Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4321-4335

  Avery, Mitchell A ^a,b   Alvim Gaston, Maria ^a,c   Vroman, Jeffrey A ^a,d   Wu, Baogen ^a,e   Ager, Arba ^f   Peters, Wallace ^g   Robinson, Brian L ^g   Charman, William ^h  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d EASTMAN KODAK COMPANY   (United States)

^e GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^g NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^h MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

16 PROPYL 10 DEOXOARTEMISININ; ANTIMALARIAL AGENT; AROMATIC COMPOUND; ARTEMISINIC ACID; ARTEMISININ; CARBONYL DERIVATIVE; CHLOROQUINE; HALOGEN; LACTONE DERIVATIVE; MEFLOQUINE; OCTAHYDRO 3,6ALPHA DIMETHYL 3,12 EPOXY 9BETA [3' (3 TRIFLUOROMETHYLPHENYL)PROPYL] 12H PYRANO[4,3 J] 1,2 BENZODIOXEPIN; OCTAHYDRO 3,6ALPHA DIMETHYL 3,12 EPOXY 9BETA [3' (3,4 DICHLOROPHENYL)PROPYL] 12H PYRANO[4,3 J] 1,2 BENZODIOXEPIN; PYRAN DERIVATIVE; QUININE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MALE; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; REACTION ANALYSIS; REDUCTION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; INJECTIONS, INTRAVENOUS; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037068498     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020142z     Document Type: Article

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