephens, C.E. Reversed amidines and methods of using them for treating, preventing, or inhibiting leishmaniasis. WO patent application 2002/036588 (2002).
    • (2002)
    • Werbovetz, K.A.1    Brendle, J.J.2    Boykin, D.W.3    Stephens, C.E.4
  • 10
    • 85029167299 scopus 로고    scopus 로고
    • Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments
    • WO patent application 2002070467
    • Aschenbrenner, A. et al. Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments. WO patent application 2002070467 (2002).
    • (2002)
    • Aschenbrenner, A.1
  • 11
    • 85029149012 scopus 로고    scopus 로고
    • Preparation of N-amidinophenyl-N′-sulfamoylphenylureas and related compounds for the treatment of protozoal diseases and as inhibitors of intracellular protein degradation pathways
    • US patent application 2003119876
    • Aschenbrenner, A. et al. Preparation of N-amidinophenyl-N′- sulfamoylphenylureas and related compounds for the treatment of protozoal diseases and as inhibitors of intracellular protein degradation pathways. US patent application 2003119876 (2003).
    • (2003)
    • Aschenbrenner, A.1
  • 12
    • 33751084430 scopus 로고    scopus 로고
    • Cationic substituted benzofurans as antimicrobial agents
    • WO patent application 2005/055935
    • Werbovetz, K., Franzblau, S.G., Tidwell, R.R., Bakunova, S. & Bakunov, S. Cationic substituted benzofurans as antimicrobial agents. WO patent application 2005/055935 (2005).
    • (2005)
    • Werbovetz, K.1    Franzblau, S.G.2    Tidwell, R.R.3    Bakunova, S.4    Bakunov, S.5
  • 13
    • 85029162266 scopus 로고    scopus 로고
    • Preparation of novel amidines for treating microbial infections like human African trypanosomiasis and falciparum malaria
    • WO patent application 2005/033065
    • Tidwell, R.R., Boykin, D., Brun, R., Stephens, C.E. & Kumar, A. Preparation of novel amidines for treating microbial infections like human African trypanosomiasis and falciparum malaria. WO patent application 2005/033065 (2005).
    • (2005)
    • Tidwell, R.R.1    Boykin, D.2    Brun, R.3    Stephens, C.E.4    Kumar, A.5
  • 14
    • 85029147987 scopus 로고    scopus 로고
    • Preparation of dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
    • WO patent application 2004/050018
    • Boykin, D.W., Tidwell, R.R., Ismail, M.A. & Brun, R. Preparation of dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents. WO patent application 2004/050018 (2004).
    • (2004)
    • Boykin, D.W.1    Tidwell, R.R.2    Ismail, M.A.3    Brun, R.4
  • 15
    • 85029144871 scopus 로고    scopus 로고
    • Preparation of fused ring dicationic antiprotozoals and prodrugs thereof
    • WO patent application 2005/051296
    • Boykin, D.W. et al. Preparation of fused ring dicationic antiprotozoals and prodrugs thereof. WO patent application 2005/051296 (2005).
    • (2005)
    • Boykin, D.W.1
  • 16
    • 0036171856 scopus 로고    scopus 로고
    • Antileishmanial activities of several classes of aromatic dications
    • Brendle, J.J. et al. Antileishmanial activities of several classes of aromatic dications. Antimicrob. Agents Chemother. 46, 797-807 (2002).
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 797-807
    • Brendle, J.J.1
  • 17
    • 33644980902 scopus 로고    scopus 로고
    • 3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity
    • Athri, P. et al. 3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity. Bioorg. Med. Chem. 14, 3144-3152 (2006).
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 3144-3152
    • Athri, P.1
  • 18
    • 33745122945 scopus 로고    scopus 로고
    • DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity
    • Dardonville, C. et al. DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. J. Med. Chem. 49, 3748-3752 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 3748-3752
    • Dardonville, C.1
  • 20
    • 2342614821 scopus 로고    scopus 로고
    • Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities
    • Mayence, A. et al. Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J. Med. Chem. 47, 2700-2705 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 2700-2705
    • Mayence, A.1
  • 21
    • 0033598329 scopus 로고    scopus 로고
    • Prodrugs for amidines: Synthesis and anti-Pneumocystis carinii activity of aarbamates of 2,5-bis(4-amidinophenyl)furan
    • Rahmathullah, S.M. et al. Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of aarbamates of 2,5-bis(4-amidinophenyl) furan. J. Med. Chem. 42, 3994-4000 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 3994-4000
    • Rahmathullah, S.M.1
  • 22
    • 0036845742 scopus 로고    scopus 로고
    • Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl) furan across Caco-2 cell monolayers via its methylamidoidme prodrug
    • Zhou, L. et al. Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharm. Res. 19, 1689-1695 (2002).
    • (2002) Pharm. Res. , vol.19 , pp. 1689-1695
    • Zhou, L.1
  • 23
    • 3242663162 scopus 로고    scopus 로고
    • Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue
    • Sturk, L.M., Brock, J.L., Bagnell, C.R., Hall, J.E. & Tidwell, R.R. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop. 91, 131-143 (2004).
    • (2004) Acta Trop. , vol.91 , pp. 131-143
    • Sturk, L.M.1    Brock, J.L.2    Bagnell, C.R.3    Hall, J.E.4    Tidwell, R.R.5
  • 24
    • 17544387144 scopus 로고    scopus 로고
    • Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries
    • Berman, J.D. et al. Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries. Bull. World Health Organ. 76, 25-32 (1998).
    • (1998) Bull. World Health Organ. , vol.76 , pp. 25-32
    • Berman, J.D.1
  • 25
    • 17844382393 scopus 로고    scopus 로고
    • Liposomal amphotericin B: Clinical experience and perspectives
    • Gibbs, W.J., Drew, R.H. & Perfect, J.R. Liposomal amphotericin B: clinical experience and perspectives. Expert Rev. Anti Infect. Ther. 3, 167-181 (2005).
    • (2005) Expert Rev. Anti Infect. Ther. , vol.3 , pp. 167-181
    • Gibbs, W.J.1    Drew, R.H.2    Perfect, J.R.3
  • 26
    • 0025361947 scopus 로고
    • Dihydrofolate reductase as a therapeutic target
    • Schweitzer, B.I., Dicker, A.P. & Bertino, J.R. Dihydrofolate reductase as a therapeutic target. FASEB J. 4, 2441-2452 (1990).
    • (1990) FASEB J. , vol.4 , pp. 2441-2452
    • Schweitzer, B.I.1    Dicker, A.P.2    Bertino, J.R.3
  • 27
    • 0025409320 scopus 로고
    • Thymidylate synthase-dihydrofolate reductase in protozoa
    • Ivanetich, K.M. & Santi, D.V. Thymidylate synthase-dihydrofolate reductase in protozoa. Exp. Parasitol. 70, 367-371 (1990).
    • (1990) Exp. Parasitol. , vol.70 , pp. 367-371
    • Ivanetich, K.M.1    Santi, D.V.2
  • 28
    • 0028403267 scopus 로고
    • Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase
    • Knighton, D.R. et al. Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase. Nat. Struct. Biol. 1, 186-194 (1994).
    • (1994) Nat. Struct. Biol. , vol.1 , pp. 186-194
    • Knighton, D.R.1
  • 29
    • 0033577778 scopus 로고    scopus 로고
    • The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase
    • Zuccotto, F., Brun, R., Gonzalez Pacanowska, D., Ruiz Perez, L.M. & Gilbert, I.H. The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg. Med. Chem. Lett. 9, 1463-1468 (1999).
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 1463-1468
    • Zuccotto, F.1    Brun, R.2    Gonzalez Pacanowska, D.3    Ruiz Perez, L.M.4    Gilbert, I.H.5
  • 30
    • 0035329232 scopus 로고    scopus 로고
    • Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
    • Zuccotto, F. et al. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase. Eur. J. Med. Chem. 36, 395-405 (2001).
    • (2001) Eur. J. Med. Chem. , vol.36 , pp. 395-405
    • Zuccotto, F.1
  • 31
    • 0035938353 scopus 로고    scopus 로고
    • Novel inhibitors of leishmanial dihydrofolate reductase
    • Chowdhury, S.F. et al. Novel inhibitors of leishmanial dihydrofolate reductase. Bioorg. Med. Chem. Lett. 11, 977-980 (2001).
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 977-980
    • Chowdhury, S.F.1
  • 32
    • 0037130297 scopus 로고    scopus 로고
    • Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes
    • Gilbert, I.H. Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes. Biochim. Biophys. Acta 1587, 249-257 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 249-257
    • Gilbert, I.H.1
  • 33
    • 0030946111 scopus 로고    scopus 로고
    • The roles of pteridine reductase 1 and dihydrofolate reductase- thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
    • Nare, B., Hardy, L.W. & Beverley, S.M. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J. Biol. Chem. 272, 13883-13891 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 13883-13891
    • Nare, B.1    Hardy, L.W.2    Beverley, S.M.3
  • 34
    • 0023706778 scopus 로고
    • Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines
    • Sirawaraporn, W. et al. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines. Mol. Biochem. Parasitol. 31, 79-85 (1988).
    • (1988) Mol. Biochem. Parasitol. , vol.31 , pp. 79-85
    • Sirawaraporn, W.1
  • 35
    • 0032749527 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase
    • Chowdhury, S.F. et al. Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J. Med. Chem. 42, 4300-4312 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 4300-4312
    • Chowdhury, S.F.1
  • 36
    • 10744224199 scopus 로고    scopus 로고
    • 2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase
    • Pez, D. et al. 2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Bioorg. Med. Chem. 11, 4693-4711 (2003).
    • (2003) Bioorg. Med. Chem. , vol.11 , pp. 4693-4711
    • Pez, D.1
  • 38
    • 1642493673 scopus 로고    scopus 로고
    • Induced fit, drug design, and dUTPase
    • Stout, C.D. Induced fit, drug design, and dUTPase. Structure 12, 2-3 (2004).
    • (2004) Structure , vol.12 , pp. 2-3
    • Stout, C.D.1
  • 39
    • 13844296398 scopus 로고    scopus 로고
    • dUTPase as a platform for antimalarial drug design: Structural basis for the selectivity of a class of nucleoside inhibitors
    • Whittingham, J.L. et al. dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. Structure 13, 329-338 (2005).
    • (2005) Structure , vol.13 , pp. 329-338
    • Whittingham, J.L.1
  • 40
    • 0035933201 scopus 로고    scopus 로고
    • Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness
    • Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc. Natl. Acad. Sci. USA 98, 6412-6416 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6412-6416
    • Hofer, A.1    Steverding, D.2    Chabes, A.3    Brun, R.4    Thelander, L.5
  • 41
    • 0036178381 scopus 로고    scopus 로고
    • Review: Cysteine proteases of parasitic organisms
    • Sajid, M. & McKerrow, J.H. Review: cysteine proteases of parasitic organisms. Mol. Biochem. Parasitol. 120, 1-21 (2002).
    • (2002) Mol. Biochem. Parasitol. , vol.120 , pp. 1-21
    • Sajid, M.1    McKerrow, J.H.2
  • 42
    • 0031691453 scopus 로고    scopus 로고
    • Antimalarial synergy of cysteine and aspartic protease inhibitors
    • Semenov, A., Olson, J.E. & Rosenthal, P.J. Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob. Agents Chemother. 42, 2254-2258 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2254-2258
    • Semenov, A.1    Olson, J.E.2    Rosenthal, P.J.3
  • 43
    • 0035997361 scopus 로고    scopus 로고
    • Biological roles of proteases in parasitic protozoa
    • Klemba, M. & Goldberg, D.E. Biological roles of proteases in parasitic protozoa. Annu. Rev. Biochem. 71, 275-305 (2002).
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 275-305
    • Klemba, M.1    Goldberg, D.E.2
  • 44
    • 85029171281 scopus 로고    scopus 로고
    • Thiosemicarbazones and other compounds as antiparasitic compounds, their preparation, and methods of their use
    • WO patent application 2005/087211
    • Chibale, K., Greenbaum, D.C. & McKerrow, J.H. Thiosemicarbazones and other compounds as antiparasitic compounds, their preparation, and methods of their use. WO patent application 2005/087211 (2005).
    • (2005)
    • Chibale, K.1    Greenbaum, D.C.2    McKerrow, J.H.3
  • 45
    • 0037142343 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
    • Du, X. et al. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J. Med. Chem. 45, 2695-2707 (2002).
    • (2002) J. Med. Chem. , vol.45 , pp. 2695-2707
    • Du, X.1
  • 46
    • 13044256387 scopus 로고    scopus 로고
    • Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
    • Selzer, P.M. et al. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc. Natl. Acad. Sci. USA 96, 11015-11022 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11015-11022
    • Selzer, P.M.1
  • 47
    • 77952147853 scopus 로고    scopus 로고
    • Schistosomiasis mansoni: Novel chemotherapy using a cysteine protease inhibitor
    • (in the press)
    • Abdulla, M.-H., Lim, K.C., Sajid, M., McKerrow, J.H. & Caffrey, C.R. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. (in the press).
    • PLoS Med.
    • Abdulla, M.-H.1    Lim, K.C.2    Sajid, M.3    McKerrow, J.H.4    Caffrey, C.R.5
  • 48
    • 0028866134 scopus 로고
    • The mechanisms of Trypanosoma cruzi invasion of mammalian cells
    • Burleigh, B.A. & Andrews, N.W. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu. Rev. Microbiol. 49, 175-200 (1995).
    • (1995) Annu. Rev. Microbiol. , vol.49 , pp. 175-200
    • Burleigh, B.A.1    Andrews, N.W.2
  • 49
    • 0037025351 scopus 로고    scopus 로고
    • Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes
    • Salter, J.P. et al. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J. Biol. Chem. 277, 24618-24624 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 24618-24624
    • Salter, J.P.1
  • 50
    • 0033527572 scopus 로고    scopus 로고
    • Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
    • Eggleson, K.K., Duffin, K.L. & Goldberg, D.E. Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum. J. Biol. Chem. 274, 32411-32417 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 32411-32417
    • Eggleson, K.K.1    Duffin, K.L.2    Goldberg, D.E.3
  • 51
    • 33746748754 scopus 로고    scopus 로고
    • Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum
    • Madrid, P.B., Liou, A.P., DeRisi, J.L. & Guy, R.K. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. J. Med. Chem. 49, 4535-4543 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 4535-4543
    • Madrid, P.B.1    Liou, A.P.2    DeRisi, J.L.3    Guy, R.K.4
  • 52
    • 85029164584 scopus 로고    scopus 로고
    • Chloroquine analogs, their preparation, and methods of preventing and treating plasmodial disease
    • WO patent application 96/40138
    • Krogstad, D.J. & De, D. Chloroquine analogs, their preparation, and methods of preventing and treating plasmodial disease. WO patent application 96/40138 (1996).
    • (1996)
    • Krogstad, D.J.1    De, D.2
  • 53
    • 0032481004 scopus 로고    scopus 로고
    • Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines
    • De, D., Krogstad, F.M., Byers, L.D. & Krogstad, D.J. Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines. J. Med. Chem. 41, 4918-4926 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 4918-4926
    • De, D.1    Krogstad, F.M.2    Byers, L.D.3    Krogstad, D.J.4
  • 54
    • 16544371153 scopus 로고    scopus 로고
    • Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques
    • Ramanathan-Girish, S. et al. Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques. Int. J. Toxicol. 23, 179-189 (2004).
    • (2004) Int. J. Toxicol. , vol.23 , pp. 179-189
    • Ramanathan-Girish, S.1
  • 55
    • 85029175324 scopus 로고    scopus 로고
    • Preparation of anilino-quninolines as anti-malarial compounds
    • WO patent application 2002/072554
    • Park, B.K., O'Neill, P.M., Ward, S.A. & Stocks, P.A. Preparation of anilino-quninolines as anti-malarial compounds. WO patent application 2002/072554 (2002).
    • (2002)
    • Park, B.K.1    O'Neill, P.M.2    Ward, S.A.3    Stocks, P.A.4
  • 56
    • 85029163482 scopus 로고    scopus 로고
    • Ring-substituted 8-aminoquinoline analogs as antimalarial agents and process for their preparation
    • WO patent application 2004/085402
    • Jain, R. et al. Ring-substituted 8-aminoquinoline analogs as antimalarial agents and process for their preparation. WO patent application 2004/085402 (2004).
    • (2004)
    • Jain, R.1
  • 57
    • 85029158062 scopus 로고    scopus 로고
    • Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1, 4-pentanediamine as gametocytocidal agent
    • US patent application 2003199697
    • Pratap, R. et al. Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8- quinolinyl)-1,4-pentanediamine as gametocytocidal agent. US patent application 2003199697 (2003).
    • (2003)
    • Pratap, R.1
  • 58
    • 85029179194 scopus 로고    scopus 로고
    • Preparation of quinolizidinylalkylaminoquinolines as antimalarials
    • WO patent application 2005/037833
    • Sparatore, A. et al. Preparation of quinolizidinylalkylaminoquinolines as antimalarials. WO patent application 2005/037833 (2005).
    • (2005)
    • Sparatore, A.1
  • 59
    • 85029147797 scopus 로고    scopus 로고
    • Preparation of compounds which contain a 1,2,4-trioxane moiety linked to a quinoline moiety for pharmaceutical use as antimalarial agents
    • WO patent application 2001/077105
    • Meunier, B., Robert, A., Dechy-Cabaret, O. & Benoit-Vical, F. Preparation of compounds which contain a 1,2,4-trioxane moiety linked to a quinoline moiety for pharmaceutical use as antimalarial agents. WO patent application 2001/077105 (2001).
    • (2001)
    • Meunier, B.1    Robert, A.2    Dechy-Cabaret, O.3    Benoit-Vical, F.4
  • 60
    • 33745468499 scopus 로고    scopus 로고
    • Medicines for Malaria Venture: Sustaining antimalarial drug development
    • Bathurst, I. & Hentschel, C. Medicines for Malaria Venture: sustaining antimalarial drug development. Trends Parasitol. 22, 301-307 (2006).
    • (2006) Trends Parasitol. , vol.22 , pp. 301-307
    • Bathurst, I.1    Hentschel, C.2
  • 61
    • 2942666622 scopus 로고    scopus 로고
    • Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity
    • Haynes, R.K. et al. Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity. Angew. Chem. Int. Edn. Engl. 43, 1381-1385 (2004).
    • (2004) Angew. Chem. Int. Edn. Engl. , vol.43 , pp. 1381-1385
    • Haynes, R.K.1
  • 62
    • 0001123285 scopus 로고    scopus 로고
    • Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action
    • Cumming, J.N., Ploypradith, P. & Posner, G.H. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Adv. Pharmacol. 37, 253-297 (1997).
    • (1997) Adv. Pharmacol. , vol.37 , pp. 253-297
    • Cumming, J.N.1    Ploypradith, P.2    Posner, G.H.3
  • 63
    • 0036001107 scopus 로고    scopus 로고
    • How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view
    • Wu, Y. How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view. Acc. Chem. Res. 35, 255-259 (2002).
    • (2002) Acc. Chem. Res. , vol.35 , pp. 255-259
    • Wu, Y.1
  • 64
    • 7944222115 scopus 로고    scopus 로고
    • Artemisinins: Mechanisms of action and potential for resistance
    • Krishna, S., Uhlemann, A.-C. & Haynes, R.K. Artemisinins: mechanisms of action and potential for resistance. Drug Resist. Updat. 7, 233-244 (2004).
    • (2004) Drug Resist. Updat. , vol.7 , pp. 233-244
    • Krishna, S.1    Uhlemann, A.-C.2    Haynes, R.K.3
  • 65
    • 0042860063 scopus 로고    scopus 로고
    • Artemisinins target the SERCA of Plasmodium falciparum
    • Eckstein-Ludwig, U. et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424, 957-961 (2003).
    • (2003) Nature , vol.424 , pp. 957-961
    • Eckstein-Ludwig, U.1
  • 66
    • 27744592680 scopus 로고    scopus 로고
    • Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: Implications for the molecular mechanism of action of the artemisinins
    • O'Neill, P.M. et al. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. ChemBioChem 6, 2048-2054 (2005).
    • (2005) ChemBioChem , vol.6 , pp. 2048-2054
    • O'Neill, P.M.1
  • 67
    • 2542640961 scopus 로고    scopus 로고
    • A medicinal chemistry perspective on artemisinin and related endoperoxides
    • O'Neill, P.M. & Posner, G.H. A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 47, 2945-2964 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 2945-2964
    • O'Neill, P.M.1    Posner, G.H.2
  • 68
    • 21044434332 scopus 로고    scopus 로고
    • Convenient access both to highly antimalaria-active 10- arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate
    • Haynes, R.K. et al. Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate. ChemBioChem 6, 659-667 (2005).
    • (2005) ChemBioChem , vol.6 , pp. 659-667
    • Haynes, R.K.1
  • 69
    • 85029176171 scopus 로고    scopus 로고
    • Preparation of artemisinin derivatives for treating malaria, neosporosis and coccidiosis
    • European patent application 974354
    • Haynes, R.K., Lam, W.-L., Chan, H.-W. & Tsang, H.-W. Preparation of artemisinin derivatives for treating malaria, neosporosis and coccidiosis. European patent application 974354 (2000).
    • (2000)
    • Haynes, R.K.1    Lam, W.-L.2    Chan, H.-W.3    Tsang, H.-W.4
  • 70
    • 85029178843 scopus 로고    scopus 로고
    • Preparation of dihydroartemisinin derivatives as antimalarial and antitumor agents
    • WO patent application 2003/048167
    • O'Neill, P.M., Higson, A.P., Taylor, S. & Irving, E. Preparation of dihydroartemisinin derivatives as antimalarial and antitumor agents. WO patent application 2003/048167 (2003).
    • (2003)
    • O'Neill, P.M.1    Higson, A.P.2    Taylor, S.3    Irving, E.4
  • 71
    • 0032962098 scopus 로고    scopus 로고
    • Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family
    • Posner, G.H. et al. Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family. J. Med. Chem. 42, 300-304 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 300-304
    • Posner, G.H.1
  • 72
    • 0033619978 scopus 로고    scopus 로고
    • Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether
    • O'Neill, P.M. et al. Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. J. Med. Chem. 42, 5487-5493 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 5487-5493
    • O'Neill, P.M.1
  • 73
    • 85029155797 scopus 로고    scopus 로고
    • Preparation of novel artemisinin derivatives and their use for treating malaria
    • WO patent application 2003/035651
    • Begue, J.-P. et al. Preparation of novel artemisinin derivatives and their use for treating malaria. WO patent application 2003/035651 (2003).
    • (2003)
    • Begue, J.-P.1
  • 74
    • 0037186497 scopus 로고    scopus 로고
    • Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues
    • Hindley, S. et al. Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. J. Med. Chem. 45, 1052-1063 (2002).
    • (2002) J. Med. Chem. , vol.45 , pp. 1052-1063
    • Hindley, S.1
  • 75
    • 85029149394 scopus 로고    scopus 로고
    • Preparation of orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high selectivity, stability and efficacy
    • WO patent application 2004/028476
    • Posner, G.H. et al. Preparation of orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high selectivity, stability and efficacy. WO patent application 2004/028476 (2004).
    • (2004)
    • Posner, G.H.1
  • 76
    • 85029178843 scopus 로고    scopus 로고
    • Preparation of dihydroartemisinin derivatives as antimalarial and anticancer agents
    • WO patent application 2003/048168
    • O'Neill, P.M., Higson, A.P., Taylor, S. & Irving, E. Preparation of dihydroartemisinin derivatives as antimalarial and anticancer agents. WO patent application 2003/048168 (2003).
    • (2003)
    • O'Neill, P.M.1    Higson, A.P.2    Taylor, S.3    Irving, E.4
  • 77
    • 85029160289 scopus 로고    scopus 로고
    • Preparation of anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities
    • WO patent application 2006/002105
    • Mahmoud, A.E. & Waseem, G. Preparation of anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities. WO patent application 2006/002105 (2006).
    • (2006)
    • Mahmoud, A.E.1    Waseem, G.2
  • 78
    • 85029179233 scopus 로고    scopus 로고
    • Preparation of artemisinin derivatives as antiparasitic agents
    • European patent application 974593
    • Haynes, R.K. & Lam, W.-L. Preparation of artemisinin derivatives as antiparasitic agents. European patent application 974593 (2000).
    • (2000)
    • Haynes, R.K.1    Lam, W.-L.2
  • 79
    • 85029165805 scopus 로고    scopus 로고
    • Preparation of artemisinin-based peroxide compounds as broad spectrum anti-infective agents
    • WO patent application 2003/095444
    • Avery, M.A. & Muraleedharan, K.M. Preparation of artemisinin-based peroxide compounds as broad spectrum anti-infective agents. WO patent application 2003/095444 (2003).
    • (2003)
    • Avery, M.A.1    Muraleedharan, K.M.2
  • 80
    • 33751092100 scopus 로고    scopus 로고
    • Synthesis and antiparasitic activity of artemisinin derivatives (endoperoxides)
    • WO patent application 2000/004024
    • Haynes, R.K., Chan, H.-W., Lam, W.-L., Tsang, H.-W. & Cheung, M.-K. Synthesis and antiparasitic activity of artemisinin derivatives (endoperoxides). WO patent application 2000/004024 (2000).
    • (2000)
    • Haynes, R.K.1    Chan, H.-W.2    Lam, W.-L.3    Tsang, H.-W.4    Cheung, M.-K.5
  • 81
    • 33751071443 scopus 로고    scopus 로고
    • Preparation of antiparasitic artemisinin derivatives (sesquiterpene endoperoxides)
    • WO patent application 2003/076446
    • Haynes, R.K. Preparation of antiparasitic artemisinin derivatives (sesquiterpene endoperoxides). WO patent application 2003/076446 (2003).
    • (2003)
    • Haynes, R.K.1
  • 82
    • 33745975677 scopus 로고    scopus 로고
    • Artemisone - A highly active antimalarial drug of the artemisinin class
    • Haynes, R.K. et al. Artemisone - a highly active antimalarial drug of the artemisinin class. Angew. Chem. Int. Ed. 45, 2082-2088 (2006).
    • (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 2082-2088
    • Haynes, R.K.1
  • 83
    • 85029168030 scopus 로고    scopus 로고
    • Medicines for Malaria Venture
    • Medicines for Malaria Venture. Curing malaria together: annual report 2005. Medicines for Malaria Venture 〈http://www.mmv.org/IMG/pdf/ full_report.pdf〉 (2005).
    • (2005) Curing Malaria Together: Annual Report 2005
  • 84
    • 0032510451 scopus 로고    scopus 로고
    • Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation
    • Posner, G.H. et al. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. J. Med. Chem. 41, 940-951 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 940-951
    • Posner, G.H.1
  • 85
    • 33646459918 scopus 로고    scopus 로고
    • Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxa spiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice
    • Singh, C., Malik, H. & Puri, S.K. Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxa spiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice. J. Med. Chem. 49, 2794-2803 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 2794-2803
    • Singh, C.1    Malik, H.2    Puri, S.K.3
  • 86
    • 33745081807 scopus 로고    scopus 로고
    • Blood schizontocidal activity of selected 1,2,4-trioxanes (fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo
    • Tripathi, R., Jefford, C.W. & Dutta, G.P. Blood schizontocidal activity of selected 1,2,4-trioxanes (fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo. Parasitology 133, 1-9 (2006).
    • (2006) Parasitology , vol.133 , pp. 1-9
    • Tripathi, R.1    Jefford, C.W.2    Dutta, G.P.3
  • 87
    • 33751120002 scopus 로고    scopus 로고
    • Preparation of spiro/dispiro-1,2,4-trioxolanes as antimalarial agents
    • US patent 6,486,199
    • Vennerstrom, J.L., Dong, Y., Chollet, J. & Matile, H. Preparation of spiro/dispiro-1,2,4-trioxolanes as antimalarial agents. US patent 6,486,199 (2002).
    • (2002)
    • Vennerstrom, J.L.1    Dong, Y.2    Chollet, J.3    Matile, H.4
  • 88
    • 85029175125 scopus 로고    scopus 로고
    • Preparation of spiro- and dispiro-1,2,4-trioxolanes as antimalarial agents, schistosomicides, and anticancer agents
    • US patent application 2004039008
    • Vennerstrom, J.L. et al. Preparation of spiro- and dispiro-1,2,4- trioxolanes as antimalarial agents, schistosomicides, and anticancer agents. US patent application 2004039008 (2004).
    • (2004)
    • Vennerstrom, J.L.1
  • 89
    • 4344630762 scopus 로고    scopus 로고
    • Identification of an antimalarial synthetic trioxolane drug development candidate
    • Vennerstrom, J.L. et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430, 900-904 (2004).
    • (2004) Nature , vol.430 , pp. 900-904
    • Vennerstrom, J.L.1
  • 90
    • 22744432838 scopus 로고    scopus 로고
    • Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes
    • Dong, Y. et al. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J. Med. Chem. 48, 4953-4961 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 4953-4961
    • Dong, Y.1
  • 91
    • 18744417592 scopus 로고    scopus 로고
    • Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: Alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes
    • Vennerstrom, J.L. et al. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes. J. Med. Chem. 43, 2753-2758 (2000).
    • (2000) J. Med. Chem. , vol.43 , pp. 2753-2758
    • Vennerstrom, J.L.1
  • 92
    • 0035811454 scopus 로고    scopus 로고
    • Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
    • Kim, H.S. et al. Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes. J. Med. Chem. 44, 2357-2361 (2001).
    • (2001) J. Med. Chem. , vol.44 , pp. 2357-2361
    • Kim, H.S.1
  • 93
    • 0032482445 scopus 로고    scopus 로고
    • Antimalarial cyclic peroxy ketals
    • Posner, G.H. et al. Antimalarial cyclic peroxy ketals. J. Med. Chem. 41, 2164-2167 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 2164-2167
    • Posner, G.H.1
  • 94
    • 0028170770 scopus 로고
    • Ro 42-1611 (arteflene), a new effective antimalarial: Chemical structure and biological activity
    • Hofheinz, W. et al. Ro 42-1611 (arteflene), a new effective antimalarial: chemical structure and biological activity. Trop. Med. Parasitol. 45, 261-265 (1994).
    • (1994) Trop. Med. Parasitol. , vol.45 , pp. 261-265
    • Hofheinz, W.1
  • 95
    • 0038440391 scopus 로고    scopus 로고
    • A short synthesis and biological evaluation of potent and non-toxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides
    • Bachi, M.D. et al. A short synthesis and biological evaluation of potent and non-toxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides. J. Med. Chem. 46, 2516-2533 (2003).
    • (2003) J. Med. Chem. , vol.46 , pp. 2516-2533
    • Bachi, M.D.1
  • 96
    • 4544263432 scopus 로고    scopus 로고
    • Design and synthesis of endoperoxide antimalarial prodrug models
    • O'Neill, P.M. et al. Design and synthesis of endoperoxide antimalarial prodrug models. Angew. Chem. Int. Ed. 43, 4193-4197 (2004).
    • (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 4193-4197
    • O'Neill, P.M.1
  • 97
    • 0032510451 scopus 로고    scopus 로고
    • Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation
    • Posner, G.H. et al. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. J. Med. Chem. 41, 940-951 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 940-951
    • Posner, G.H.1
  • 98
    • 85029188902 scopus 로고    scopus 로고
    • Synthesis and activity of water-soluble trioxanes as potent and safe antimalarial agents
    • WO patent application 2000/059501
    • Posner, G.H., Parker, M.H., Krasavin, M. & Shapiro, T.A. Synthesis and activity of water-soluble trioxanes as potent and safe antimalarial agents. WO patent application 2000/059501 (2000).
    • (2000)
    • Posner, G.H.1    Parker, M.H.2    Krasavin, M.3    Shapiro, T.A.4
  • 99
    • 33845363105 scopus 로고    scopus 로고
    • Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof
    • WO patent application 2003082852
    • Singh, C., Tiwari, P. & Puri, S.K. Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof. WO patent application 2003082852 (2003).
    • (2003)
    • Singh, C.1    Tiwari, P.2    Puri, S.K.3
  • 100
    • 85029169464 scopus 로고    scopus 로고
    • 1,2,4-Trioxanes and 1,2,4-trioxepanes useful as antimalarial and anticancer agents, and their pharmaceutical compositions, use, and preparation via the thiol-olefin co-oxygenation (TOCO) reaction
    • US patent application 2005256184
    • O'Neill, P.M., Amewu, R., Mukhtar, A. & Ward, S.A. 1,2,4-Trioxanes and 1,2,4-trioxepanes useful as antimalarial and anticancer agents, and their pharmaceutical compositions, use, and preparation via the thiol-olefin co-oxygenation (TOCO) reaction. US patent application 2005256184 (2005).
    • (2005)
    • O'Neill, P.M.1    Amewu, R.2    Mukhtar, A.3    Ward, S.A.4
  • 101
    • 17744377209 scopus 로고    scopus 로고
    • Total syntheses of yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities
    • Szpilman, A.M., Korshin, E.E., Rozenberg, H. & Bachi, M.D. Total syntheses of yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities. J. Org. Chem. 70, 3618-3632 (2005).
    • (2005) J. Org. Chem. , vol.70 , pp. 3618-3632
    • Szpilman, A.M.1    Korshin, E.E.2    Rozenberg, H.3    Bachi, M.D.4
  • 102
    • 67849104407 scopus 로고    scopus 로고
    • Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis
    • US patent application 2005256185
    • Vennerstrom, J.L. et al. Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis. US patent application 2005256185 (2005).
    • (2005)
    • Vennerstrom, J.L.1
  • 103
    • 33748767111 scopus 로고    scopus 로고
    • Therapeutic intervention based on protein prenylation and associated modifications
    • Gelb, M.H. et al. Therapeutic intervention based on protein prenylation and associated modifications. Nat. Chem. Biol. 2, 518-528 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 518-528
    • Gelb, M.H.1
  • 105
    • 0030865773 scopus 로고    scopus 로고
    • Ras farnesyltransferase: A new therapeutic target
    • Leonard, D.M. Ras farnesyltransferase: a new therapeutic target. J. Med. Chem. 40, 2971-2990 (1997).
    • (1997) J. Med. Chem. , vol.40 , pp. 2971-2990
    • Leonard, D.M.1
  • 107
    • 0345073644 scopus 로고    scopus 로고
    • Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
    • Gelb, M.H. et al. Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol. Biochem. Parasitol. 126, 155-163 (2003).
    • (2003) Mol. Biochem. Parasitol. , vol.126 , pp. 155-163
    • Gelb, M.H.1
  • 108
    • 20144373679 scopus 로고    scopus 로고
    • Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
    • Nallan, L. et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J. Med. Chem. 48, 3704-3713 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 3704-3713
    • Nallan, L.1
  • 109
    • 33748858487 scopus 로고    scopus 로고
    • Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites
    • Glenn, M.P. et al. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. J. Med. Chem. 49, 5710-5727 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 5710-5727
    • Glenn, M.P.1
  • 110
    • 0017366999 scopus 로고
    • Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: The glycosome
    • Opperdoes, F.R. & Borst, P. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett. 80, 360-364 (1977).
    • (1977) FEBS Lett. , vol.80 , pp. 360-364
    • Opperdoes, F.R.1    Borst, P.2
  • 111
    • 0030560864 scopus 로고    scopus 로고
    • Metabolic compartmentation in African trypanosomes
    • Clayton, C.E. & Michels, P. Metabolic compartmentation in African trypanosomes. Parasitol. Today 12, 465-471 (1996).
    • (1996) Parasitol. Today , vol.12 , pp. 465-471
    • Clayton, C.E.1    Michels, P.2
  • 112
    • 0035339822 scopus 로고    scopus 로고
    • Enzymes of carbohydrate metabolism as potential drug targets
    • Opperdoes, F.R. & Michels, P.A. Enzymes of carbohydrate metabolism as potential drug targets. Int. J. Parasitol. 31, 482-490 (2001).
    • (2001) Int. J. Parasitol. , vol.31 , pp. 482-490
    • Opperdoes, F.R.1    Michels, P.A.2
  • 113
    • 0035062226 scopus 로고    scopus 로고
    • Glycolysis as a target for the design of new anti-trypanosome drugs
    • Verlinde, C.L.M.J. et al. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist. Updat. 4, 50-65 (2001).
    • (2001) Drug Resist. Updat. , vol.4 , pp. 50-65
    • Verlinde, C.L.M.J.1
  • 114
    • 1642335814 scopus 로고    scopus 로고
    • History of the development of azole derivatives
    • Maertens, J.A. History of the development of azole derivatives. Clin. Microbiol. Infect. 10 (suppl.), 1-10 (2004).
    • (2004) Clin. Microbiol. Infect. , vol.10 , Issue.SUPPL. , pp. 1-10
    • Maertens, J.A.1
  • 115
    • 16244416503 scopus 로고    scopus 로고
    • Second-generation azole antifungal agents
    • Kale, P. & Johnson, L.B. Second-generation azole antifungal agents. Drugs Today (Barc) 41, 91-105 (2005).
    • (2005) Drugs Today (Barc) , vol.41 , pp. 91-105
    • Kale, P.1    Johnson, L.B.2
  • 116
    • 17944384088 scopus 로고    scopus 로고
    • Treatment of chronic Chagas' disease with itraconazole and allopurinol
    • Apt, W. et al. Treatment of chronic Chagas' disease with itraconazole and allopurinol. Am. J. Trop. Med. Hyg. 59, 133-138 (1998).
    • (1998) Am. J. Trop. Med. Hyg. , vol.59 , pp. 133-138
    • Apt, W.1
  • 117
    • 0024235435 scopus 로고
    • Failure of ketoconazole to cure chronic murine Chagas' disease
    • McCabe, R. Failure of ketoconazole to cure chronic murine Chagas' disease. J. Infect. Dis. 158, 1408-1409 (1988).
    • (1988) J. Infect. Dis. , vol.158 , pp. 1408-1409
    • McCabe, R.1
  • 118
    • 0027484860 scopus 로고
    • An experimental and clinical assay with ketoconazole in the treatment of Chagas disease
    • Brener, Z. et al. An experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Mem. Inst. Oswaldo Cruz 88, 149-153 (1993).
    • (1993) Mem. Inst. Oswaldo Cruz , vol.88 , pp. 149-153
    • Brener, Z.1
  • 119
    • 7244219956 scopus 로고    scopus 로고
    • Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts
    • Guedes, P.M. et al. Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Antimicrob. Agents Chemother. 48, 4286-4292 (2004).
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 4286-4292
    • Guedes, P.M.1
  • 121
    • 25844444087 scopus 로고    scopus 로고
    • Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors
    • Hankins, E.G., Gillespie, J.R., Aikenhead, K. & Buckner, F.S. Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol. Biochem. Parasitol. 144, 68-75 (2005).
    • (2005) Mol. Biochem. Parasitol. , vol.144 , pp. 68-75
    • Hankins, E.G.1    Gillespie, J.R.2    Aikenhead, K.3    Buckner, F.S.4
  • 122
    • 0031807492 scopus 로고    scopus 로고
    • Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
    • Urbina, J.A. et al. Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob. Agents Chemother. 42, 1771-1777 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1771-1777
    • Urbina, J.A.1
  • 123
    • 0033987127 scopus 로고    scopus 로고
    • Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts
    • Molina, J. et al. Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Antimicrob. Agents Chemother. 44, 150-155 (2000).
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 150-155
    • Molina, J.1
  • 124
    • 29144480979 scopus 로고    scopus 로고
    • Protein kinases as drug targets in trypanosomes and Leishmania
    • Naula, C., Parsons, M. & Mottram, J.C. Protein kinases as drug targets in trypanosomes and Leishmania. Biochim. Biophys. Acta 1754, 151-159 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1754 , pp. 151-159
    • Naula, C.1    Parsons, M.2    Mottram, J.C.3
  • 125
    • 1542315532 scopus 로고    scopus 로고
    • New ways with old bones. Osteoporosis researchers look for drugs to replace hormone replacement therapy
    • Bonn, D. New ways with old bones. Osteoporosis researchers look for drugs to replace hormone replacement therapy. Lancet 363, 786-787 (2004).
    • (2004) Lancet , vol.363 , pp. 786-787
    • Bonn, D.1
  • 126
    • 0037078250 scopus 로고    scopus 로고
    • Kwanzoquinones A-G and other constituents of Hemerocallis fulva 'Kwanzo' roots and their acivity against the human trematode parasite, Schistosoma mansoni
    • Cichewicz, R.H., Lim, K.C., McKerrow, J.H. & Nair, M.G. Kwanzoquinones A-G and other constituents of Hemerocallis fulva 'Kwanzo' roots and their acivity against the human trematode parasite, Schistosoma mansoni. Tetrahedron 58, 8597-8606 (2002).
    • (2002) Tetrahedron , vol.58 , pp. 8597-8606
    • Cichewicz, R.H.1    Lim, K.C.2    McKerrow, J.H.3    Nair, M.G.4
  • 127
    • 0035813213 scopus 로고    scopus 로고
    • Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel
    • Kohn, A.B., Anderson, P.A., Roberts-Misterly, J.M. & Greenberg, R.M. Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J. Biol. Chem. 276, 36873-36876 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 36873-36876
    • Kohn, A.B.1    Anderson, P.A.2    Roberts-Misterly, J.M.3    Greenberg, R.M.4
  • 128
    • 0030607410 scopus 로고    scopus 로고
    • Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo
    • Wasilewski, M.M., Lim, K.C., Phillips, J. & McKerrow, J.H. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol. Biochem. Parasitol. 81, 179-189 (1996).
    • (1996) Mol. Biochem. Parasitol. , vol.81 , pp. 179-189
    • Wasilewski, M.M.1    Lim, K.C.2    Phillips, J.3    McKerrow, J.H.4
  • 129
    • 33745199861 scopus 로고    scopus 로고
    • Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei
    • Mackey, Z.B. et al. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem. Biol. Drug Des. 67, 355-363 (2006).
    • (2006) Chem. Biol. Drug Des. , vol.67 , pp. 355-363
    • Mackey, Z.B.1
  • 131
    • 33746169858 scopus 로고    scopus 로고
    • Searching for new antimalarial therapeutics amongst known drugs
    • Weisman, J.L. et al. Searching for new antimalarial therapeutics amongst known drugs. Chem. Biol. Drug Des. 67, 409-416 (2006).
    • (2006) Chem. Biol. Drug Des. , vol.67 , pp. 409-416
    • Weisman, J.L.1
  • 132
    • 33746381549 scopus 로고    scopus 로고
    • A clinical drug library screen identifies astemizole as an antimalarial agent
    • Chong, C.R., Chen, X., Shi, L., Liu, J.O. & Sullivan, D.J. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat. Chem. Biol. 2, 415-416 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 415-416
    • Chong, C.R.1    Chen, X.2    Shi, L.3    Liu, J.O.4    Sullivan, D.J.5


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