A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides

Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2003, Pages 2516-2533

  Bachi, Mario D ^a   Korshin, Edward E ^a   Hoos, Roland ^a   Szpilman, Alex M ^a   Ploypradith, Poonsakdi ^b   Xie, Suji ^c   Shapiro, Theresa A ^c   Posner, Gary H ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOXY DERIVATIVE; ANTIMALARIAL AGENT; ARTEETHER; ARTEFLENE; ARTELINIC ACID; ARTEMETHER; ARTEMISININ; BETA SULFINYL PEROXIDE; BETA SULFONYL ENDOPEROXIDE DERIVATIVE; BETA SULFONYL PEROXIDE; CHLOROQUINE; FREE RADICAL; HYDROXYL GROUP; PEROXIDE; SULFUR DERIVATIVE; THIOL DERIVATIVE; THIOL MONOTERPENE; TRIOXANE DERIVATIVE; UNCLASSIFIED DRUG; YINGZHAOSU A;

ACYLATION; ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; CLINICAL TRIAL; DEHYDRATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HYDROGENATION; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MOUSE; NEUROTOXICITY; NONHUMAN; OXYGENATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; SIDE EFFECT;

ANIMALS; ANTIMALARIALS; BICYCLO COMPOUNDS, HETEROCYCLIC; MALARIA; MALE; MICE; MICE, INBRED ICR; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 0038440391     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020584a     Document Type: Article

References (104)

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