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Volumn 580, Issue 24, 2006, Pages 5718-5722

Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1α containing Pro564

Author keywords

Apoptosis; Caspase 3; Hypoxia; Hypoxia inducible factor 1; von Hippel Lindau

Indexed keywords

CASPASE 3; HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCASPASE 3; PROLINE; VON HIPPEL LINDAU PROTEIN;

EID: 33749327178     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.09.025     Document Type: Article
Times cited : (27)

References (25)
  • 1
    • 0033233243 scopus 로고    scopus 로고
    • Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    • Semenza G.L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15 (1999) 551-578
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 2
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza G.L., and Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12 (1992) 5447-5454
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 3
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang L.E., Gu J., Schau M., and Bunn H.F. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 5 (1998) 7987-7992
    • (1998) Proc. Natl. Acad. Sci. USA , vol.5 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 4
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio P.J., Wilson W.J., O'Brien S., Makino Y., and Poellinger L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J. Biol. Chem. 274 (1999) 6519-6525
    • (1999) J. Biol. Chem. , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 5
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R.K., and McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294 (2001) 1337-1340
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 8
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M., Park C.W., Ivan M., Hoffman M.A., Kim T.Y., Huang L.E., Pavletich N., Chau V., and Kaelin W.G. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2 (2000) 423-427
    • (2000) Nat. Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3    Hoffman, M.A.4    Kim, T.Y.5    Huang, L.E.6    Pavletich, N.7    Chau, V.8    Kaelin, W.G.9
  • 9
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • Kamura T., Sato S., Iwai K., Czyzyk-Krzeska M., Conaway R.C., and Conaway J.W. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 97 (2000) 10430-10435
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzyk-Krzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 10
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto K., Makino Y., Pereira T., and Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19 (2000) 4298-4309
    • (2000) EMBO J. , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 11
    • 0036531825 scopus 로고    scopus 로고
    • Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells
    • Harada H., Hiraoka M., and Kizaka-Kondoh S. Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res. 62 (2002) 2013-2018
    • (2002) Cancer Res. , vol.62 , pp. 2013-2018
    • Harada, H.1    Hiraoka, M.2    Kizaka-Kondoh, S.3
  • 12
    • 0347029631 scopus 로고    scopus 로고
    • Tumor hypoxia: a target for selective cancer therapy
    • Kizaka-Kondoh S., Inoue M., Harada H., and Hiraoka M. Tumor hypoxia: a target for selective cancer therapy. Cancer Sci. 94 (2003) 1021-1028
    • (2003) Cancer Sci. , vol.94 , pp. 1021-1028
    • Kizaka-Kondoh, S.1    Inoue, M.2    Harada, H.3    Hiraoka, M.4
  • 13
    • 12344276974 scopus 로고    scopus 로고
    • Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites
    • Inoue M., Mukai M., Hamanaka Y., Tatsuta M., Hiraoka M., and Kizaka-Kondoh S. Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites. Int. J. Oncol. 25 (2004) 713-720
    • (2004) Int. J. Oncol. , vol.25 , pp. 713-720
    • Inoue, M.1    Mukai, M.2    Hamanaka, Y.3    Tatsuta, M.4    Hiraoka, M.5    Kizaka-Kondoh, S.6
  • 14
    • 27244433455 scopus 로고    scopus 로고
    • Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
    • Harada H., Kizaka-Kondoh S., and Hiraoka M. Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol. Imaging 4 (2005) 182-193
    • (2005) Mol. Imaging , vol.4 , pp. 182-193
    • Harada, H.1    Kizaka-Kondoh, S.2    Hiraoka, M.3
  • 15
    • 0027973061 scopus 로고
    • CPP32, a novel human apoptotic protein with homology toaenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme
    • Fernandes-Alnemri T., Litwack G., and Alnemri E.S. CPP32, a novel human apoptotic protein with homology toaenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269 (1994) 30761-30764
    • (1994) J. Biol. Chem. , vol.269 , pp. 30761-30764
    • Fernandes-Alnemri, T.1    Litwack, G.2    Alnemri, E.S.3
  • 16
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O., Kibel A., Gray S., and Kaelin Jr. W.G. Tumour suppression by the human von Hippel-Lindau gene product. Nat. Med. 1 (1995) 822-826
    • (1995) Nat. Med. , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin Jr., W.G.4
  • 17
    • 3342956466 scopus 로고    scopus 로고
    • Caspase-9 regulation: an update
    • Johnson C.R., and Jarvis W.D. Caspase-9 regulation: an update. Apoptosis 9 (2004) 423-427
    • (2004) Apoptosis , vol.9 , pp. 423-427
    • Johnson, C.R.1    Jarvis, W.D.2
  • 18
    • 13644258650 scopus 로고    scopus 로고
    • Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways
    • Nagarajah N.S., Vigneswaran N., and Zacharias W. Hypoxia-mediated apoptosis in oral carcinoma cells occurs via two independent pathways. Mol. Cancer 3 (2004) 38
    • (2004) Mol. Cancer , vol.3 , pp. 38
    • Nagarajah, N.S.1    Vigneswaran, N.2    Zacharias, W.3
  • 19
    • 0038714732 scopus 로고    scopus 로고
    • Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription
    • Mirnezami A.H., Campbell S.J., Darley M., Primrose J.N., Johnson P.W., and Blaydes J.P. Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription. Curr. Biol. 13 (2003) 1234-1239
    • (2003) Curr. Biol. , vol.13 , pp. 1234-1239
    • Mirnezami, A.H.1    Campbell, S.J.2    Darley, M.3    Primrose, J.N.4    Johnson, P.W.5    Blaydes, J.P.6
  • 20
    • 0037151032 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
    • Zhu Y., Mao X.O., Sun Y., Xia Z., and Greenberg D.A. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J. Biol. Chem. 277 (2002) 22909-22914
    • (2002) J. Biol. Chem. , vol.277 , pp. 22909-22914
    • Zhu, Y.1    Mao, X.O.2    Sun, Y.3    Xia, Z.4    Greenberg, D.A.5
  • 21
    • 0033572417 scopus 로고    scopus 로고
    • Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
    • Alarcon R., Koumenis C., Geyer R.K., Maki C.G., and Giaccia A.J. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res. 59 (1999) 6046-6051
    • (1999) Cancer Res. , vol.59 , pp. 6046-6051
    • Alarcon, R.1    Koumenis, C.2    Geyer, R.K.3    Maki, C.G.4    Giaccia, A.J.5
  • 22
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber T.G., Peterson J.F., Tsai M., Monica K., Fornace Jr. A.J., and Giaccia A.J. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14 (1994) 6264-6277
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace Jr., A.J.5    Giaccia, A.J.6
  • 24
    • 0031743945 scopus 로고    scopus 로고
    • Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
    • Rothmann T., Hengstermann A., Whitaker N.J., Scheffner M., and zur Hausen H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol. 72 (1998) 9470-9478
    • (1998) J. Virol. , vol.72 , pp. 9470-9478
    • Rothmann, T.1    Hengstermann, A.2    Whitaker, N.J.3    Scheffner, M.4    zur Hausen, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.