Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors

Radiotherapy and Oncology

Volumn 73, Issue 3, 2004, Pages 359-366

  Salmon, Howard W ^a   Siemann, Dietmar W ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Hypoxic tumor cells; Magnetic resonance spectroscopy; Molecular probes; Nitroimidazoles; Solid tumors

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; CELL MARKER; 2-(2-NITRO-1H-IMIDAZOL-1-YL)-N-(2,2,3,3,3-PENTAFLUOROPROPYL)ACETAMIDE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; DIAGNOSTIC AGENT; DRUG DERIVATIVE; ETANIDAZOLE; FLUORINATED HYDROCARBON; FLUORINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; FEMALE; MAGNET; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOLID TUMOR; SPECTROMETER; TUMOR CELL; ANIMAL; ANIMAL DISEASE; METHODOLOGY; PATHOPHYSIOLOGY; SARCOMA; SCINTISCANNING;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CELL HYPOXIA; ETANIDAZOLE; FEMALE; FLUORINE RADIOISOTOPES; HYDROCARBONS, FLUORINATED; MAGNETIC RESONANCE SPECTROSCOPY; MICE; SARCOMA;

EID: 10044287303     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.07.018     Document Type: Article

References (37)

1. E.O. Aboagye, R.J. Maxwell, and A.B. Kelson Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1- imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia Cancer Res 57 1997 3314 3318
2. D.M. Brizel, G.L. Rosner, and J. Harrelson Pretreatment oxygenation profiles of human soft tissue sarcomas Int J Radiat Oncol Biol Phys 30 1994 635 642
3. D.M. Brizel, S.P. Scully, and J.M. Harrelson Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res 56 1996 941 943
4. D.M. Brizel, G.S. Sibley, and L.R. Prosnitz Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck Int J Radiat Oncol Biol Phys 38 1997 285 289
5. J.M. Brown, and A.J. Giaccia The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Res 58 1998 1408 1416
6. J.D. Chapman Measurement of tumor hypoxia by invasive and non-invasive procedures: a review of recent clinical studies Radiother Oncol 20 1991 13 19
7. J.D. Chapman, K. Baer, and J. Lee Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells Cancer Res 43 1983 1523 1528
8. K. De Jaeger, M.C. Kavanagh, and R.P. Hill Relationship of hypoxia to metastatic ability in rodent tumours Br J Cancer 84 2001 1280 1285
9. S.M. Evans, S.M. Hahn, and D.P. Magarelli Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation Am J Clin Oncol 24 2001 467 472
10. S.M. Evans, B. Joiner, and W.T. Jenkins Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol- 1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] Br J Cancer 72 1995 875 882
11. A.J. Giaccia Hypoxic stress proteins: survival of the fittest Semin Radiat Oncol 6 1996 46 58
12. T.G. Graeber, C. Osmanian, and T. Jacks Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours Nature 379 1996 88 91
13. R.P. Hill Tumor progression: potential role of unstable genomic changes Cancer Metastasis Rev 9 1990 137 147
14. M. Hockel, C. Knoop, and K. Schlenger Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix Radiother Oncol 26 1993 45 50
15. C.J. Koch, and S.M. Evans Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles Adv Exp Med Biol 510 2003 285 292
16. C.J. Koch, S.M. Evans, and E.M. Lord Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide]: analysis of drug adducts by fluorescent antibodies vs. bound radioactivity Br J Cancer 72 1995 869 874
17. C.J. Koch, S.M. Hahn, and K. Rockwell Jr Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles Cancer Chemother Pharmacol 48 2001 177 187
18. W.J. Koh, J.S. Rasey, and M.L. Evans Imaging of hypoxia in human tumors with [F-18] fluoromisonidazole Int J Radiat Oncol Biol Phys 22 1992 199 212
19. L. Kwock, M. Gill, H.L. McMurry, and W. Beckman Evaluation of a fluorinated 2-nitroimidazole binding to hypoxic cells in tumor-bearing rats by 19F magnetic resonance spectroscopy and immunohistochemistry Radiat Res 129 1992 71 78
20. J. Lee, D.W. Siemann, and C.J. Koch Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts Int J Cancer 67 1996 372 378
21. G. Jin, S. Li, J.E. Moulder, and J.A. Raleigh Dynamic measurements of hexafluoromisonidazole (CCI-103F) retention in mouse tumors by 1H/19F magnetic resonance spectroscopy Int J Radiat Biol 58 1990 1025 1034
22. A.S. Ljungkvist, J. Bussink, and P.F. Rijken Changes in tumor hypoxia measured with a double hypoxic marker technique Int J Radiat Oncol Biol Phys 48 2000 1529 1538
23. R.J. Maxwell, P. Workman, and J.R. Giffiths Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo Int J Radiat Oncol Biol Phys 6 1989 925 929
24. M. Nordsmark, J. Loncaster, and C. Aquino-Parsons Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas Radiother Oncol 67 2003 35 44
25. M. Nordsmark, M. Overgaard, and J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother Oncol 41 1996 31 39
26. J.A. Raleigh, S.C. Chou, and G.E. Arteel Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors Radiat Res 151 1999 580 589
27. J.A. Raleigh, A.J. Franko, and D.A. Kelly Development of an in vivo 19F magnetic resonance method for measuring oxygen deficiency in tumors Magn Reson Med 22 1991 451 466
28. J.A. Raleigh, A.J. Franko, E.O. Treiber, J.A. Lunt, and P.S. Allen Covalent binding of a fluorinated 2-nitroimidazole to EMT-6 tumours in Balb/C mice: Detection by F-19 nuclear magnetic resonance at 2.35 T Int J Radiat Oncol Biol Phys 12 1986 1243 1245
29. J.A. Raleigh, A.J. Franko, and C.J. Koch Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label Br J Cancer 51 1985 229 235
30. J.S. Rasey, Z. Grunbaum, and S. Magee Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells Radiat Res 111 1987 292 304
31. B.M. Seddon, G.S. Payne, and L. Simmons A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy Clin Cancer Res 9 2003 5101 5112
32. D.W. Siemann The tumor microenvironment: a double-edged sword Int J Radiat Oncol Biol Phys 42 1998 697 699
33. D.W. Siemann, I.M. Johansen, and M.R. Horsman Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph Int J Radiat Oncol Biol Phys 40 1998 1171 1176
34. H.B. Stone, J.M. Brown, and T.L. Phillips Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland Radiat Res 136 1993 422 434
35. R.C. Urtasum, M.B. Parliment, and A.J. McEwan Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside Br J Cancer 74 1996 S209 S212
36. P. Vaupel, F. Kallinowski, and P. Okunieff Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res 49 1989 6449 6465
37. S.D. Young, R.S. Marshall, and R.P. Hill Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells Proc Natl Acad Sci USA 85 1988 9533 9537