Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: Evidence that HIF-2α has a role in NGF-promoted survival of sympathetic neurons

Molecular Pharmacology

Volumn 75, Issue 5, 2009, Pages 1198-1209

  Lomb, David J ^a,c   Desouza, Lynette A ^a   Franklin, James L ^b   Freeman, Robert S ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; DEOXYGLUCOSE; DIMETHYLOXALYLGLYCINE; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NERVE GROWTH FACTOR; PROLYLHYDROXYLASE INHIBITOR; PROTOCATECHUIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; EXTRACELLULAR SPACE; GENE DISRUPTION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SYMPATHETIC NERVE CELL;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL SURVIVAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME INHIBITORS; GLUCOSE; HYDROXYBENZOIC ACIDS; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SUPERIOR CERVICAL GANGLION;

EID: 66049129028     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053157     Document Type: Article

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