-
1
-
-
3142587028
-
Tumor microenvironmental physiology and its implications for radiation oncology
-
Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Sem Radiat Oncol. 2004; 14: 198-206.
-
(2004)
Sem Radiat Oncol
, vol.14
, pp. 198-206
-
-
Vaupel, P.1
-
2
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer. 2004; 4: 437-47.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
3
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer. 2002; 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
5
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; 3: 721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
6
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001; 107: 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
-
7
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol Cell. 2008; 30: 393-402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
8
-
-
0344667645
-
Endogenous markers of tumor hypoxia predictors of clinical radiation resistance?
-
Vordermark D, Brown JM. Endogenous markers of tumor hypoxia predictors of clinical radiation resistance? Strahlenther Onkol. 2003; 179: 801-11.
-
(2003)
Strahlenther Onkol
, vol.179
, pp. 801-811
-
-
Vordermark, D.1
Brown, J.M.2
-
9
-
-
33745049797
-
VHL and p53: Tumor suppressors team up to prevent cancer
-
Semenza GL. VHL and p53: Tumor suppressors team up to prevent cancer. Mol Cell. 2006; 22: 437-9.
-
(2006)
Mol Cell
, vol.22
, pp. 437-739
-
-
Semenza, G.L.1
-
11
-
-
0032780848
-
The OxyLite: A fibre-optic oxygen sensor
-
Griffiths JR, Robinson SP. The OxyLite: A fibre-optic oxygen sensor. Br J Radiol. 1999; 72: 627-30.
-
(1999)
Br J Radiol
, vol.72
, pp. 627-630
-
-
Griffiths, J.R.1
Robinson, S.P.2
-
12
-
-
0028785458
-
Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
-
Arteel GE, Thurman RG, Yates JM, Raleigh JA. Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br J Cancer. 1995; 72: 889-95.
-
(1995)
Br J Cancer
, vol.72
, pp. 889-895
-
-
Arteel, G.E.1
Thurman, R.G.2
Yates, J.M.3
Raleigh, J.A.4
-
13
-
-
38549166422
-
New approaches for imaging tumour responses to treatment
-
Brindle K. New approaches for imaging tumour responses to treatment. Nat Rev Cancer. 2008; 8: 94-107.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 94-107
-
-
Brindle, K.1
-
14
-
-
0032801526
-
Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors
-
Raleigh JA, Chou SC, Arteel GE, Horsman MR. Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiat Res. 1999; 151: 580-9.
-
(1999)
Radiat Res
, vol.151
, pp. 580-589
-
-
Raleigh, J.A.1
Chou, S.C.2
Arteel, G.E.3
Horsman, M.R.4
-
15
-
-
23844485492
-
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
-
Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P. Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res. 2005; 65: 7259-66.
-
(2005)
Cancer Res
, vol.65
, pp. 7259-7266
-
-
Sobhanifar, S.1
Aquino-Parsons, C.2
Stanbridge, E.J.3
Olive, P.4
-
16
-
-
21844455567
-
Hypoxia in head and neck cancer: How much, how important?
-
Janssen HL, Haustermans KM, Balm AJ, Begg AC. Hypoxia in head and neck cancer: How much, how important? Head Neck. 2005; 27: 622-38.
-
(2005)
Head Neck
, vol.27
, pp. 622-638
-
-
Janssen, H.L.1
Haustermans, K.M.2
Balm, A.J.3
Begg, A.C.4
-
17
-
-
11244287240
-
Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry
-
Dubois L, Landuyt W, Haustermans K et al. Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry. Br J Cancer. 2004; 91: 1947-54.
-
(2004)
Br J Cancer
, vol.91
, pp. 1947-1954
-
-
Dubois, L.1
Landuyt, W.2
Haustermans, K.3
-
18
-
-
54249165055
-
Noninvasive molecular imaging of hypoxia in human xenografts: Comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers
-
He F, Deng X, Wen B et al. Noninvasive molecular imaging of hypoxia in human xenografts: Comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. Cancer Res. 2008; 68: 8597-606.
-
(2008)
Cancer Res
, vol.68
, pp. 8597-8606
-
-
He, F.1
Deng, X.2
Wen, B.3
-
19
-
-
0036883983
-
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors
-
Janssen HL, Haustermans KM, Sprong D et al. HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. Int J Radiat Oncol Biol Phys. 2002; 54: 1537-49.
-
(2002)
Int J Radiat Oncol Biol Phys
, vol.54
, pp. 1537-1549
-
-
Janssen, H.L.1
Haustermans, K.M.2
Sprong, D.3
-
20
-
-
43049109160
-
Aerobic glycolysis in cancers: Implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia
-
Busk M, Horsman MR, Kristjansen PE, van der Kogel AJ, Bussink J, Overgaard J. Aerobic glycolysis in cancers: Implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia. Int J Cancer. 2008; 122: 2726-34.
-
(2008)
Int J Cancer
, vol.122
, pp. 2726-2734
-
-
Busk, M.1
Horsman, M.R.2
Kristjansen, P.E.3
van der Kogel, A.J.4
Bussink, J.5
Overgaard, J.6
-
21
-
-
0018760476
-
Evidence for acutely hypoxic cells in mouse tumors and a possible mechanism of reoxygenation
-
Brown JM. Evidence for acutely hypoxic cells in mouse tumors and a possible mechanism of reoxygenation. Br J Radiol. 1979; 52: 650-6.
-
(1979)
Br J Radiol
, vol.52
, pp. 650-656
-
-
Brown, J.M.1
-
24
-
-
44449099768
-
Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke
-
Takasawa M, Moustafa RR, Baron JC. Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke. Stroke. 2008; 39: 1629-37.
-
(2008)
Stroke
, vol.39
, pp. 1629-1637
-
-
Takasawa, M.1
Moustafa, R.R.2
Baron, J.C.3
-
26
-
-
0017256549
-
Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells
-
Mohindra JK, Rauth AM. Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells. Cancer Res. 1976; 36: 930-6.
-
(1976)
Cancer Res
, vol.36
, pp. 930-936
-
-
Mohindra, J.K.1
Rauth, A.M.2
-
27
-
-
0027481272
-
Nitroimidazole drugs - Action and resistance mechanisms. II. Mechanisms of resistance
-
Edwards DI. Nitroimidazole drugs - action and resistance mechanisms. II. Mechanisms of resistance. J Antimicrob Chemother. 1993; 31: 201-10.
-
(1993)
J Antimicrob Chemother
, vol.31
, pp. 201-210
-
-
Edwards, D.I.1
-
28
-
-
33845351323
-
Design of hypoxia-targeting drugs as new cancer chemotherapeutics
-
Nagasawa H, Uto Y, Kirk KL, Hori H. Design of hypoxia-targeting drugs as new cancer chemotherapeutics. Biol Pharm Bull. 2006; 29: 2335-42.
-
(2006)
Biol Pharm Bull
, vol.29
, pp. 2335-2342
-
-
Nagasawa, H.1
Uto, Y.2
Kirk, K.L.3
Hori, H.4
-
29
-
-
34347240794
-
Chemical radiosensitizers for use in radiotherapy
-
Wardman P. Chemical radiosensitizers for use in radiotherapy. Clin Oncol (R Coll Radiol). 2007; 19: 397-417.
-
(2007)
Clin Oncol (R Coll Radiol)
, vol.19
, pp. 397-417
-
-
Wardman, P.1
-
30
-
-
0027290844
-
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: With particular reference to in.vivo methods of evaluation
-
Bremner JC. Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: With particular reference to in.vivo methods of evaluation. Cancer Metastasis Rev. 1993; 12: 177-93.
-
(1993)
Cancer Metastasis Rev
, vol.12
, pp. 177-193
-
-
Bremner, J.C.1
-
31
-
-
0034285733
-
The role of hypoxia-activated prodrugs in cancer therapy
-
Denny WA. The role of hypoxia-activated prodrugs in cancer therapy. Lancet Oncol. 2000; 1: 25-9.
-
(2000)
Lancet Oncol
, vol.1
, pp. 25-29
-
-
Denny, W.A.1
-
32
-
-
4444317357
-
Angiogenesis inhibitor TX-1898: Syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers
-
Jin CZ, Nagasawa H, Shimamura M et al. Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers. Bioorg Med Chem. 2004; 12: 4917-27.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 4917-4927
-
-
Jin, C.Z.1
Nagasawa, H.2
Shimamura, M.3
-
33
-
-
0031656984
-
Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia
-
Hodgkiss RJ. Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia. Anticancer Drug Des. 1998; 13: 687-702.
-
(1998)
Anticancer Drug Des
, vol.13
, pp. 687-702
-
-
Hodgkiss, R.J.1
-
34
-
-
0000116995
-
Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxyamino) imidazoles
-
Bolton JL, McClelland RA. Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxyamino) imidazoles. J Am Chem Soc. 1989; 111: 8172-81.
-
(1989)
J Am Chem Soc
, vol.111
, pp. 8172-8181
-
-
Bolton, J.L.1
McClelland, R.A.2
-
35
-
-
33845368902
-
Effects of free radicals from hypoxic cell radiosensitizers, hypoxic cell cytotoxins, and bioreductive anticancer drugs on the biological environment, environmental oxidants
-
In: Nriagu O, Simmons MS, eds. New York: John Wiley and Sons
-
Hori H, Nagasawa H, Terada H. Effects of free radicals from hypoxic cell radiosensitizers, hypoxic cell cytotoxins, and bioreductive anticancer drugs on the biological environment, environmental oxidants. In: Nriagu O, Simmons MS, eds. Environmental Oxidants. New York: John Wiley and Sons, 1994: 425-44.
-
(1994)
Environmental Oxidants
, pp. 425-444
-
-
Hori, H.1
Nagasawa, H.2
Terada, H.3
-
36
-
-
0023892307
-
The metabolic activation of nitroheterocyclic therapeutic agents
-
Kedderis GL, Miwa GT. The metabolic activation of nitroheterocyclic therapeutic agents. Drug Metab Rev. 1988; 19: 33-62.
-
(1988)
Drug Metab Rev
, vol.19
, pp. 33-62
-
-
Kedderis, G.L.1
Miwa, G.T.2
-
37
-
-
0034284649
-
Role of NADPH: Cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia
-
Melo T, Ballinger JR, Rauth AM. Role of NADPH: Cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia. Biochem Pharmacol. 2000; 60: 625-34.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 625-634
-
-
Melo, T.1
Ballinger, J.R.2
Rauth, A.M.3
-
38
-
-
39949085225
-
Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity
-
Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008; 44: 1169-79.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 1169-1179
-
-
Wang, Y.1
Gray, J.P.2
Mishin, V.3
Heck, D.E.4
Laskin, D.L.5
Laskin, J.D.6
-
39
-
-
0035468967
-
Aerobic nitroreduction by flavoproteins: Enzyme structure, mechanisms and role in cancer chemotherapy
-
Skelly JV, Knox RJ, Jenkins TC. Aerobic nitroreduction by flavoproteins: enzyme structure, mechanisms and role in cancer chemotherapy. Mini Rev Med Chem. 2001; 1: 293-306.
-
(2001)
Mini Rev Med Chem
, vol.1
, pp. 293-306
-
-
Skelly, J.V.1
Knox, R.J.2
Jenkins, T.C.3
-
40
-
-
0842324834
-
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors
-
Janssen HL, Hoebers FJ, Sprong D et al. Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors. Radiother Oncol. 2004; 70: 91-7.
-
(2004)
Radiother Oncol
, vol.70
, pp. 91-97
-
-
Janssen, H.L.1
Hoebers, F.J.2
Sprong, D.3
-
41
-
-
0142250365
-
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: Pimonidazole and involucrin
-
Azuma Y, Chou SC, Lininger RA, Murphy BJ, Varia MA, Raleigh JA. Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin. Clin Cancer Res. 2003; 9: 4944-52.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4944-4952
-
-
Azuma, Y.1
Chou, S.C.2
Lininger, R.A.3
Murphy, B.J.4
Varia, M.A.5
Raleigh, J.A.6
-
42
-
-
0026521493
-
Retention of misonidazole in normal and malignant tissues: Interplay of hypoxia and reductases
-
Cobb LM, Nolan J, Hacker T. Retention of misonidazole in normal and malignant tissues: Interplay of hypoxia and reductases. Int J Radiat Oncol Biol Phys. 1992; 22: 655-9.
-
(1992)
Int J Radiat Oncol Biol Phys
, vol.22
, pp. 655-659
-
-
Cobb, L.M.1
Nolan, J.2
Hacker, T.3
-
43
-
-
0024978425
-
Correlation of kinetic parameters of nitroreductase enzymes with redox properties of nitroaromatic compounds
-
Orna MV, Mason RP. Correlation of kinetic parameters of nitroreductase enzymes with redox properties of nitroaromatic compounds. J Biol Chem. 1989; 264: 12 379-84.
-
(1989)
J Biol Chem
, vol.264
, pp. 12379-12384
-
-
Orna, M.V.1
Mason, R.P.2
-
44
-
-
0016977447
-
Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers
-
Adams GE, Flockhart IR, Smithen CE, Stratford IJ, Wardman P, Watts ME. Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers. Radiat Res. 1976; 67: 9-20.
-
(1976)
Radiat Res
, vol.67
, pp. 9-20
-
-
Adams, G.E.1
Flockhart, I.R.2
Smithen, C.E.3
Stratford, I.J.4
Wardman, P.5
Watts, M.E.6
-
45
-
-
0022272179
-
Some reactions and properties of nitro radical-anions important in biology and medicine
-
Wardman P. Some reactions and properties of nitro radical-anions important in biology and medicine. Environ Health Perspect. 1985; 64: 309-20.
-
(1985)
Environ Health Perspect
, vol.64
, pp. 309-320
-
-
Wardman, P.1
-
46
-
-
0029012868
-
Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids
-
Gross MW, Karbach U, Groebe K, Franko AJ, Mueller-Klieser W. Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int J Cancer. 1995; 61: 567-73.
-
(1995)
Int J Cancer
, vol.61
, pp. 567-573
-
-
Gross, M.W.1
Karbach, U.2
Groebe, K.3
Franko, A.J.4
Mueller-Klieser, W.5
-
47
-
-
0023635532
-
Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro
-
Franko AJ, Koch CJ, Garrecht BM, Sharplin J, Hughes D. Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro. Cancer Res. 1987; 47: 5367-76.
-
(1987)
Cancer Res
, vol.47
, pp. 5367-5376
-
-
Franko, A.J.1
Koch, C.J.2
Garrecht, B.M.3
Sharplin, J.4
Hughes, D.5
-
48
-
-
0019418024
-
Structure-pharmacokinetic relationships for misonidazole analogues in mice
-
Workman P, Brown JM. Structure-pharmacokinetic relationships for misonidazole analogues in mice. Cancer Chemother Pharmacol. 1981; 6: 39-49.
-
(1981)
Cancer Chemother Pharmacol
, vol.6
, pp. 39-49
-
-
Workman, P.1
Brown, J.M.2
-
49
-
-
0018848562
-
Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole
-
Brown JM, Workman P. Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole. Radiat Res. 1980; 82: 171-90.
-
(1980)
Radiat Res
, vol.82
, pp. 171-190
-
-
Brown, J.M.1
Workman, P.2
-
50
-
-
0021846974
-
The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues
-
Watts ME, Jones NR. The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues. Int J Radiat Biol Relat Stud Phys Chem Med. 1985; 47: 645-53.
-
(1985)
Int J Radiat Biol Relat Stud Phys Chem Med
, vol.47
, pp. 645-653
-
-
Watts, M.E.1
Jones, N.R.2
-
51
-
-
30544449463
-
A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker
-
Kleiter MM, Thrall DE, Malarkey DE et al. A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker. Int J Radiat Oncol Biol Phys. 2006; 64: 592-602.
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.64
, pp. 592-602
-
-
Kleiter, M.M.1
Thrall, D.E.2
Malarkey, D.E.3
-
52
-
-
0036895572
-
Orally administered pimonidazole to label hypoxic tumor cells
-
Bennewith KL, Raleigh JA, Durand RE. Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 2002; 62: 6827-30.
-
(2002)
Cancer Res
, vol.62
, pp. 6827-6830
-
-
Bennewith, K.L.1
Raleigh, J.A.2
Durand, R.E.3
-
55
-
-
0031008710
-
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime
-
Azuma C, Raleigh JA, Thrall DE. Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime. Radiat Res. 1997; 148: 35-42.
-
(1997)
Radiat Res
, vol.148
, pp. 35-42
-
-
Azuma, C.1
Raleigh, J.A.2
Thrall, D.E.3
-
57
-
-
0025650261
-
Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules
-
Raleigh JA, Koch CJ. Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem Pharmacol. 1990; 40: 2457-64.
-
(1990)
Biochem Pharmacol
, vol.40
, pp. 2457-2464
-
-
Raleigh, J.A.1
Koch, C.J.2
-
58
-
-
52449099235
-
Correlation of [18F]FMISO autoradiography and pimonodazole immunohistochemistry in human head and neck carcinoma xenografts
-
Troost EG, Laverman P, Philippens ME et al. Correlation of [18F]FMISO autoradiography and pimonodazole immunohistochemistry in human head and neck carcinoma xenografts. Eur J Nucl Med Mol Imaging. 2008; 35: 1803-11.
-
(2008)
Eur J Nucl Med Mol Imaging
, vol.35
, pp. 1803-1811
-
-
Troost, E.G.1
Laverman, P.2
Philippens, M.E.3
-
59
-
-
39449090004
-
Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies
-
Bache M, Kappler M, Said HM, Staab A, Vordermark D. Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies. Curr Med Chem. 2008; 15: 322-38.
-
(2008)
Curr Med Chem
, vol.15
, pp. 322-338
-
-
Bache, M.1
Kappler, M.2
Said, H.M.3
Staab, A.4
Vordermark, D.5
-
60
-
-
31844436258
-
EF5 binding and clinical outcome in human soft tissue sarcomas
-
Evans SM, Fraker D, Hahn SM et al. EF5 binding and clinical outcome in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2006; 64: 922-7.
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.64
, pp. 922-927
-
-
Evans, S.M.1
Fraker, D.2
Hahn, S.M.3
-
61
-
-
57149111715
-
18F-EF5: A new PET tracer for imaging hypoxia in head and neck cancer
-
Komar G, Seppanen M, Eskola O et al. 18F-EF5: A new PET tracer for imaging hypoxia in head and neck cancer. J Nucl Med. 2008; 49: 1944-51.
-
(2008)
J Nucl Med
, vol.49
, pp. 1944-1951
-
-
Komar, G.1
Seppanen, M.2
Eskola, O.3
-
62
-
-
34249951502
-
Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography
-
Yapp DT, Woo J, Kartono A et al. Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography. BJU Int. 2007; 99: 1154-60.
-
(2007)
BJU Int
, vol.99
, pp. 1154-1160
-
-
Yapp, D.T.1
Woo, J.2
Kartono, A.3
-
64
-
-
0036087269
-
The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia
-
Engelhardt EL, Schneider RF, Seeholzer SH, Stobbe CC, Chapman JD. The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia. J Nucl Med. 2002; 43: 837-50.
-
(2002)
J Nucl Med
, vol.43
, pp. 837-850
-
-
Engelhardt, E.L.1
Schneider, R.F.2
Seeholzer, S.H.3
Stobbe, C.C.4
Chapman, J.D.5
-
65
-
-
0030811565
-
Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential
-
Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 1997; 38: 1155-60.
-
(1997)
J Nucl Med
, vol.38
, pp. 1155-1160
-
-
Fujibayashi, Y.1
Taniuchi, H.2
Yonekura, Y.3
Ohtani, H.4
Konishi, J.5
Yokoyama, A.6
-
66
-
-
34447504294
-
PET imaging of tumour hypoxia
-
Padhani A. PET imaging of tumour hypoxia. Cancer Imaging. 2006; 6: S117-21.
-
(2006)
Cancer Imaging
, vol.6
-
-
Padhani, A.1
-
67
-
-
34848893337
-
Hypoxia positron emission tomography imaging with 18F-fluoromisonidazole
-
Lee ST, Scott AM. Hypoxia positron emission tomography imaging with 18F-fluoromisonidazole. Semin Nucl Med. 2007; 37: 451-61.
-
(2007)
Semin Nucl Med
, vol.37
, pp. 451-461
-
-
Lee, S.T.1
Scott, A.M.2
-
68
-
-
0025221111
-
Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumours by 1H/19F magnetic resonance spectroscopy
-
Jin GY, Li SJ, Moulder JE, Raleigh JA. Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumours by 1H/19F magnetic resonance spectroscopy. Int J Radiat Biol. 1990; 58: 1025-34.
-
(1990)
Int J Radiat Biol
, vol.58
, pp. 1025-1034
-
-
Jin, G.Y.1
Li, S.J.2
Moulder, J.E.3
Raleigh, J.A.4
-
69
-
-
34250733045
-
In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors
-
Procissi D, Claus F, Burgman P et al. In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors. Clin Cancer Res. 2007; 13: 3738-47.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3738-3747
-
-
Procissi, D.1
Claus, F.2
Burgman, P.3
-
70
-
-
10044287303
-
Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors
-
Salmon HW, Siemann DW. Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors. Radiother Oncol. 2004; 73: 359-66.
-
(2004)
Radiother Oncol
, vol.73
, pp. 359-366
-
-
Salmon, H.W.1
Siemann, D.W.2
-
73
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999; 399: 271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
74
-
-
0036531825
-
Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells
-
Harada H, Hiraoka M, Kizaka-Kondoh S. Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res. 2002; 62: 2013-18.
-
(2002)
Cancer Res
, vol.62
, pp. 2013-2018
-
-
Harada, H.1
Hiraoka, M.2
Kizaka-Kondoh, S.3
-
75
-
-
27244433455
-
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
-
Harada H, Kizaka-Kondoh S, Hiraoka M. Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging. 2005; 4: 182-93.
-
(2005)
Mol Imaging
, vol.4
, pp. 182-193
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
76
-
-
33749327178
-
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1α containing Pro564
-
Harada H, Kizaka-Kondoh S, Hiraoka M. Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1α containing Pro564. FEBS Lett. 2006; 580: 5718-22.
-
(2006)
FEBS Lett
, vol.580
, pp. 5718-5722
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
77
-
-
36749029349
-
Significance of HIF-1-active cells in angiogenesis and radioresistance
-
Harada H, Kizaka-Kondoh S, Li G et al. Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene. 2007; 26: 7508-16.
-
(2007)
Oncogene
, vol.26
, pp. 7508-7516
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Li, G.3
-
78
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
Moeller BJ, Dreher MR, Rabbani ZN et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell. 2005; 8: 99-110.
-
(2005)
Cancer Cell
, vol.8
, pp. 99-110
-
-
Moeller, B.J.1
Dreher, M.R.2
Rabbani, Z.N.3
-
79
-
-
34548446807
-
Identifying and targeting hypoxia in head and neck cancer: A brief overview of current approaches
-
Le QT. Identifying and targeting hypoxia in head and neck cancer: A brief overview of current approaches. Int J Radiat Oncol Biol Phys. 2007; 69: S56-8.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.69
-
-
Le, Q.T.1
-
80
-
-
34248359065
-
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
-
Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci USA. 2007; 104: 5431-6.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5431-5436
-
-
Parmar, K.1
Mauch, P.2
Vergilio, J.A.3
Sackstein, R.4
Down, J.D.5
-
81
-
-
33644764902
-
Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts
-
Huxham LA, Kyle AH, Baker JH, McNicol KL, Minshinton AI. Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts. Radiother Oncol. 2006; 78: 138-45.
-
(2006)
Radiother Oncol
, vol.78
, pp. 138-145
-
-
Huxham, L.A.1
Kyle, A.H.2
Baker, J.H.3
McNicol, K.L.4
Minshinton, A.I.5
|