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Volumn 1, Issue 1, 2000, Pages 25-29

The role of hypoxia-activated prodrugs in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; NITROIMIDAZOLE DERIVATIVE; OXIDE; PRODRUG; QUINONE DERIVATIVE;

EID: 0034285733     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(00)00006-1     Document Type: Review
Times cited : (143)

References (28)
  • 1
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer chemotherapy
    • Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer chemotherapy. Cancer Res. 58:1998;1405-1416.
    • (1998) Cancer Res , vol.58 , pp. 1405-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 2
    • 0031105658 scopus 로고    scopus 로고
    • Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors
    • Baish JW, Netti PA, Jain RK. Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. Microvasc Res. 53:1997;128-141.
    • (1997) Microvasc Res , vol.53 , pp. 128-141
    • Baish, J.W.1    Netti, P.A.2    Jain, R.K.3
  • 3
    • 0030069889 scopus 로고
    • Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitisers
    • Overgaard J, Horsmann JR. Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitisers. Sem in Radiat Oncol. 6:1969;10-21.
    • (1969) Sem in Radiat Oncol , vol.6 , pp. 10-21
    • Overgaard, J.1    Horsmann, J.R.2
  • 4
    • 0026417645 scopus 로고
    • Therapeutic advantage of hypoxic cells in tumors: A theoretical study
    • Brown JM, Koong A. Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J Natl Cancer Inst. 83:1991;178-185.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 178-185
    • Brown, J.M.1    Koong, A.2
  • 5
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
    • Lash CJ, Li AE, Rutland M, et al. Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. Br J Cancer. 78:1998;439-445.
    • (1998) Br J Cancer , vol.78 , pp. 439-445
    • Lash, C.J.1    Li, A.E.2    Rutland, M.3
  • 6
    • 0027219332 scopus 로고
    • Bioreducible mustards - A paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
    • Denny WA, Wilson WR. Bioreducible mustards - a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Metastasis Rev. 12:1993;135-151.
    • (1993) Cancer Metastasis Rev , vol.12 , pp. 135-151
    • Denny, W.A.1    Wilson, W.R.2
  • 7
    • 0029884764 scopus 로고    scopus 로고
    • Recent developments in the design of bioreductive drugs
    • Denny WA, Wilson WR, Hay MP. Recent developments in the design of bioreductive drugs. Br J Cancer. 74:(suppl 27):1996;32-38.
    • (1996) Br J Cancer , vol.74 , Issue.SUPPL. 27 , pp. 32-38
    • Denny, W.A.1    Wilson, W.R.2    Hay, M.P.3
  • 8
    • 0031969730 scopus 로고    scopus 로고
    • Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer
    • Breider MA, Pilcher GD, Graziano MJ, et al. Retinal degeneration in rats induced by CI-1010, a 2-nitroimidazole radiosensitizer. Toxicol Pathol. 26:1998;234-239.
    • (1998) Toxicol Pathol , vol.26 , pp. 234-239
    • Breider, M.A.1    Pilcher, G.D.2    Graziano, M.J.3
  • 9
    • 0033516908 scopus 로고    scopus 로고
    • A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro- 3H-benz[e]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT
    • Hay MP, Sykes BM, Denny WA, et al. A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro- 3H-benz[e]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT. Bioorg Med Chem Lett. 15:1999;2237-2242.
    • (1999) Bioorg Med Chem Lett , vol.15 , pp. 2237-2242
    • Hay, M.P.1    Sykes, B.M.2    Denny, W.A.3
  • 10
    • 0343530603 scopus 로고    scopus 로고
    • Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
    • Lee J, Siemann DW, Koch CJ, et al. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int J Cancer. 67:1996;372-388.
    • (1996) Int J Cancer , vol.67 , pp. 372-388
    • Lee, J.1    Siemann, D.W.2    Koch, C.J.3
  • 11
    • 0027182862 scopus 로고
    • The bioactivation of CB-1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
    • Knox RJ, Friedlos F, Boland MP. The bioactivation of CB-1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). Cancer Metastasis Rev. 12:1993;195-212.
    • (1993) Cancer Metastasis Rev , vol.12 , pp. 195-212
    • Knox, R.J.1    Friedlos, F.2    Boland, M.P.3
  • 12
    • 0031875844 scopus 로고    scopus 로고
    • Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase
    • Belcourt MF, Hodnick WF, Rockwell S, et al. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase. Adv Enzyme Reg. 38:1998;111-133.
    • (1998) Adv Enzyme Reg , vol.38 , pp. 111-133
    • Belcourt, M.F.1    Hodnick, W.F.2    Rockwell, S.3
  • 13
    • 0031278015 scopus 로고    scopus 로고
    • The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
    • Tomasz M, Palom Y. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. Pharmacol Ther. 76:1997;73-87.
    • (1997) Pharmacol Ther , vol.76 , pp. 73-87
    • Tomasz, M.1    Palom, Y.2
  • 14
    • 12644264303 scopus 로고    scopus 로고
    • Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck
    • Haffty BG, Son YH, Wilson LD, et al. Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck. Radiat Oncol Invest. 5:1997;235-245.
    • (1997) Radiat Oncol Invest , vol.5 , pp. 235-245
    • Haffty, B.G.1    Son, Y.H.2    Wilson, L.D.3
  • 15
    • 0030710552 scopus 로고    scopus 로고
    • Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9
    • Bailey SM, Wyatt MD, Friedlos F, et al. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9. Br J Cancer. 76:1997;1596-1603.
    • (1997) Br J Cancer , vol.76 , pp. 1596-1603
    • Bailey, S.M.1    Wyatt, M.D.2    Friedlos, F.3
  • 16
    • 0033975257 scopus 로고    scopus 로고
    • Phase I trial with weekly EO9, a novel bioreductive alkylating indoloquinone, by the EORTC Early Clinical Study Group (ECSG)
    • Aamdal S, Lund B, Koier I, et al. Phase I trial with weekly EO9, a novel bioreductive alkylating indoloquinone, by the EORTC Early Clinical Study Group (ECSG). Cancer Chemother Pharmacol. 45:2000;85-88.
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 85-88
    • Aamdal, S.1    Lund, B.2    Koier, I.3
  • 17
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy - eighteenth Bruce F Cain Memorial Award lecture
    • Brown JM. The hypoxic cell: a target for selective cancer therapy - eighteenth Bruce F Cain Memorial Award lecture. Cancer Res. 59:1999;5863-5870.
    • (1999) Cancer Res , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 18
    • 0033607196 scopus 로고    scopus 로고
    • Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1′-radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions
    • Hwang JT, Greenberg MM, Fuchs T, et al. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1′-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions. Biochemistry. 38:1999;14248-14255.
    • (1999) Biochemistry , vol.38 , pp. 14248-14255
    • Hwang, J.T.1    Greenberg, M.M.2    Fuchs, T.3
  • 19
    • 0031785201 scopus 로고    scopus 로고
    • Extravascular diffusion of tirapazamine: Effect of metabolic consumption assessed using the multicellular layer model
    • Hicks KO, Fleming Y, Siim BG, et al. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int J Radiat Oncol Biol Phys. 42:1998;641-649.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 641-649
    • Hicks, K.O.1    Fleming, Y.2    Siim, B.G.3
  • 20
    • 0031743190 scopus 로고    scopus 로고
    • Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: A phase II study
    • Lee DJ, Trotti A, Spencer S, et al. Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase II study. Int J Radiat Oncol Biol Phys. 42:1998;811-815.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 811-815
    • Lee, D.J.1    Trotti, A.2    Spencer, S.3
  • 21
    • 0033063810 scopus 로고    scopus 로고
    • Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
    • Kovacs MS, Hocking DJ, Evans JW, et al. Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin. Br J Cancer. 80:1999;1245-1251.
    • (1999) Br J Cancer , vol.80 , pp. 1245-1251
    • Kovacs, M.S.1    Hocking, D.J.2    Evans, J.W.3
  • 22
    • 0031809546 scopus 로고    scopus 로고
    • Tirapazamine-cisplatin: The synergy
    • Gatzemeier U, Rodriguez G, Treat J, et al. Tirapazamine-cisplatin: the synergy. Br J Cancer. 77:(suppl 4):1998;15-17.
    • (1998) Br J Cancer , vol.77 , Issue.SUPPL. 4 , pp. 15-17
    • Gatzemeier, U.1    Rodriguez, G.2    Treat, J.3
  • 23
    • 0031734636 scopus 로고    scopus 로고
    • Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: A phase II study
    • Treat J, Johnson E, Langer C, et al. Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: a phase II study. J Clin Oncol. 16:1998;3524-3527.
    • (1998) J Clin Oncol , vol.16 , pp. 3524-3527
    • Treat, J.1    Johnson, E.2    Langer, C.3
  • 24
    • 0031742538 scopus 로고
    • Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug
    • Raleigh SM, Wanogho E, Burke MD, et al. Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. Int J Radiat Oncol Biol Phys. 42:1988;763-767.
    • (1988) Int J Radiat Oncol Biol Phys , vol.42 , pp. 763-767
    • Raleigh, S.M.1    Wanogho, E.2    Burke, M.D.3
  • 25
    • 0028650760 scopus 로고
    • Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs
    • Patterson LH, Craven MR, Fisher GR, et al. Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs. Oncol Res. 6:1994;533-538.
    • (1994) Oncol Res , vol.6 , pp. 533-538
    • Patterson, L.H.1    Craven, M.R.2    Fisher, G.R.3
  • 26
    • 0029054994 scopus 로고
    • AQ4N; An alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo
    • McKeown SR, Hejmadi MV, McIntyre IA, et al. AQ4N; an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo. Br J Cancer. 72:1995;76-81.
    • (1995) Br J Cancer , vol.72 , pp. 76-81
    • McKeown, S.R.1    Hejmadi, M.V.2    McIntyre, I.A.3
  • 27
    • 0027160629 scopus 로고
    • Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins - synthesis and evaluation of cobalt(III) complexes of bidentate mustards
    • Ware DC, Palmer BD, Wilson WR, et al. Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins - synthesis and evaluation of cobalt(III) complexes of bidentate mustards. J Med Chem. 36:1993;1839-1846.
    • (1993) J Med Chem , vol.36 , pp. 1839-1846
    • Ware, D.C.1    Palmer, B.D.2    Wilson, W.R.3
  • 28
    • 0029931345 scopus 로고    scopus 로고
    • Pulse radiolysis studies on the mechanism of hypoxia-selective cytotoxicity of the cobalt(III)-nitrogen mustard complex SN 24771
    • Anderson RF, Denny WA, Ware DC, et al. Pulse radiolysis studies on the mechanism of hypoxia-selective cytotoxicity of the cobalt(III)-nitrogen mustard complex SN 24771. Br J Cancer. 74:(suppl 27):1996;48-51.
    • (1996) Br J Cancer , vol.74 , Issue.SUPPL. 27 , pp. 48-51
    • Anderson, R.F.1    Denny, W.A.2    Ware, D.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.