Imaging Hypoxia in Xenografted and Murine Tumors With 18F-Fluoroazomycin Arabinoside: A Comparative Study Involving microPET, Autoradiography, Po2-Polarography, and Fluorescence Microscopy

International Journal of Radiation Oncology Biology Physics

Volumn 70, Issue 4, 2008, Pages 1202-1212

  Busk, Morten ^a   Horsman, Michael R ^a   Jakobsen, Steen ^a   Keiding, Susanne ^a   van der Kogel, Albert J ^b   Bussink, Johan ^b   Overgaard, Jens ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

18F FAZA PET; Autoradiography; Eppendorf; Hypoxia; Immunohistochemistry

Indexed keywords

AUTORADIOGRAPHY; EPPENDORF; HYPOXIA; IMMUNOHISTOCHEMISTRY;

DRUG PRODUCTS; FLUORESCENCE MICROSCOPY; KINETICS; OXYGENATION; PHYSIOLOGY; PIXELS; POLAROGRAPHIC ANALYSIS; POSITRON EMISSION TOMOGRAPHY;

TUMORS;

FLUOROAZOMYCIN ARABINOSIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; FEMALE; FIBROSARCOMA; FLUORESCENCE MICROSCOPY; HYPOXIA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLAROGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANIMALS; AUTORADIOGRAPHY; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; FEMALE; FIBROSARCOMA; FLUORINE RADIOISOTOPES; IMMUNOCOMPROMISED HOST; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C3H; MICE, NUDE; MICROSCOPY, FLUORESCENCE; NITROIMIDAZOLES; OXYGEN; POLAROGRAPHY; POSITRON-EMISSION TOMOGRAPHY; RADIATION-SENSITIZING AGENTS; TRANSPLANTATION, HETEROLOGOUS;

EID: 39749202442     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.11.034     Document Type: Article

References (22)

1. Vaupel P., and Harrison L. Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response. Oncologist 9 Suppl 5 (2004) 4-9
2. Nordsmark M., Bentzen S.M., Rudat V., et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 77 (2005) 18-24
3. Kaanders J.H., Pop L.A., Marres H.A., et al. ARCON: Experience in 215 patients with advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 52 (2002) 769-778
4. Overgaard J., and Horsman M.R. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 6 (1996) 10-21
5. Overgaard J., Hansen H.S., Overgaard M., et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 46 (1998) 135-146
6. Milosevic M., Fyles A., Hedley D., et al. The human tumor microenvironment: Invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 14 (2004) 249-258
7. Williams K.J., Parker C.A., and Stratford I.J. Exogenous and endogenous markers of tumour oxygenation status: Definitive markers of tumour hypoxia?. Adv Exp Med Biol 566 (2005) 285-294
8. 18F-fluoroazomycin arabinoside. J Nucl Med 46 (2005) 106-113
9. 2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys 61 (2005) 1493-1502
10. 18F-FDG microPET studies in mouse tumor xenografts. J Nucl Med 48 (2007) 602-607
11. 18FMISO): A comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors. Nucl Med Biol 30 (2003) 317-326
12. Hockel M., Schlenger K., Aral B., et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56 (1996) 4509-4515
13. 2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother Oncol 53 (1999) 99-104
14. Okunieff P., Dunphy E.P., Hoeckel M., et al. The role of oxygen tension distribution on the radiation response of human breast carcinoma. Adv Exp Med Biol 345 (1994) 485-492
15. 18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography. Br J Cancer 90 (2004) 2232-2242
16. 2 electrode measurements: Influence of tumour volume and carbogen breathing. Acta Oncol 41 (2002) 304-312
17. 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours. Radiother Oncol 67 (2003) 339-344
18. 18F]-2-fluoro-2′-deoxyglucose). An appraisal of radiotherapeutically relevant hypoxia. Strahlenther Onkol 180 (2004) 616-622
19. 99MTC]HL-91: Correlation with microelectrode measurements. J Nucl Med 42 (2001) 337-344
20. Pugachev A., Ruan S., Carlin S., et al. Dependence of FDG uptake on tumor microenvironment. Int J Radiat Oncol Biol Phys 62 (2005) 545-553
21. Wijffels K.I., Kaanders J.H., Rijken P.F., et al. Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas. Br J Cancer 83 (2000) 674-683
22. Rasey J.S., Nelson N.J., Chin L., et al. Characteristics of the binding of labeled fluoromisonidazole in cells. in vitro. Radiat Res 122 (1990) 301-308