Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells

Cancer Research

Volumn 62, Issue 7, 2002, Pages 2013-2018

  Harada, Hiroshi ^a   Hiraoka, Masahiro ^a   Kizaka Kondoh, Shinae ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CASPASE 3; HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CATALYSIS; CELL CULTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SOLID TUMOR; TREATMENT PLANNING;

3T3 CELLS; ADENOCARCINOMA; AMINO ACID SEQUENCE; ANIMALS; BETA-GALACTOSIDASE; CASPASE 3; CASPASES; CELL HYPOXIA; GENE PRODUCTS, TAT; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; OXYGEN; PANCREATIC NEOPLASMS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036531825     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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