-
1
-
-
0022469972
-
Acute hypoxia in tumour: Implications for modifiers of radiation effects
-
D.J. Chaplin, R.E. Durand, and P.L. Olive Acute hypoxia in tumour: implications for modifiers of radiation effects Int J Radiat Oncol Biol Phys 12 1986 1279 1282
-
(1986)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1279-1282
-
-
Chaplin, D.J.1
Durand, R.E.2
Olive, P.L.3
-
2
-
-
0023107539
-
Intermittent blood flow in a murine tumour: Radiobiological effects
-
D.J. Chaplin, P.L. Olive, and R.E. Durand Intermittent blood flow in a murine tumour: radiobiological effects Cancer Res 47 1987 597 601
-
(1987)
Cancer Res
, vol.47
, pp. 597-601
-
-
Chaplin, D.J.1
Olive, P.L.2
Durand, R.E.3
-
3
-
-
0025354544
-
Intermittent blood flow in the KHT sarcoma-flow cytometry studies using Hoechst 33342
-
A.I. Minchinton, R.E. Durand, and D.J. Chaplin Intermittent blood flow in the KHT sarcoma-flow cytometry studies using Hoechst 33342 Br J Cancer 62 1990 195 200
-
(1990)
Br J Cancer
, vol.62
, pp. 195-200
-
-
Minchinton, A.I.1
Durand, R.E.2
Chaplin, D.J.3
-
4
-
-
0032521248
-
Radiobiological hypoxia in the KHT sarcoma: Predictions using the Eppendorf histograph
-
D.W. Siemann, I.M. Johansen, and M.R. Horsman Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph Int J Radiat Oncol Biol Phys 40 1998 1171 1176
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.40
, pp. 1171-1176
-
-
Siemann, D.W.1
Johansen, I.M.2
Horsman, M.R.3
-
5
-
-
84960987950
-
The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
L.H. Gray, A.D. Conger, M. Ebert, S. Hornsey, and O.C. Scott The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy Br J Radiol 26 1953 638 648
-
(1953)
Br J Radiol
, vol.26
, pp. 638-648
-
-
Gray, L.H.1
Conger, A.D.2
Ebert, M.3
Hornsey, S.4
Scott, O.C.5
-
6
-
-
4644279732
-
Microregional effects of gemcitabine in HCT-116 xenografts
-
L.A. Huxham, A.H. Kyle, J.H. Baker, L.K. Nykilchuk, and A.I. Minchinton Microregional effects of gemcitabine in HCT-116 xenografts Cancer Res 64 2004 6537 6541
-
(2004)
Cancer Res
, vol.64
, pp. 6537-6541
-
-
Huxham, L.A.1
Kyle, A.H.2
Baker, J.H.3
Nykilchuk, L.K.4
Minchinton, A.I.5
-
7
-
-
0008461787
-
Delivery of molecular and cellular medicine to solid tumors
-
R.K. Jain Delivery of molecular and cellular medicine to solid tumors Microcirculation 4 1997 3 21
-
(1997)
Microcirculation
, vol.4
, pp. 3-21
-
-
Jain, R.K.1
-
8
-
-
0031747280
-
The next frontier of molecular medicine: Delivery of therapeutics
-
R.K. Jain The next frontier of molecular medicine: delivery of therapeutics Nat Med 4 1998 655 657
-
(1998)
Nat Med
, vol.4
, pp. 655-657
-
-
Jain, R.K.1
-
9
-
-
4344578280
-
Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture
-
A.H. Kyle, L.A. Huxham, A.S. Chiam, D.H. Sim, and A.I. Minchinton Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture Cancer Res 64 2004 6304 6309
-
(2004)
Cancer Res
, vol.64
, pp. 6304-6309
-
-
Kyle, A.H.1
Huxham, L.A.2
Chiam, A.S.3
Sim, D.H.4
Minchinton, A.I.5
-
10
-
-
0036307898
-
Limited penetration of anticancer drugs through tumor tissue: A potential cause of resistance of solid tumors to chemotherapy
-
I.F. Tannock, C.M. Lee, J.K. Tunggal, D.S. Cowan, and M.J. Egorin Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy Clin Cancer Res 8 2002 878 884
-
(2002)
Clin Cancer Res
, vol.8
, pp. 878-884
-
-
Tannock, I.F.1
Lee, C.M.2
Tunggal, J.K.3
Cowan, D.S.4
Egorin, M.J.5
-
11
-
-
0031716020
-
Oxygen predicts radiation response and survival in patients with cervix cancer
-
A.W. Fyles, M. Milosevic, and R. Wong Oxygen predicts radiation response and survival in patients with cervix cancer Radiother Oncol 48 1998 149 156
-
(1998)
Radiother Oncol
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
-
12
-
-
0027730121
-
Tumor oxygenation: A new predictive parameter in locally advanced cancer of the uterine cervix
-
M. Höckel, B. Vorndran, K. Schlenger, E. Baussmann, and P.G. Knapstein Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervix Gynecol Oncol 51 1993 141 149
-
(1993)
Gynecol Oncol
, vol.51
, pp. 141-149
-
-
Höckel, M.1
Vorndran, B.2
Schlenger, K.3
Baussmann, E.4
Knapstein, P.G.5
-
13
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
M. Höckel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 56 1996 4509 4515
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Höckel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
14
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
M. Nordsmark, M. Overgaard, and J. Overgaard Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck Radiother Oncol 41 1996 31 39
-
(1996)
Radiother Oncol
, vol.41
, pp. 31-39
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
15
-
-
26444466467
-
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
-
M. Nordsmark, S.M. Bentzen, and V. Rudat Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study Radiother Oncol 77 2005 18 24
-
(2005)
Radiother Oncol
, vol.77
, pp. 18-24
-
-
Nordsmark, M.1
Bentzen, S.M.2
Rudat, V.3
-
16
-
-
0036896722
-
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer
-
J.H. Kaanders, K.I. Wijffels, and H.A. Marres Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer Cancer Res 62 2002 7066 7074
-
(2002)
Cancer Res
, vol.62
, pp. 7066-7074
-
-
Kaanders, J.H.1
Wijffels, K.I.2
Marres, H.A.3
-
17
-
-
0035698467
-
Measuring hypoxia in solid tumours - Is there a gold standard?
-
P.L. Olive, J.P. Banath, and C. Aquino-Parsons Measuring hypoxia in solid tumours - is there a gold standard? Acta Oncol 40 2001 917 923
-
(2001)
Acta Oncol
, vol.40
, pp. 917-923
-
-
Olive, P.L.1
Banath, J.P.2
Aquino-Parsons, C.3
-
18
-
-
28444476902
-
Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
-
A. Yaromina, T. Holscher, and W. Eicheler Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma? Radiother Oncol 76 2005 206 212
-
(2005)
Radiother Oncol
, vol.76
, pp. 206-212
-
-
Yaromina, A.1
Holscher, T.2
Eicheler, W.3
-
19
-
-
3543137677
-
The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma
-
P.J. Hoskin, A. Sibtain, F.M. Daley, M.I. Saunders, and G.D. Wilson The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma Radiother Oncol 72 2004 159 168
-
(2004)
Radiother Oncol
, vol.72
, pp. 159-168
-
-
Hoskin, P.J.1
Sibtain, A.2
Daley, F.M.3
Saunders, M.I.4
Wilson, G.D.5
-
20
-
-
0842324834
-
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors
-
H.L. Janssen, F.J. Hoebers, and D. Sprong Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors Radiother Oncol 70 2004 91 97
-
(2004)
Radiother Oncol
, vol.70
, pp. 91-97
-
-
Janssen, H.L.1
Hoebers, F.J.2
Sprong, D.3
-
21
-
-
0038523737
-
Tumor hypoxia at the micro-regional level: Clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers
-
J. Bussink, J.H. Kaanders, and A.J. van der Kogel Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers Radiother Oncol 67 2003 3 15
-
(2003)
Radiother Oncol
, vol.67
, pp. 3-15
-
-
Bussink, J.1
Kaanders, J.H.2
Van Der Kogel, A.J.3
-
22
-
-
0037847453
-
Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
-
M. Nordsmark, J. Loncaster, and C. Aquino-Parsons Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas Radiother Oncol 67 2003 35 44
-
(2003)
Radiother Oncol
, vol.67
, pp. 35-44
-
-
Nordsmark, M.1
Loncaster, J.2
Aquino-Parsons, C.3
-
23
-
-
0037430244
-
GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
-
R.E. Airley, J. Loncaster, and J.A. Raleigh GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding Int J Cancer 104 2003 85 91
-
(2003)
Int J Cancer
, vol.104
, pp. 85-91
-
-
Airley, R.E.1
Loncaster, J.2
Raleigh, J.A.3
-
24
-
-
0035893551
-
Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer
-
P.L. Olive, C. Aquino-Parsons, and S.H. MacPhail Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer Cancer Res 61 2001 8924 8929
-
(2001)
Cancer Res
, vol.61
, pp. 8924-8929
-
-
Olive, P.L.1
Aquino-Parsons, C.2
MacPhail, S.H.3
-
25
-
-
84966192535
-
The histological structure of some human lung cancers and the possible implications for radiotherapy
-
R.H. Thomlinson, and L.H. Gray The histological structure of some human lung cancers and the possible implications for radiotherapy Br J Cancer 9 1955 539 549
-
(1955)
Br J Cancer
, vol.9
, pp. 539-549
-
-
Thomlinson, R.H.1
Gray, L.H.2
-
26
-
-
0018373569
-
Structure-activity relationships in the development of hypoxic cell radiosensitizers
-
G.E. Adams, E.D. Clarke, and I.R. Flockhart Structure-activity relationships in the development of hypoxic cell radiosensitizers Int J Radiat Biol 35 1978 133 150
-
(1978)
Int J Radiat Biol
, vol.35
, pp. 133-150
-
-
Adams, G.E.1
Clarke, E.D.2
Flockhart, I.R.3
-
27
-
-
0028632781
-
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
-
J. Overgaard Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors Oncol Res 6 1994 509 518
-
(1994)
Oncol Res
, vol.6
, pp. 509-518
-
-
Overgaard, J.1
-
28
-
-
0025968030
-
SR 4233 - A tumor specific radiosensitizer active in fractionated radiation regimes
-
J.M. Brown, and M.J. Lemmon SR 4233 - a tumor specific radiosensitizer active in fractionated radiation regimes Radiother Oncol 20 1991 151 156
-
(1991)
Radiother Oncol
, vol.20
, pp. 151-156
-
-
Brown, J.M.1
Lemmon, M.J.2
-
29
-
-
0023929181
-
Molecular mechanisms for the hypoxia dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)
-
K. Laderoute, P. Wardman, and A.M. Rauth Molecular mechanisms for the hypoxia dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) Biochem Pharmacol 37 1988 1487 1495
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 1487-1495
-
-
Laderoute, K.1
Wardman, P.2
Rauth, A.M.3
-
30
-
-
0026073332
-
SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures
-
K.A. Biedermann, J. Wang, R.P. Graham, and J.M. Brown SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures Br J Cancer 63 1991 358 362
-
(1991)
Br J Cancer
, vol.63
, pp. 358-362
-
-
Biedermann, K.A.1
Wang, J.2
Graham, R.P.3
Brown, J.M.4
-
31
-
-
0022493495
-
SR-4233: A bioreductive agent with high selective toxicity for hypoxic cells
-
E.M. Zeman, J.M. Brown, M.J. Lemmon, V.K. Hirst, and W.W. Lee SR-4233: a bioreductive agent with high selective toxicity for hypoxic cells Int J Radiat Biol Phys 12 1986 1239 1242
-
(1986)
Int J Radiat Biol Phys
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
32
-
-
0023750547
-
Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR-4233
-
E.M. Zeman, V.K. Hirst, M.J. Lemmon, and J.M. Brown Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR-4233 Radiother Oncol 12 1988 209 218
-
(1988)
Radiother Oncol
, vol.12
, pp. 209-218
-
-
Zeman, E.M.1
Hirst, V.K.2
Lemmon, M.J.3
Brown, J.M.4
-
33
-
-
0031023702
-
Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine
-
M.J. Dorie, and J.M. Brown Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine Cancer Chemother Pharmacol 39 1997 361 366
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 361-366
-
-
Dorie, M.J.1
Brown, J.M.2
-
34
-
-
0028079669
-
Comparison of the enhancement of tumor response to fractionated irradiation by SR 4233 (Tirapazamine) and by nicotinamide
-
M.J. Dorie, D. Menke, and J.M. Brown Comparison of the enhancement of tumor response to fractionated irradiation by SR 4233 (Tirapazamine) and by nicotinamide Int J Radiat Oncol Biol Phys 28 1993 145 150
-
(1993)
Int J Radiat Oncol Biol Phys
, vol.28
, pp. 145-150
-
-
Dorie, M.J.1
Menke, D.2
Brown, J.M.3
-
35
-
-
0031829934
-
Potentiation of cisplatin activity by the bioreductive agent tirapazamine
-
D.W. Siemann, and C.A. Hinchman Potentiation of cisplatin activity by the bioreductive agent tirapazamine Radiother Oncol 47 1998 215 220
-
(1998)
Radiother Oncol
, vol.47
, pp. 215-220
-
-
Siemann, D.W.1
Hinchman, C.A.2
-
36
-
-
84965808588
-
Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
-
M.J. Dorie, and J.M. Brown Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin Cancer Res 53 1993 4633 4636
-
(1993)
Cancer Res
, vol.53
, pp. 4633-4636
-
-
Dorie, M.J.1
Brown, J.M.2
-
37
-
-
0033063810
-
Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
-
M.S. Kovacs, D.J. Hocking, J.W. Evans, B.G. Siim, B.G. Wouters, and J.M. Brown Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin Br J Cancer 80 1999 1245 1251
-
(1999)
Br J Cancer
, vol.80
, pp. 1245-1251
-
-
Kovacs, M.S.1
Hocking, D.J.2
Evans, J.W.3
Siim, B.G.4
Wouters, B.G.5
Brown, J.M.6
-
38
-
-
0030669672
-
Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice
-
R.E. Durand, and P.L. Olive Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice Radiat Oncol Invest 5 1997 213 219
-
(1997)
Radiat Oncol Invest
, vol.5
, pp. 213-219
-
-
Durand, R.E.1
Olive, P.L.2
-
39
-
-
0031785201
-
Extravascular diffusion of tirapazamine: Effect of metabolic consumption assessed using the multicellular layer model
-
K.O. Hicks, Y. Fleming, B.G. Siim, C.J. Koch, and W.R. Wilson Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model Int J Radiat Oncol Biol Phys 42 1998 641 649
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 641-649
-
-
Hicks, K.O.1
Fleming, Y.2
Siim, B.G.3
Koch, C.J.4
Wilson, W.R.5
-
40
-
-
0032917763
-
Measurement of delivery and metabolism of tirapazamine through tumour tissue using the multilayered cell culture model
-
A. Kyle, and A.I. Minchinton Measurement of delivery and metabolism of tirapazamine through tumour tissue using the multilayered cell culture model Cancer Chemother Pharmacol 43 1999 213 220
-
(1999)
Cancer Chemother Pharmacol
, vol.43
, pp. 213-220
-
-
Kyle, A.1
Minchinton, A.I.2
-
41
-
-
0035847180
-
3-Amino-1,2,4-benzotriazine 4-oxide: Characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (Tirapazamine)
-
T. Fuchs, G. Chowdhury, C.L. Barnes, and K.S. Gates 3-Amino-1,2,4- benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (Tirapazamine) J Org Chem 66 2001 107 114
-
(2001)
J Org Chem
, vol.66
, pp. 107-114
-
-
Fuchs, T.1
Chowdhury, G.2
Barnes, C.L.3
Gates, K.S.4
-
42
-
-
0141731335
-
Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent
-
A.H. Kyle, L.A. Huxham, J.H. Baker, H.E. Burston, and A.I. Minchinton Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent Cancer Res 63 2003 5707 5711
-
(2003)
Cancer Res
, vol.63
, pp. 5707-5711
-
-
Kyle, A.H.1
Huxham, L.A.2
Baker, J.H.3
Burston, H.E.4
Minchinton, A.I.5
-
43
-
-
0141507967
-
Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures
-
K.O. Hicks, F.B. Pruijn, J.R. Sturman, W.A. Denny, and W.R. Wilson Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures Cancer Res 63 2003 5970 5977
-
(2003)
Cancer Res
, vol.63
, pp. 5970-5977
-
-
Hicks, K.O.1
Pruijn, F.B.2
Sturman, J.R.3
Denny, W.A.4
Wilson, W.R.5
-
44
-
-
0033000313
-
2 gradients in window chamber tumours: Impact on tumour hypoxia
-
2 gradients in window chamber tumours: impact on tumour hypoxia Br J Cancer 79 1999 1717 1722
-
(1999)
Br J Cancer
, vol.79
, pp. 1717-1722
-
-
Dewhirst, M.W.1
Ong, E.T.2
Braun, R.D.3
-
45
-
-
0023082510
-
Tumor hypoxia: Its impact on cancer therapy
-
J.E. Moulder, and S. Rockwell Tumor hypoxia: its impact on cancer therapy Cancer Metastases Rev 5 1987 313 341
-
(1987)
Cancer Metastases Rev
, vol.5
, pp. 313-341
-
-
Moulder, J.E.1
Rockwell, S.2
-
46
-
-
0028276699
-
Synergistic interaction between tirapazamine and cyclophosphamide in human breast cancer xenografts
-
V.K. Langmuir, J.A. Rooker, M. Osen, H.L. Mendonca, and K.R. Laderoute Synergistic interaction between tirapazamine and cyclophosphamide in human breast cancer xenografts Cancer Res 54 1994 2845 2847
-
(1994)
Cancer Res
, vol.54
, pp. 2845-2847
-
-
Langmuir, V.K.1
Rooker, J.A.2
Osen, M.3
Mendonca, H.L.4
Laderoute, K.R.5
-
47
-
-
0030951899
-
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
-
G.G. Dark, S.A. Hill, V.E. Prise, G.M. Tozer, G.R. Pettit, and D.J. Chaplin Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature Cancer Res 57 1997 1829 1834
-
(1997)
Cancer Res
, vol.57
, pp. 1829-1834
-
-
Dark, G.G.1
Hill, S.A.2
Prise, V.E.3
Tozer, G.M.4
Pettit, G.R.5
Chaplin, D.J.6
-
48
-
-
0036282385
-
The biology of the combretastatins as tumour vascular targeting agents
-
G.M. Tozer, C. Kanthou, C.S. Parkins, and S.A. Hill The biology of the combretastatins as tumour vascular targeting agents Int J Exp Pathol 83 2002 21 38
-
(2002)
Int J Exp Pathol
, vol.83
, pp. 21-38
-
-
Tozer, G.M.1
Kanthou, C.2
Parkins, C.S.3
Hill, S.A.4
|