Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors

Radiation Research

Volumn 151, Issue 5, 1999, Pages 580-589

  Raleigh, J A ^a   Chou, S C ^a   Arteel, G E ^a   Horsman, M R ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOGEN; HYDRALAZINE; HYPOXYPROBE 1; OXYGEN; PIMONIDAZOLE; UNCLASSIFIED DRUG;

AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; BREATHING; CLAMP; CONTROLLED STUDY; DRUG BINDING; ELECTRODE; FEMALE; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; OXYGEN BREATHING; OXYGEN TENSION; OXYGENATION; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOBIOLOGY; TUMOR BLOOD FLOW;

ANIMALS; BIOLOGICAL MARKERS; CELL HYPOXIA; ELECTRODES; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; MICE, INBRED DBA; NITROIMIDAZOLES; OXYGEN; RADIATION-SENSITIZING AGENTS;

ANIMALIA;

EID: 0032801526     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3580034     Document Type: Article

References (60)

1. M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer and P. Vaupel, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509-4515 (1996).
2. D. M. Brizel, G. S. Sibley, L. R. Prosnitz, R. L. Scher and M. W. Dewhirst, Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 38, 285-289 (1997).
3. D. M. Brizel, S. P. Scully, J. M. Harrelson, L. J. Layfield, J. M. Bean, L. R. Prosnit and M. W. Dewhirst, Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56, 941-943 (1996).
4. T. G. Graeber, C. Osmanian, T. Jacks, D. E. Housman, C. J. Koch, S. W. Lowe and A. J. Giaccia, Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91 (1996).
5. A. S. Kennedy, J. A. Raleigh, G. M. Perez, D. P. Calkins, D. E. Thrall, D. B. Novotny and M. A. Varia, Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays. Int. J. Radiat. Oncol. Biol. Phys. 37, 897-905 (1997).
6. M. A. Varia, D. P. Calkins-Adams, L. H. Rinker, A. S. Kennedy, D. B. Novotny, W. C. Fowler and J. A. Raleigh, Pimonidazole: A novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol. Oncol. 71, 270-277 (1998).
7. R. M. Sutherland, W. A. Ausserer, B. J. Murphy and K. R. Laderoute, Tumor hypoxia and heterogeneity: Challenges and opportunities for the future. Semin. Radiat. Oncol. 6, 59-70 (1996).
8. J. A. Raleigh, G. G. Miller, A. J. Franko, C. J. Koch, A. F. Fuciarelli and D. A. Kelly, Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours. Br. J. Cancer 56, 395-400 (1987).
9. J. A. Raleigh, G. G. Miller, A. J. Franko and J. D. Chapman, Immunochemical detection of hypoxia in normal and tumor tissue. U.S. patent no. 5,086,068. February 4, 1992.
10. G. E. Arteel, R. G. Thurman, J. M. Yates and J. A. Raleigh, Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer 72, 889-895 (1995).
11. C. Azuma, J. A. Raleigh and D. E. Thrall, Lifetime of hypoxic cells in spontaneous canine tumors. Radiat. Res. 148, 35-42 (1997).
12. J. A. Raleigh, D. P. Calkins-Adams, L. H. Rinker, C. A. Ballenger, M. C. Weissler, W. C. Fowler, Jr., D. B. Novotny and M. A. Varia, Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. Cancer Res. 58, 3765-3768 (1998).
13. A. A. Khalil, M. R. Horsman, M. Nordsmark, C. Grau and J. Overgaard, Oxygenation status in an experimental murine tumour system. In Tumor Oxygenation (P. W. Vaupel, D. K. Kelleher and M. Günderoth, Eds.), pp. 107-117, Gustav Fischer Verlag, New York, 1995.
14. J. Overgaard, Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. Int. J. Radiat. Oncol. Biol. Phys. 6, 1507-1517 (1980).
15. M. I. Walton, N. M. Bleehen and P. Workman, Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice. Br. J. Cancer 59, 667-673 (1989).
16. J. M. Cline, G. L. Rosner, J. A. Raleigh and D. E. Thrall, Quantification of CCI-103F labeling heterogeneity in canine solid tumors. Int. J. Radiat. Oncol. Biol. Phys. 37, 655-662 (1997).
17. D. E. Thrall, G. L. Rosner, C. Azuma, M. C. McEntee and J. A. Raleigh, Hypoxia marker labeling in tumor biopsies: Quantification of labeling variation and criteria for biopsy sectioning. Radiother. Oncol. 44, 171-176 (1997).
18. M. R. Horsman, D. J. Chaplin and J. Overgaard, Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells. Cancer Res. 50, 7430-7436 (1990).
19. C. Grau, S. M. Bentzen and J. Overgaard, Cytotoxic effect of misonidazole and cyclophosphamide on aerobic and hypoxic cells in a C3H mammary carcinoma in vivo. Br. J. Cancer 61, 61-64 (1990).
20. S. M. Bentzen and C. Grau, Direct estimation of the fraction of hypoxic cells from tumor control data obtained under aerobic and clamped conditions. Int. J. Radiat. Biol. 59, 1435-1440 (1991).
21. J. A. Raleigh, S-C. Chou, L. Tables, S. Suchindran, M. A. Varia and M. R. Horsman, Relationship of hypoxia to metallothionein expression in murine tumors. Int. J. Radiat. Oncol. Biol. Phys. 42, 727-730 (1998).
22. G. G. Miller, M. W. Best, A. J. Franko, C. J. Koch and J. A. Raleigh, Quantitation of hypoxia in multicellular spheroids by video image analysis. Int. J. Radiat. Oncol. Biol. Phys. 16, 949-952 (1989).
23. 19F magnetic resonance method for measuring oxygen deficiency in tumors. Magn. Reson. Med. 22, 451-466 (1991).
24. J. M. Cline, D. E. Thrall, R. L. Page, A. J. Franko and J. A. Raleigh, Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours. Br. J. Cancer 62, 925-931 (1990).
25. J. M. Cline, D. E. Thrall, G. L. Rosner and J. A. Raleigh, Distribution of the hypoxia marker CCI-103F in canine tumors. Int. J. Radiat. Oncol. Biol. Phys. 28, 921-933 (1994).
26. I. A. Raleigh, J. K. La Dine, J. M. Cline and D. E. Thrall, An enzyme-linked immunosorbent assay for hypoxia marker binding in tumours. Br. J. Cancer 69, 66-71 (1994).
27. D. E. Thrall, M. C. McEntee, J. M. Cline and J. A. Raleigh, ELISA quantification of CCI-103F binding in canine tumors prior to and during irradiation. Int. J. Radiat. Oncol. Biol. Phys. 28, 649-659 (1994).
28. J. A. Raleigh, M. W. Dewhirst and D. E. Thrall, Measuring tumor hypoxia. Semin. Radiat. Oncol. 6, 37-45 (1996).
29. J. G. Allen, S. Dische, I. Lenox-Smith, S. L. Malcolm and M. I. Saunders, The pharmacokinetics of a new radiosensitiser, Ro 03-8799 in humans. J. Clin. Pharmacol. 27, 483-489 (1984).
30. J. T. Roberts, N. M. Bleehen, P. Workman and M. I. Walton, A Phase I study of the hypoxic cell radiosensitizer Ro-03-8799. Int. J. Radiat. Oncol. Biol. Phys. 10, 1755-1758 (1984).
31. M. I. Saunders, P. J. Anderson, M. H. Bennett, S. Dische, A. I. Minchinton and M. R. L. Stratford, The clinical testing of Ro 03-8799-pharmacokinetics, toxicology, tissue and tumor concentrations. Int. J. Radiat. Oncol. Biol. Phys. 10, 1759-1763 (1984).
32. G. E. Arteel, J. A. Raleigh, B. U. Bradford and R. G. Thurman, Acute alcohol produces hypoxia directly in rat liver tissue in vivo: Role of Kupffer cells. Am. J. Physiol. 271, G494-G500 (1996).
33. C. E. Arteel, Y. Iimuro, J. A. Raleigh and R. G. Thurman, Chronic enteral alcohol treatment causes hypoxia in rat liver tissue in vivo. Hepatobiology 25, 920-926 (1997).
34. G. E. Arteel, R. G. Thurman, J. M. Yates and J. A. Raleigh, Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur. J. Biochem. 253, 743-750 (1998).
35. R. E. Durand and J. A. Raleigh, Identification of nonproliferating but viable hypoxic tumor cells in vivo. Cancer Res. 58, 3547-3550 (1998).
36. Z. Zhong, G. E. Arteel, H. D. Connor, M. Yin, M. V. Frankenberg, R. F. Stachlewitz, J. A. Raleigh, R. P. Mason and R. G. Thurman, Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine. Am. J. Physiol. 275, F595-F604 (1998).
37. R. P. Mason and J. L. Holtzman, The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. Biochemistry 14, 1626-1632 (1975).
38. E. Perez-Reyes, B. Kalyanaraman and R. P. Mason, The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Mol. Pharmacol. 17, 239-244 (1979).
39. L. M. Cobb, J. Nolan and S. A. Butler, Distribution of pimonidazole and RSU 1069 in tumour and normal tissues. Br. J. Cancer 62, 915-918 (1990).
40. 3H-labelled misonidazole in the tumor-bearing mouse. Int. J. Radiat. Oncol. Biol. Phys. 18, 347-351 (1990).
41. J. A. Raleigh, A. J. Franko, C. J. Koch and J. L. Born, Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label. Br. J. Cancer 51, 229-235 (1985).
42. J. A. Raleigh and C. J. Koch, Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem. Pharmacol. 40, 2457-2464 (1990).
43. A. J. Varghese, Glutathione conjugates of misonidazole. Biochem. Biophys. Res. Commun. 112, 1013-1020 (1983).
44. E. Chacon, C. J. Morrow, A. A. Leon, J. L. Born and B. R. Smith, Regioselective formation of a misonidazole-glutathione conjugate as a function of pH during chemical reduction. Biochem. Pharmacol. 37, 361-363 (1988).
45. J. A. Raleigh and S. F. Liu, Reductive fragmentation of 2-nitroimidazoles in the presence of nitroreductases-glyoxal formation from misonidazole. Biochem. Pharmacol. 32, 1444-1446 (1983).
46. J. A. Raleigh and S. F. Liu, Reductive fragmentation of 2-nitroimidazoles. Amines and aldehydes. Int. J. Radiat. Oncol. Biol. Phys. 10, 1337-1340 (1984).
47. R. J. McClelland, J. R. Fuller, N. E. Seaman, A. M. Rauth and R. Battistell, 2-Hydroxylaminoimidazoles - unstable intermediates in the reduction of 2-nitroimidazoles. Biochem. Pharmacol. 33, 303-309 (1984).
48. M. B. Noss, R. Panicucci, R. A. McClelland and A. M. Rauth, 1-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabilities. Int. J. Radiat. Oncol. Biol. Phys. 16, 1015-1019 (1989).
49. C. F. Chao, L. Ting, J. R. Subjeck and R. J. Johnson, The effect of nitroimidazoles on the oxygen consumption rate and respiratory control ratio of beef heart mitochondria. Int. J. Radiat. Oncol. Biol. Phys. 10, 1391-1394 (1984).
50. M. I. Walton, N. M. Bleehen and P. Workman, The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799. Biochem. Pharmacol. 34, 3939-3940 (1985).
51. M. W. Gross, U. Karbach, K. Groebe, A. J. Franko and W. Mueller-Klieser, Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int. J. Cancer 61, 567-573 (1995).
52. I. Kim, M. J. Lemmon and J. M. Brown, The influence of irradiation of the tumor bed on tumor hypoxia. Measurements by radiation response, oxygen electrodes, and nitroimidazole binding. Radiat. Res. 135, 411-417 (1993).
53. S. M. Evans, W. T. Jenkins, B. Joiner, E. M. Lord and C. J. Koch, 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors. Cancer Res. 56, 405-411 (1996).
54. M. B. Parliament, L. I. Wiebe and A. J. Franko, Nitroimidazole adducts as markers for tissue hypoxia: Mechanistic studies in aerobic normal tissues and tumour cells. Br. J. Cancer 66, 1103-1108 (1992).
55. S. Dische, D. Machin and D. Chassange, A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: An interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix. Radiother. Oncol. 26, 93-103 (1993).
56. J. C. Murray, V. Randhawa and J. Denekamp, The effects of melphalan and misonidazole on the vasculature of a murine sarcoma. Br. J. Cancer 55, 233-238 (1987).
57. D. J. Chaplin and M. R. Horsman, Tumor blood flow changes induced by chemical modifiers of radiation response. Int. J. Radiat. Oncol. Biol. Phys. 22, 459-462 (1992).
58. M. R. Horsman, D. W. Siemann, M. Nordsmark, A. A. Khalil, J. Overgaard and D. J. Chaplin, The combination of nicotinamide and carbogen breathing to improve tumor oxygenation prior to radiation treatment. In Oxygen Transport to Tissue (M. C. Hogan, O. Mathieu-Costello, D. C. Poole and P. D. Wagner, Eds.), pp. 635-642. Plenum Press, New York, 1994.
59. R. V. Fisker, M. R. Horsman and J. Overgaard, Hydralazine induced changes in tissue perfusion and radiation response in a C3H mammary carcinoma and mouse normal tissues. Acta Oncol. 30, 641-647 (1991).
60. M. J. Trotter, D. J. Chaplin, R. E. Durand and P. L. Olive, The use of fluorescent probes to identify regions of transient perfusion in murine tumors. Int. J. Radiat. Oncol. Biol. Phys. 16, 931-934 (1989).