-
1
-
-
33750518467
-
Designing drugs for parasitic diseases of the developing world
-
McKerrow, J.H. Designing drugs for parasitic diseases of the developing world. PLoS Med. 2, e210 (2005).
-
(2005)
PLoS Med.
, vol.2
-
-
McKerrow, J.H.1
-
2
-
-
0031024171
-
Experimenal and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A., Lombardo, F., Dominy, B.W. & Feeney, P.J. Experimenal and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3-25 (1997).
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
3
-
-
0030883947
-
Validating targets for antiparasite chemotherapy
-
Wang, C.C. Validating targets for antiparasite chemotherapy. Parasitology 114 (suppl.), S31-S44 (1997).
-
(1997)
Parasitology
, vol.114
, Issue.SUPPL.
-
-
Wang, C.C.1
-
4
-
-
9144235678
-
A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei
-
Mackey, Z.B., O'Brien, T.C., Greenbaum, D.C., Blank, R.B. & McKerrow, J.H. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J. Biol. Chem. 279, 48426-48433 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48426-48433
-
-
Mackey, Z.B.1
O'Brien, T.C.2
Greenbaum, D.C.3
Blank, R.B.4
McKerrow, J.H.5
-
5
-
-
0034054576
-
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
-
Bogyo, M., Verhelst, S., Bellingard-Dubouchaud, V., Toba, S. & Greenbaum, D. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem. Biol. 7, 27-38 (2000).
-
(2000)
Chem. Biol.
, vol.7
, pp. 27-38
-
-
Bogyo, M.1
Verhelst, S.2
Bellingard-Dubouchaud, V.3
Toba, S.4
Greenbaum, D.5
-
6
-
-
24944497371
-
Features of selective kinase inhibitors
-
Knight, Z.A. & Shokat, K.M. Features of selective kinase inhibitors. Chem. Biol. 12, 621-637 (2005).
-
(2005)
Chem. Biol.
, vol.12
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
7
-
-
0031937742
-
Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi
-
Engel, J.C. et al. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J. Cell Sci. 111, 597-606 (1998).
-
(1998)
J. Cell Sci.
, vol.111
, pp. 597-606
-
-
Engel, J.C.1
-
8
-
-
0026671825
-
Ornithine decarboxylase as an enzyme target for therapy
-
McCann, P.P. & Pegg, A.E. Ornithine decarboxylase as an enzyme target for therapy. Pharmacol. Ther. 54, 195-215 (1992).
-
(1992)
Pharmacol. Ther.
, vol.54
, pp. 195-215
-
-
McCann, P.P.1
Pegg, A.E.2
-
9
-
-
85029183455
-
Reversed amidines and methods of using them for treating, preventing, or inhibiting leishmaniasis
-
WO patent application 2002/036588
-
Werbovetz, K.A., Brendle, J.J., Boykin, D.W. & Stephens, C.E. Reversed amidines and methods of using them for treating, preventing, or inhibiting leishmaniasis. WO patent application 2002/036588 (2002).
-
(2002)
-
-
Werbovetz, K.A.1
Brendle, J.J.2
Boykin, D.W.3
Stephens, C.E.4
-
10
-
-
85029167299
-
Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments
-
WO patent application 2002070467
-
Aschenbrenner, A. et al. Derivatives of diphenylurea, diphenyloxalic acid diamide and diphenylsulfuric acid diamide and their use as medicaments. WO patent application 2002070467 (2002).
-
(2002)
-
-
Aschenbrenner, A.1
-
11
-
-
85029149012
-
Preparation of N-amidinophenyl-N′-sulfamoylphenylureas and related compounds for the treatment of protozoal diseases and as inhibitors of intracellular protein degradation pathways
-
US patent application 2003119876
-
Aschenbrenner, A. et al. Preparation of N-amidinophenyl-N′- sulfamoylphenylureas and related compounds for the treatment of protozoal diseases and as inhibitors of intracellular protein degradation pathways. US patent application 2003119876 (2003).
-
(2003)
-
-
Aschenbrenner, A.1
-
12
-
-
33751084430
-
Cationic substituted benzofurans as antimicrobial agents
-
WO patent application 2005/055935
-
Werbovetz, K., Franzblau, S.G., Tidwell, R.R., Bakunova, S. & Bakunov, S. Cationic substituted benzofurans as antimicrobial agents. WO patent application 2005/055935 (2005).
-
(2005)
-
-
Werbovetz, K.1
Franzblau, S.G.2
Tidwell, R.R.3
Bakunova, S.4
Bakunov, S.5
-
13
-
-
85029162266
-
Preparation of novel amidines for treating microbial infections like human African trypanosomiasis and falciparum malaria
-
WO patent application 2005/033065
-
Tidwell, R.R., Boykin, D., Brun, R., Stephens, C.E. & Kumar, A. Preparation of novel amidines for treating microbial infections like human African trypanosomiasis and falciparum malaria. WO patent application 2005/033065 (2005).
-
(2005)
-
-
Tidwell, R.R.1
Boykin, D.2
Brun, R.3
Stephens, C.E.4
Kumar, A.5
-
14
-
-
85029147987
-
Preparation of dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
-
WO patent application 2004/050018
-
Boykin, D.W., Tidwell, R.R., Ismail, M.A. & Brun, R. Preparation of dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents. WO patent application 2004/050018 (2004).
-
(2004)
-
-
Boykin, D.W.1
Tidwell, R.R.2
Ismail, M.A.3
Brun, R.4
-
15
-
-
85029144871
-
Preparation of fused ring dicationic antiprotozoals and prodrugs thereof
-
WO patent application 2005/051296
-
Boykin, D.W. et al. Preparation of fused ring dicationic antiprotozoals and prodrugs thereof. WO patent application 2005/051296 (2005).
-
(2005)
-
-
Boykin, D.W.1
-
16
-
-
0036171856
-
Antileishmanial activities of several classes of aromatic dications
-
Brendle, J.J. et al. Antileishmanial activities of several classes of aromatic dications. Antimicrob. Agents Chemother. 46, 797-807 (2002).
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 797-807
-
-
Brendle, J.J.1
-
17
-
-
33644980902
-
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity
-
Athri, P. et al. 3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity. Bioorg. Med. Chem. 14, 3144-3152 (2006).
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 3144-3152
-
-
Athri, P.1
-
18
-
-
33745122945
-
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity
-
Dardonville, C. et al. DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. J. Med. Chem. 49, 3748-3752 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3748-3752
-
-
Dardonville, C.1
-
19
-
-
0030591850
-
Anti-pneumocystis activity of bisamidoximes and bis-O-alkylamidoximes prodrugs
-
Boykin, D.W., Kumar, A., Hall, J.E., Bender, B.C. & Tidwell, R.R. Anti-pneumocystis activity of bisamidoximes and bis-O-alkylamidoximes prodrugs. Bioorg. Med. Chem. Lett. 6, 3017-3020 (1996).
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 3017-3020
-
-
Boykin, D.W.1
Kumar, A.2
Hall, J.E.3
Bender, B.C.4
Tidwell, R.R.5
-
20
-
-
2342614821
-
Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities
-
Mayence, A. et al. Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. J. Med. Chem. 47, 2700-2705 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2700-2705
-
-
Mayence, A.1
-
21
-
-
0033598329
-
Prodrugs for amidines: Synthesis and anti-Pneumocystis carinii activity of aarbamates of 2,5-bis(4-amidinophenyl)furan
-
Rahmathullah, S.M. et al. Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of aarbamates of 2,5-bis(4-amidinophenyl) furan. J. Med. Chem. 42, 3994-4000 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3994-4000
-
-
Rahmathullah, S.M.1
-
22
-
-
0036845742
-
Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl) furan across Caco-2 cell monolayers via its methylamidoidme prodrug
-
Zhou, L. et al. Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug. Pharm. Res. 19, 1689-1695 (2002).
-
(2002)
Pharm. Res.
, vol.19
, pp. 1689-1695
-
-
Zhou, L.1
-
23
-
-
3242663162
-
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue
-
Sturk, L.M., Brock, J.L., Bagnell, C.R., Hall, J.E. & Tidwell, R.R. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop. 91, 131-143 (2004).
-
(2004)
Acta Trop.
, vol.91
, pp. 131-143
-
-
Sturk, L.M.1
Brock, J.L.2
Bagnell, C.R.3
Hall, J.E.4
Tidwell, R.R.5
-
24
-
-
17544387144
-
Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries
-
Berman, J.D. et al. Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries. Bull. World Health Organ. 76, 25-32 (1998).
-
(1998)
Bull. World Health Organ.
, vol.76
, pp. 25-32
-
-
Berman, J.D.1
-
25
-
-
17844382393
-
Liposomal amphotericin B: Clinical experience and perspectives
-
Gibbs, W.J., Drew, R.H. & Perfect, J.R. Liposomal amphotericin B: clinical experience and perspectives. Expert Rev. Anti Infect. Ther. 3, 167-181 (2005).
-
(2005)
Expert Rev. Anti Infect. Ther.
, vol.3
, pp. 167-181
-
-
Gibbs, W.J.1
Drew, R.H.2
Perfect, J.R.3
-
26
-
-
0025361947
-
Dihydrofolate reductase as a therapeutic target
-
Schweitzer, B.I., Dicker, A.P. & Bertino, J.R. Dihydrofolate reductase as a therapeutic target. FASEB J. 4, 2441-2452 (1990).
-
(1990)
FASEB J.
, vol.4
, pp. 2441-2452
-
-
Schweitzer, B.I.1
Dicker, A.P.2
Bertino, J.R.3
-
27
-
-
0025409320
-
Thymidylate synthase-dihydrofolate reductase in protozoa
-
Ivanetich, K.M. & Santi, D.V. Thymidylate synthase-dihydrofolate reductase in protozoa. Exp. Parasitol. 70, 367-371 (1990).
-
(1990)
Exp. Parasitol.
, vol.70
, pp. 367-371
-
-
Ivanetich, K.M.1
Santi, D.V.2
-
28
-
-
0028403267
-
Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase
-
Knighton, D.R. et al. Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase. Nat. Struct. Biol. 1, 186-194 (1994).
-
(1994)
Nat. Struct. Biol.
, vol.1
, pp. 186-194
-
-
Knighton, D.R.1
-
29
-
-
0033577778
-
The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase
-
Zuccotto, F., Brun, R., Gonzalez Pacanowska, D., Ruiz Perez, L.M. & Gilbert, I.H. The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg. Med. Chem. Lett. 9, 1463-1468 (1999).
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 1463-1468
-
-
Zuccotto, F.1
Brun, R.2
Gonzalez Pacanowska, D.3
Ruiz Perez, L.M.4
Gilbert, I.H.5
-
30
-
-
0035329232
-
Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
-
Zuccotto, F. et al. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase. Eur. J. Med. Chem. 36, 395-405 (2001).
-
(2001)
Eur. J. Med. Chem.
, vol.36
, pp. 395-405
-
-
Zuccotto, F.1
-
31
-
-
0035938353
-
Novel inhibitors of leishmanial dihydrofolate reductase
-
Chowdhury, S.F. et al. Novel inhibitors of leishmanial dihydrofolate reductase. Bioorg. Med. Chem. Lett. 11, 977-980 (2001).
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 977-980
-
-
Chowdhury, S.F.1
-
32
-
-
0037130297
-
Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes
-
Gilbert, I.H. Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes. Biochim. Biophys. Acta 1587, 249-257 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1587
, pp. 249-257
-
-
Gilbert, I.H.1
-
33
-
-
0030946111
-
The roles of pteridine reductase 1 and dihydrofolate reductase- thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
-
Nare, B., Hardy, L.W. & Beverley, S.M. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J. Biol. Chem. 272, 13883-13891 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13883-13891
-
-
Nare, B.1
Hardy, L.W.2
Beverley, S.M.3
-
34
-
-
0023706778
-
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines
-
Sirawaraporn, W. et al. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines. Mol. Biochem. Parasitol. 31, 79-85 (1988).
-
(1988)
Mol. Biochem. Parasitol.
, vol.31
, pp. 79-85
-
-
Sirawaraporn, W.1
-
35
-
-
0032749527
-
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase
-
Chowdhury, S.F. et al. Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J. Med. Chem. 42, 4300-4312 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4300-4312
-
-
Chowdhury, S.F.1
-
36
-
-
10744224199
-
2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase
-
Pez, D. et al. 2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Bioorg. Med. Chem. 11, 4693-4711 (2003).
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 4693-4711
-
-
Pez, D.1
-
38
-
-
1642493673
-
Induced fit, drug design, and dUTPase
-
Stout, C.D. Induced fit, drug design, and dUTPase. Structure 12, 2-3 (2004).
-
(2004)
Structure
, vol.12
, pp. 2-3
-
-
Stout, C.D.1
-
39
-
-
13844296398
-
dUTPase as a platform for antimalarial drug design: Structural basis for the selectivity of a class of nucleoside inhibitors
-
Whittingham, J.L. et al. dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. Structure 13, 329-338 (2005).
-
(2005)
Structure
, vol.13
, pp. 329-338
-
-
Whittingham, J.L.1
-
40
-
-
0035933201
-
Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness
-
Hofer, A., Steverding, D., Chabes, A., Brun, R. & Thelander, L. Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Proc. Natl. Acad. Sci. USA 98, 6412-6416 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6412-6416
-
-
Hofer, A.1
Steverding, D.2
Chabes, A.3
Brun, R.4
Thelander, L.5
-
41
-
-
0036178381
-
Review: Cysteine proteases of parasitic organisms
-
Sajid, M. & McKerrow, J.H. Review: cysteine proteases of parasitic organisms. Mol. Biochem. Parasitol. 120, 1-21 (2002).
-
(2002)
Mol. Biochem. Parasitol.
, vol.120
, pp. 1-21
-
-
Sajid, M.1
McKerrow, J.H.2
-
42
-
-
0031691453
-
Antimalarial synergy of cysteine and aspartic protease inhibitors
-
Semenov, A., Olson, J.E. & Rosenthal, P.J. Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob. Agents Chemother. 42, 2254-2258 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 2254-2258
-
-
Semenov, A.1
Olson, J.E.2
Rosenthal, P.J.3
-
43
-
-
0035997361
-
Biological roles of proteases in parasitic protozoa
-
Klemba, M. & Goldberg, D.E. Biological roles of proteases in parasitic protozoa. Annu. Rev. Biochem. 71, 275-305 (2002).
-
(2002)
Annu. Rev. Biochem.
, vol.71
, pp. 275-305
-
-
Klemba, M.1
Goldberg, D.E.2
-
44
-
-
85029171281
-
Thiosemicarbazones and other compounds as antiparasitic compounds, their preparation, and methods of their use
-
WO patent application 2005/087211
-
Chibale, K., Greenbaum, D.C. & McKerrow, J.H. Thiosemicarbazones and other compounds as antiparasitic compounds, their preparation, and methods of their use. WO patent application 2005/087211 (2005).
-
(2005)
-
-
Chibale, K.1
Greenbaum, D.C.2
McKerrow, J.H.3
-
45
-
-
0037142343
-
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
-
Du, X. et al. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J. Med. Chem. 45, 2695-2707 (2002).
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2695-2707
-
-
Du, X.1
-
46
-
-
13044256387
-
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
-
Selzer, P.M. et al. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc. Natl. Acad. Sci. USA 96, 11015-11022 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11015-11022
-
-
Selzer, P.M.1
-
47
-
-
77952147853
-
Schistosomiasis mansoni: Novel chemotherapy using a cysteine protease inhibitor
-
(in the press)
-
Abdulla, M.-H., Lim, K.C., Sajid, M., McKerrow, J.H. & Caffrey, C.R. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. (in the press).
-
PLoS Med.
-
-
Abdulla, M.-H.1
Lim, K.C.2
Sajid, M.3
McKerrow, J.H.4
Caffrey, C.R.5
-
48
-
-
0028866134
-
The mechanisms of Trypanosoma cruzi invasion of mammalian cells
-
Burleigh, B.A. & Andrews, N.W. The mechanisms of Trypanosoma cruzi invasion of mammalian cells. Annu. Rev. Microbiol. 49, 175-200 (1995).
-
(1995)
Annu. Rev. Microbiol.
, vol.49
, pp. 175-200
-
-
Burleigh, B.A.1
Andrews, N.W.2
-
49
-
-
0037025351
-
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes
-
Salter, J.P. et al. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J. Biol. Chem. 277, 24618-24624 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24618-24624
-
-
Salter, J.P.1
-
50
-
-
0033527572
-
Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
-
Eggleson, K.K., Duffin, K.L. & Goldberg, D.E. Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum. J. Biol. Chem. 274, 32411-32417 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32411-32417
-
-
Eggleson, K.K.1
Duffin, K.L.2
Goldberg, D.E.3
-
51
-
-
33746748754
-
Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum
-
Madrid, P.B., Liou, A.P., DeRisi, J.L. & Guy, R.K. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. J. Med. Chem. 49, 4535-4543 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4535-4543
-
-
Madrid, P.B.1
Liou, A.P.2
DeRisi, J.L.3
Guy, R.K.4
-
52
-
-
85029164584
-
Chloroquine analogs, their preparation, and methods of preventing and treating plasmodial disease
-
WO patent application 96/40138
-
Krogstad, D.J. & De, D. Chloroquine analogs, their preparation, and methods of preventing and treating plasmodial disease. WO patent application 96/40138 (1996).
-
(1996)
-
-
Krogstad, D.J.1
De, D.2
-
53
-
-
0032481004
-
Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines
-
De, D., Krogstad, F.M., Byers, L.D. & Krogstad, D.J. Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines. J. Med. Chem. 41, 4918-4926 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4918-4926
-
-
De, D.1
Krogstad, F.M.2
Byers, L.D.3
Krogstad, D.J.4
-
54
-
-
16544371153
-
Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques
-
Ramanathan-Girish, S. et al. Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques. Int. J. Toxicol. 23, 179-189 (2004).
-
(2004)
Int. J. Toxicol.
, vol.23
, pp. 179-189
-
-
Ramanathan-Girish, S.1
-
55
-
-
85029175324
-
Preparation of anilino-quninolines as anti-malarial compounds
-
WO patent application 2002/072554
-
Park, B.K., O'Neill, P.M., Ward, S.A. & Stocks, P.A. Preparation of anilino-quninolines as anti-malarial compounds. WO patent application 2002/072554 (2002).
-
(2002)
-
-
Park, B.K.1
O'Neill, P.M.2
Ward, S.A.3
Stocks, P.A.4
-
56
-
-
85029163482
-
Ring-substituted 8-aminoquinoline analogs as antimalarial agents and process for their preparation
-
WO patent application 2004/085402
-
Jain, R. et al. Ring-substituted 8-aminoquinoline analogs as antimalarial agents and process for their preparation. WO patent application 2004/085402 (2004).
-
(2004)
-
-
Jain, R.1
-
57
-
-
85029158062
-
Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quinolinyl)-1, 4-pentanediamine as gametocytocidal agent
-
US patent application 2003199697
-
Pratap, R. et al. Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8- quinolinyl)-1,4-pentanediamine as gametocytocidal agent. US patent application 2003199697 (2003).
-
(2003)
-
-
Pratap, R.1
-
58
-
-
85029179194
-
Preparation of quinolizidinylalkylaminoquinolines as antimalarials
-
WO patent application 2005/037833
-
Sparatore, A. et al. Preparation of quinolizidinylalkylaminoquinolines as antimalarials. WO patent application 2005/037833 (2005).
-
(2005)
-
-
Sparatore, A.1
-
59
-
-
85029147797
-
Preparation of compounds which contain a 1,2,4-trioxane moiety linked to a quinoline moiety for pharmaceutical use as antimalarial agents
-
WO patent application 2001/077105
-
Meunier, B., Robert, A., Dechy-Cabaret, O. & Benoit-Vical, F. Preparation of compounds which contain a 1,2,4-trioxane moiety linked to a quinoline moiety for pharmaceutical use as antimalarial agents. WO patent application 2001/077105 (2001).
-
(2001)
-
-
Meunier, B.1
Robert, A.2
Dechy-Cabaret, O.3
Benoit-Vical, F.4
-
60
-
-
33745468499
-
Medicines for Malaria Venture: Sustaining antimalarial drug development
-
Bathurst, I. & Hentschel, C. Medicines for Malaria Venture: sustaining antimalarial drug development. Trends Parasitol. 22, 301-307 (2006).
-
(2006)
Trends Parasitol.
, vol.22
, pp. 301-307
-
-
Bathurst, I.1
Hentschel, C.2
-
61
-
-
2942666622
-
Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity
-
Haynes, R.K. et al. Highly antimalaria-active artemisinin derivatives: biological activity does not correlate with chemical reactivity. Angew. Chem. Int. Edn. Engl. 43, 1381-1385 (2004).
-
(2004)
Angew. Chem. Int. Edn. Engl.
, vol.43
, pp. 1381-1385
-
-
Haynes, R.K.1
-
62
-
-
0001123285
-
Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: Mechanism(s) of action
-
Cumming, J.N., Ploypradith, P. & Posner, G.H. Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action. Adv. Pharmacol. 37, 253-297 (1997).
-
(1997)
Adv. Pharmacol.
, vol.37
, pp. 253-297
-
-
Cumming, J.N.1
Ploypradith, P.2
Posner, G.H.3
-
63
-
-
0036001107
-
How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view
-
Wu, Y. How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view. Acc. Chem. Res. 35, 255-259 (2002).
-
(2002)
Acc. Chem. Res.
, vol.35
, pp. 255-259
-
-
Wu, Y.1
-
64
-
-
7944222115
-
Artemisinins: Mechanisms of action and potential for resistance
-
Krishna, S., Uhlemann, A.-C. & Haynes, R.K. Artemisinins: mechanisms of action and potential for resistance. Drug Resist. Updat. 7, 233-244 (2004).
-
(2004)
Drug Resist. Updat.
, vol.7
, pp. 233-244
-
-
Krishna, S.1
Uhlemann, A.-C.2
Haynes, R.K.3
-
65
-
-
0042860063
-
Artemisinins target the SERCA of Plasmodium falciparum
-
Eckstein-Ludwig, U. et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424, 957-961 (2003).
-
(2003)
Nature
, vol.424
, pp. 957-961
-
-
Eckstein-Ludwig, U.1
-
66
-
-
27744592680
-
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: Implications for the molecular mechanism of action of the artemisinins
-
O'Neill, P.M. et al. Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. ChemBioChem 6, 2048-2054 (2005).
-
(2005)
ChemBioChem
, vol.6
, pp. 2048-2054
-
-
O'Neill, P.M.1
-
67
-
-
2542640961
-
A medicinal chemistry perspective on artemisinin and related endoperoxides
-
O'Neill, P.M. & Posner, G.H. A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 47, 2945-2964 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2945-2964
-
-
O'Neill, P.M.1
Posner, G.H.2
-
68
-
-
21044434332
-
Convenient access both to highly antimalaria-active 10- arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate
-
Haynes, R.K. et al. Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate. ChemBioChem 6, 659-667 (2005).
-
(2005)
ChemBioChem
, vol.6
, pp. 659-667
-
-
Haynes, R.K.1
-
69
-
-
85029176171
-
Preparation of artemisinin derivatives for treating malaria, neosporosis and coccidiosis
-
European patent application 974354
-
Haynes, R.K., Lam, W.-L., Chan, H.-W. & Tsang, H.-W. Preparation of artemisinin derivatives for treating malaria, neosporosis and coccidiosis. European patent application 974354 (2000).
-
(2000)
-
-
Haynes, R.K.1
Lam, W.-L.2
Chan, H.-W.3
Tsang, H.-W.4
-
70
-
-
85029178843
-
Preparation of dihydroartemisinin derivatives as antimalarial and antitumor agents
-
WO patent application 2003/048167
-
O'Neill, P.M., Higson, A.P., Taylor, S. & Irving, E. Preparation of dihydroartemisinin derivatives as antimalarial and antitumor agents. WO patent application 2003/048167 (2003).
-
(2003)
-
-
O'Neill, P.M.1
Higson, A.P.2
Taylor, S.3
Irving, E.4
-
71
-
-
0032962098
-
Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family
-
Posner, G.H. et al. Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family. J. Med. Chem. 42, 300-304 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 300-304
-
-
Posner, G.H.1
-
72
-
-
0033619978
-
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether
-
O'Neill, P.M. et al. Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether. J. Med. Chem. 42, 5487-5493 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5487-5493
-
-
O'Neill, P.M.1
-
73
-
-
85029155797
-
Preparation of novel artemisinin derivatives and their use for treating malaria
-
WO patent application 2003/035651
-
Begue, J.-P. et al. Preparation of novel artemisinin derivatives and their use for treating malaria. WO patent application 2003/035651 (2003).
-
(2003)
-
-
Begue, J.-P.1
-
74
-
-
0037186497
-
Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues
-
Hindley, S. et al. Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. J. Med. Chem. 45, 1052-1063 (2002).
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1052-1063
-
-
Hindley, S.1
-
75
-
-
85029149394
-
Preparation of orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high selectivity, stability and efficacy
-
WO patent application 2004/028476
-
Posner, G.H. et al. Preparation of orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high selectivity, stability and efficacy. WO patent application 2004/028476 (2004).
-
(2004)
-
-
Posner, G.H.1
-
76
-
-
85029178843
-
Preparation of dihydroartemisinin derivatives as antimalarial and anticancer agents
-
WO patent application 2003/048168
-
O'Neill, P.M., Higson, A.P., Taylor, S. & Irving, E. Preparation of dihydroartemisinin derivatives as antimalarial and anticancer agents. WO patent application 2003/048168 (2003).
-
(2003)
-
-
O'Neill, P.M.1
Higson, A.P.2
Taylor, S.3
Irving, E.4
-
77
-
-
85029160289
-
Preparation of anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities
-
WO patent application 2006/002105
-
Mahmoud, A.E. & Waseem, G. Preparation of anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities. WO patent application 2006/002105 (2006).
-
(2006)
-
-
Mahmoud, A.E.1
Waseem, G.2
-
78
-
-
85029179233
-
Preparation of artemisinin derivatives as antiparasitic agents
-
European patent application 974593
-
Haynes, R.K. & Lam, W.-L. Preparation of artemisinin derivatives as antiparasitic agents. European patent application 974593 (2000).
-
(2000)
-
-
Haynes, R.K.1
Lam, W.-L.2
-
79
-
-
85029165805
-
Preparation of artemisinin-based peroxide compounds as broad spectrum anti-infective agents
-
WO patent application 2003/095444
-
Avery, M.A. & Muraleedharan, K.M. Preparation of artemisinin-based peroxide compounds as broad spectrum anti-infective agents. WO patent application 2003/095444 (2003).
-
(2003)
-
-
Avery, M.A.1
Muraleedharan, K.M.2
-
80
-
-
33751092100
-
Synthesis and antiparasitic activity of artemisinin derivatives (endoperoxides)
-
WO patent application 2000/004024
-
Haynes, R.K., Chan, H.-W., Lam, W.-L., Tsang, H.-W. & Cheung, M.-K. Synthesis and antiparasitic activity of artemisinin derivatives (endoperoxides). WO patent application 2000/004024 (2000).
-
(2000)
-
-
Haynes, R.K.1
Chan, H.-W.2
Lam, W.-L.3
Tsang, H.-W.4
Cheung, M.-K.5
-
81
-
-
33751071443
-
Preparation of antiparasitic artemisinin derivatives (sesquiterpene endoperoxides)
-
WO patent application 2003/076446
-
Haynes, R.K. Preparation of antiparasitic artemisinin derivatives (sesquiterpene endoperoxides). WO patent application 2003/076446 (2003).
-
(2003)
-
-
Haynes, R.K.1
-
82
-
-
33745975677
-
Artemisone - A highly active antimalarial drug of the artemisinin class
-
Haynes, R.K. et al. Artemisone - a highly active antimalarial drug of the artemisinin class. Angew. Chem. Int. Ed. 45, 2082-2088 (2006).
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 2082-2088
-
-
Haynes, R.K.1
-
83
-
-
85029168030
-
-
Medicines for Malaria Venture
-
Medicines for Malaria Venture. Curing malaria together: annual report 2005. Medicines for Malaria Venture 〈http://www.mmv.org/IMG/pdf/ full_report.pdf〉 (2005).
-
(2005)
Curing Malaria Together: Annual Report 2005
-
-
-
84
-
-
0032510451
-
Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation
-
Posner, G.H. et al. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. J. Med. Chem. 41, 940-951 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 940-951
-
-
Posner, G.H.1
-
85
-
-
33646459918
-
Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxa spiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice
-
Singh, C., Malik, H. & Puri, S.K. Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxa spiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice. J. Med. Chem. 49, 2794-2803 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2794-2803
-
-
Singh, C.1
Malik, H.2
Puri, S.K.3
-
86
-
-
33745081807
-
Blood schizontocidal activity of selected 1,2,4-trioxanes (fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo
-
Tripathi, R., Jefford, C.W. & Dutta, G.P. Blood schizontocidal activity of selected 1,2,4-trioxanes (fenozans) against the multidrug-resistant strain of Plasmodium yoelii nigeriensis (MDR) in vivo. Parasitology 133, 1-9 (2006).
-
(2006)
Parasitology
, vol.133
, pp. 1-9
-
-
Tripathi, R.1
Jefford, C.W.2
Dutta, G.P.3
-
87
-
-
33751120002
-
Preparation of spiro/dispiro-1,2,4-trioxolanes as antimalarial agents
-
US patent 6,486,199
-
Vennerstrom, J.L., Dong, Y., Chollet, J. & Matile, H. Preparation of spiro/dispiro-1,2,4-trioxolanes as antimalarial agents. US patent 6,486,199 (2002).
-
(2002)
-
-
Vennerstrom, J.L.1
Dong, Y.2
Chollet, J.3
Matile, H.4
-
88
-
-
85029175125
-
Preparation of spiro- and dispiro-1,2,4-trioxolanes as antimalarial agents, schistosomicides, and anticancer agents
-
US patent application 2004039008
-
Vennerstrom, J.L. et al. Preparation of spiro- and dispiro-1,2,4- trioxolanes as antimalarial agents, schistosomicides, and anticancer agents. US patent application 2004039008 (2004).
-
(2004)
-
-
Vennerstrom, J.L.1
-
89
-
-
4344630762
-
Identification of an antimalarial synthetic trioxolane drug development candidate
-
Vennerstrom, J.L. et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430, 900-904 (2004).
-
(2004)
Nature
, vol.430
, pp. 900-904
-
-
Vennerstrom, J.L.1
-
90
-
-
22744432838
-
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes
-
Dong, Y. et al. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J. Med. Chem. 48, 4953-4961 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4953-4961
-
-
Dong, Y.1
-
91
-
-
18744417592
-
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: Alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes
-
Vennerstrom, J.L. et al. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes. J. Med. Chem. 43, 2753-2758 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2753-2758
-
-
Vennerstrom, J.L.1
-
92
-
-
0035811454
-
Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes
-
Kim, H.S. et al. Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes. J. Med. Chem. 44, 2357-2361 (2001).
-
(2001)
J. Med. Chem.
, vol.44
, pp. 2357-2361
-
-
Kim, H.S.1
-
93
-
-
0032482445
-
Antimalarial cyclic peroxy ketals
-
Posner, G.H. et al. Antimalarial cyclic peroxy ketals. J. Med. Chem. 41, 2164-2167 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2164-2167
-
-
Posner, G.H.1
-
94
-
-
0028170770
-
Ro 42-1611 (arteflene), a new effective antimalarial: Chemical structure and biological activity
-
Hofheinz, W. et al. Ro 42-1611 (arteflene), a new effective antimalarial: chemical structure and biological activity. Trop. Med. Parasitol. 45, 261-265 (1994).
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 261-265
-
-
Hofheinz, W.1
-
95
-
-
0038440391
-
A short synthesis and biological evaluation of potent and non-toxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides
-
Bachi, M.D. et al. A short synthesis and biological evaluation of potent and non-toxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides. J. Med. Chem. 46, 2516-2533 (2003).
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2516-2533
-
-
Bachi, M.D.1
-
96
-
-
4544263432
-
Design and synthesis of endoperoxide antimalarial prodrug models
-
O'Neill, P.M. et al. Design and synthesis of endoperoxide antimalarial prodrug models. Angew. Chem. Int. Ed. 43, 4193-4197 (2004).
-
(2004)
Angew. Chem. Int. Ed.
, vol.43
, pp. 4193-4197
-
-
O'Neill, P.M.1
-
97
-
-
0032510451
-
Orally active antimalarial 3-substituted trioxanes: New synthetic methodology and biological evaluation
-
Posner, G.H. et al. Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation. J. Med. Chem. 41, 940-951 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 940-951
-
-
Posner, G.H.1
-
98
-
-
85029188902
-
Synthesis and activity of water-soluble trioxanes as potent and safe antimalarial agents
-
WO patent application 2000/059501
-
Posner, G.H., Parker, M.H., Krasavin, M. & Shapiro, T.A. Synthesis and activity of water-soluble trioxanes as potent and safe antimalarial agents. WO patent application 2000/059501 (2000).
-
(2000)
-
-
Posner, G.H.1
Parker, M.H.2
Krasavin, M.3
Shapiro, T.A.4
-
99
-
-
33845363105
-
Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof
-
WO patent application 2003082852
-
Singh, C., Tiwari, P. & Puri, S.K. Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof. WO patent application 2003082852 (2003).
-
(2003)
-
-
Singh, C.1
Tiwari, P.2
Puri, S.K.3
-
100
-
-
85029169464
-
1,2,4-Trioxanes and 1,2,4-trioxepanes useful as antimalarial and anticancer agents, and their pharmaceutical compositions, use, and preparation via the thiol-olefin co-oxygenation (TOCO) reaction
-
US patent application 2005256184
-
O'Neill, P.M., Amewu, R., Mukhtar, A. & Ward, S.A. 1,2,4-Trioxanes and 1,2,4-trioxepanes useful as antimalarial and anticancer agents, and their pharmaceutical compositions, use, and preparation via the thiol-olefin co-oxygenation (TOCO) reaction. US patent application 2005256184 (2005).
-
(2005)
-
-
O'Neill, P.M.1
Amewu, R.2
Mukhtar, A.3
Ward, S.A.4
-
101
-
-
17744377209
-
Total syntheses of yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities
-
Szpilman, A.M., Korshin, E.E., Rozenberg, H. & Bachi, M.D. Total syntheses of yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities. J. Org. Chem. 70, 3618-3632 (2005).
-
(2005)
J. Org. Chem.
, vol.70
, pp. 3618-3632
-
-
Szpilman, A.M.1
Korshin, E.E.2
Rozenberg, H.3
Bachi, M.D.4
-
102
-
-
67849104407
-
Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis
-
US patent application 2005256185
-
Vennerstrom, J.L. et al. Spiro and dispiro 1,2,4-trioxolane antimalarials, and their preparation, pharmaceutical compositions, and use in the treatment of malaria, cancer, and schistosomiasis. US patent application 2005256185 (2005).
-
(2005)
-
-
Vennerstrom, J.L.1
-
103
-
-
33748767111
-
Therapeutic intervention based on protein prenylation and associated modifications
-
Gelb, M.H. et al. Therapeutic intervention based on protein prenylation and associated modifications. Nat. Chem. Biol. 2, 518-528 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 518-528
-
-
Gelb, M.H.1
-
104
-
-
0026577976
-
Protein prenyltransferases
-
Yokoyama, K., Goodwin, G.W., Ghomashchi, F., Glomset, J. & Gelb, M.H. Protein prenyltransferases. Biochem. Soc. Trans. 20, 489-494 (1992).
-
(1992)
Biochem. Soc. Trans.
, vol.20
, pp. 489-494
-
-
Yokoyama, K.1
Goodwin, G.W.2
Ghomashchi, F.3
Glomset, J.4
Gelb, M.H.5
-
105
-
-
0030865773
-
Ras farnesyltransferase: A new therapeutic target
-
Leonard, D.M. Ras farnesyltransferase: a new therapeutic target. J. Med. Chem. 40, 2971-2990 (1997).
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2971-2990
-
-
Leonard, D.M.1
-
106
-
-
33244474617
-
Fighting parasitic disease by blocking protein farnesylation
-
Eastman, R.T., Buckner, F.S., Yokoyama, K., Gelb, M.H. & Van Voorhis, W.C. Fighting parasitic disease by blocking protein farnesylation. J. Lipid Res. 47, 233-240 (2006).
-
(2006)
J. Lipid Res.
, vol.47
, pp. 233-240
-
-
Eastman, R.T.1
Buckner, F.S.2
Yokoyama, K.3
Gelb, M.H.4
Van Voorhis, W.C.5
-
107
-
-
0345073644
-
Protein farnesyl and N-myristoyl transferases: Piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
-
Gelb, M.H. et al. Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol. Biochem. Parasitol. 126, 155-163 (2003).
-
(2003)
Mol. Biochem. Parasitol.
, vol.126
, pp. 155-163
-
-
Gelb, M.H.1
-
108
-
-
20144373679
-
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
-
Nallan, L. et al. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J. Med. Chem. 48, 3704-3713 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3704-3713
-
-
Nallan, L.1
-
109
-
-
33748858487
-
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites
-
Glenn, M.P. et al. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. J. Med. Chem. 49, 5710-5727 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 5710-5727
-
-
Glenn, M.P.1
-
110
-
-
0017366999
-
Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: The glycosome
-
Opperdoes, F.R. & Borst, P. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett. 80, 360-364 (1977).
-
(1977)
FEBS Lett.
, vol.80
, pp. 360-364
-
-
Opperdoes, F.R.1
Borst, P.2
-
111
-
-
0030560864
-
Metabolic compartmentation in African trypanosomes
-
Clayton, C.E. & Michels, P. Metabolic compartmentation in African trypanosomes. Parasitol. Today 12, 465-471 (1996).
-
(1996)
Parasitol. Today
, vol.12
, pp. 465-471
-
-
Clayton, C.E.1
Michels, P.2
-
112
-
-
0035339822
-
Enzymes of carbohydrate metabolism as potential drug targets
-
Opperdoes, F.R. & Michels, P.A. Enzymes of carbohydrate metabolism as potential drug targets. Int. J. Parasitol. 31, 482-490 (2001).
-
(2001)
Int. J. Parasitol.
, vol.31
, pp. 482-490
-
-
Opperdoes, F.R.1
Michels, P.A.2
-
113
-
-
0035062226
-
Glycolysis as a target for the design of new anti-trypanosome drugs
-
Verlinde, C.L.M.J. et al. Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist. Updat. 4, 50-65 (2001).
-
(2001)
Drug Resist. Updat.
, vol.4
, pp. 50-65
-
-
Verlinde, C.L.M.J.1
-
114
-
-
1642335814
-
History of the development of azole derivatives
-
Maertens, J.A. History of the development of azole derivatives. Clin. Microbiol. Infect. 10 (suppl.), 1-10 (2004).
-
(2004)
Clin. Microbiol. Infect.
, vol.10
, Issue.SUPPL.
, pp. 1-10
-
-
Maertens, J.A.1
-
115
-
-
16244416503
-
Second-generation azole antifungal agents
-
Kale, P. & Johnson, L.B. Second-generation azole antifungal agents. Drugs Today (Barc) 41, 91-105 (2005).
-
(2005)
Drugs Today (Barc)
, vol.41
, pp. 91-105
-
-
Kale, P.1
Johnson, L.B.2
-
116
-
-
17944384088
-
Treatment of chronic Chagas' disease with itraconazole and allopurinol
-
Apt, W. et al. Treatment of chronic Chagas' disease with itraconazole and allopurinol. Am. J. Trop. Med. Hyg. 59, 133-138 (1998).
-
(1998)
Am. J. Trop. Med. Hyg.
, vol.59
, pp. 133-138
-
-
Apt, W.1
-
117
-
-
0024235435
-
Failure of ketoconazole to cure chronic murine Chagas' disease
-
McCabe, R. Failure of ketoconazole to cure chronic murine Chagas' disease. J. Infect. Dis. 158, 1408-1409 (1988).
-
(1988)
J. Infect. Dis.
, vol.158
, pp. 1408-1409
-
-
McCabe, R.1
-
118
-
-
0027484860
-
An experimental and clinical assay with ketoconazole in the treatment of Chagas disease
-
Brener, Z. et al. An experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Mem. Inst. Oswaldo Cruz 88, 149-153 (1993).
-
(1993)
Mem. Inst. Oswaldo Cruz
, vol.88
, pp. 149-153
-
-
Brener, Z.1
-
119
-
-
7244219956
-
Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts
-
Guedes, P.M. et al. Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts. Antimicrob. Agents Chemother. 48, 4286-4292 (2004).
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4286-4292
-
-
Guedes, P.M.1
-
120
-
-
0031761201
-
Induction of resistance to azole drugs in Trypanosoma cruzi
-
Buckner, F.S., Wilson, A.J., White, T.C. & Van Voorhis, W.C. Induction of resistance to azole drugs in Trypanosoma cruzi. Antimicrob. Agents Chemother. 42, 3245-3250 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 3245-3250
-
-
Buckner, F.S.1
Wilson, A.J.2
White, T.C.3
Van Voorhis, W.C.4
-
121
-
-
25844444087
-
Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors
-
Hankins, E.G., Gillespie, J.R., Aikenhead, K. & Buckner, F.S. Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol. Biochem. Parasitol. 144, 68-75 (2005).
-
(2005)
Mol. Biochem. Parasitol.
, vol.144
, pp. 68-75
-
-
Hankins, E.G.1
Gillespie, J.R.2
Aikenhead, K.3
Buckner, F.S.4
-
122
-
-
0031807492
-
Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
-
Urbina, J.A. et al. Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob. Agents Chemother. 42, 1771-1777 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 1771-1777
-
-
Urbina, J.A.1
-
123
-
-
0033987127
-
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts
-
Molina, J. et al. Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Antimicrob. Agents Chemother. 44, 150-155 (2000).
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 150-155
-
-
Molina, J.1
-
124
-
-
29144480979
-
Protein kinases as drug targets in trypanosomes and Leishmania
-
Naula, C., Parsons, M. & Mottram, J.C. Protein kinases as drug targets in trypanosomes and Leishmania. Biochim. Biophys. Acta 1754, 151-159 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1754
, pp. 151-159
-
-
Naula, C.1
Parsons, M.2
Mottram, J.C.3
-
125
-
-
1542315532
-
New ways with old bones. Osteoporosis researchers look for drugs to replace hormone replacement therapy
-
Bonn, D. New ways with old bones. Osteoporosis researchers look for drugs to replace hormone replacement therapy. Lancet 363, 786-787 (2004).
-
(2004)
Lancet
, vol.363
, pp. 786-787
-
-
Bonn, D.1
-
126
-
-
0037078250
-
Kwanzoquinones A-G and other constituents of Hemerocallis fulva 'Kwanzo' roots and their acivity against the human trematode parasite, Schistosoma mansoni
-
Cichewicz, R.H., Lim, K.C., McKerrow, J.H. & Nair, M.G. Kwanzoquinones A-G and other constituents of Hemerocallis fulva 'Kwanzo' roots and their acivity against the human trematode parasite, Schistosoma mansoni. Tetrahedron 58, 8597-8606 (2002).
-
(2002)
Tetrahedron
, vol.58
, pp. 8597-8606
-
-
Cichewicz, R.H.1
Lim, K.C.2
McKerrow, J.H.3
Nair, M.G.4
-
127
-
-
0035813213
-
Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel
-
Kohn, A.B., Anderson, P.A., Roberts-Misterly, J.M. & Greenberg, R.M. Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J. Biol. Chem. 276, 36873-36876 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36873-36876
-
-
Kohn, A.B.1
Anderson, P.A.2
Roberts-Misterly, J.M.3
Greenberg, R.M.4
-
128
-
-
0030607410
-
Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo
-
Wasilewski, M.M., Lim, K.C., Phillips, J. & McKerrow, J.H. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol. Biochem. Parasitol. 81, 179-189 (1996).
-
(1996)
Mol. Biochem. Parasitol.
, vol.81
, pp. 179-189
-
-
Wasilewski, M.M.1
Lim, K.C.2
Phillips, J.3
McKerrow, J.H.4
-
129
-
-
33745199861
-
Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei
-
Mackey, Z.B. et al. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem. Biol. Drug Des. 67, 355-363 (2006).
-
(2006)
Chem. Biol. Drug Des.
, vol.67
, pp. 355-363
-
-
Mackey, Z.B.1
-
130
-
-
31944436271
-
Novel compounds active against Leishmania major
-
St. George, S., Bishop, J.V., Titus, R.G. & Selitrennikoff, C.P. Novel compounds active against Leishmania major. Antimicrob. Agents Chemother. 50, 474-479 (2006).
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 474-479
-
-
St George, S.1
Bishop, J.V.2
Titus, R.G.3
Selitrennikoff, C.P.4
-
131
-
-
33746169858
-
Searching for new antimalarial therapeutics amongst known drugs
-
Weisman, J.L. et al. Searching for new antimalarial therapeutics amongst known drugs. Chem. Biol. Drug Des. 67, 409-416 (2006).
-
(2006)
Chem. Biol. Drug Des.
, vol.67
, pp. 409-416
-
-
Weisman, J.L.1
-
132
-
-
33746381549
-
A clinical drug library screen identifies astemizole as an antimalarial agent
-
Chong, C.R., Chen, X., Shi, L., Liu, J.O. & Sullivan, D.J. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat. Chem. Biol. 2, 415-416 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 415-416
-
-
Chong, C.R.1
Chen, X.2
Shi, L.3
Liu, J.O.4
Sullivan, D.J.5
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